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Targets Recommended: Adenosine Receptor

43

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T37793	A2B receptor antagonist 2 A2B receptor antagonist 2	Adenosine Receptor	GPCR/G Protein; Neuroscience
	A2B receptor antagonist 2 是腺苷受体 A2B 的拮抗剂（rA1 的 Ki = 2.30 μM，rA2A 的 Ki = 6.8 μM，hA2B 的 3.44 μM）。
T10058	A2B receptor antagonist 1	Adenosine Receptor	GPCR/G Protein; Neuroscience
	A2B receptor antagonist 1 是一个有效的 A2B 腺苷受体 (A2B adenosine receptor) 拮抗剂。
T77508	A2B receptor antagonist 2 hydrochloride	Others	Others
	A2B receptor antagonist 2 hydrochloride 是腺苷受体 A2B 的拮抗剂（rA1 的 Ki = 2.30 μM，rA2A 的 Ki = 6.8 μM，hA2B 的 3.44 μM）
T21389	Enprofylline Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum,恩丙茶碱	Others	Others
	Enprofylline (Enprofilina) 是具有选择性的 A2B 受体竞争性拮抗剂 (Ki:7 μM) ，也是磷酸二酯酶抑制剂。它可用于研究哮喘、慢性阻塞性肺疾病。
T30696	Calonyctin A-2b DC-2b	Others	Others
	Calonyctin A-2b is one of two components of calonyctin A.
T23593	A2B57 A 2 B 57,A-2-B-57	Others	Others
	A2B57 is a selective SIRT2 inhibitor.
TMAZ-0236A	Anti-GUCA2B Monoclonal Antibody-APC
	Anti-GUCA2B Monoclonal Antibody-APC is a biotin-conjugated humanized rabbit antibody targeting GUCA2B. Anti-GUCA2B Monoclonal Antibody-APC can be used ELISA, FACS, IF.
TMAZ-0236A4	Anti-GUCA2B Monoclonal Antibody-AF488
	Anti-GUCA2B Monoclonal Antibody-AF488 is a biotin-conjugated humanized rabbit antibody targeting GUCA2B. Anti-GUCA2B Monoclonal Antibody-AF488 can be used ELISA, FACS, IF.
TMAZ-0236A5	Anti-GUCA2B Monoclonal Antibody-AF555
	Anti-GUCA2B Monoclonal Antibody-AF555 is a biotin-conjugated humanized rabbit antibody targeting GUCA2B. Anti-GUCA2B Monoclonal Antibody-AF555 can be used ELISA, FACS, IF.
TMAZ-0236A6	Anti-GUCA2B Monoclonal Antibody-AF647
	Anti-GUCA2B Monoclonal Antibody-AF647 is a biotin-conjugated humanized rabbit antibody targeting GUCA2B. Anti-GUCA2B Monoclonal Antibody-AF647 can be used ELISA, FACS, IF.
TMAZ-0236P	Anti-GUCA2B Monoclonal Antibody-PE
	Anti-GUCA2B Monoclonal Antibody-PE is a biotin-conjugated humanized rabbit antibody targeting GUCA2B. Anti-GUCA2B Monoclonal Antibody-PE can be used ELISA, FACS, IF.
TMAZ-0236B	Anti-GUCA2B Monoclonal Antibody-Biotin
	Anti-GUCA2B Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting GUCA2B. Anti-GUCA2B Monoclonal Antibody-Biotin can be used ELISA, FACS, IF.
T8512	BAY-545	Adenosine Receptor	GPCR/G Protein; Neuroscience
	BAY-545 是选择性的 A2B 腺苷受体抗剂，IC50值为 59 nM。在细胞中，它对人和大小鼠A2B 腺苷受体的IC50值分别为 66、280 和 400 nM，对人A2B 腺苷受体的Ki 值为 97 nM。
T27629	ISAM-140 ISAM140	Adenosine Receptor	GPCR/G Protein; Neuroscience
	ISAM-140 (22b) 是一种有效的、高选择性的 A2B adenosine receptor 拮抗剂，其 Ki 值为 3.49 nM。
T16140	MRS 1754	Adenosine Receptor	GPCR/G Protein; Neuroscience
	MRS 1754 是A2B 腺苷受体选择性拮抗剂，对人和大鼠的 A1和 A3受体的亲和力非常低。
T23203	PSB-603 PSB 603	Adenosine Receptor	GPCR/G Protein; Neuroscience
	PSB-603 是 Adenosine A2B receptor (Ki = 0.553 nM) 的选择性拮抗剂，具有抗炎作用。
T27800	LAS38096 LAS 38096,LAS-38096	Adenosine Receptor	GPCR/G Protein; Neuroscience
	LAS38096 是一种A2B 腺苷受体拮抗剂（Ki ：17 nM），具有强效性、选择性和高效性。
T16136	MRS-1706	Adenosine Receptor	GPCR/G Protein; Neuroscience
	MRS-1706 是一种选择性A2B 腺苷受体的反向激动剂，对人 A2B、A2A、A1和 A3受体的Ki 值分别为 1.39、112、157 和 230 nM。
T15418	GS-6201 CVT-6883	Adenosine Receptor	GPCR/G Protein; Neuroscience
	GS-6201 (CVT-6883) 是选择性腺苷 A2B 受体拮抗剂。它对人腺苷 A2B 受体具有高亲和力和选择性 (Ki=22 nM)。它降低了小鼠急性心肌梗死后心脏中 caspase-1 的活性，并减弱了心脏重塑。它减弱了致敏小鼠 NECA，AMP 或变应原诱导的气道反应性。
T9238	KI-7	Adenosine Receptor	GPCR/G Protein; Neuroscience
	KI-7 是一种A2B 腺苷受体阳性变构调节剂。它增强选择性 A2B 腺苷受体激动剂 BAY 60-6583 和腺苷诱导的 cAMP 积累，EC50分别为 2390 nM 和 2550 nM。它也增强非选择性 A2B 腺苷受体激动剂 NECA 诱导的 cAMP 积累，EC50为 445.8 nM。
T22234	Alloxazine	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Alloxazine 是一种 A2 受体拮抗剂，其对 A2B 受体的选择性比对 A2A 受体的选择性高约 10 倍。
T23201	PSB 1115	Adenosine Receptor	GPCR/G Protein; Neuroscience
	PSB 1115 是一种 A2B 受体拮抗剂，可以抵消 NECA 的抑制作用。
T14506	BAY 60-6583	Others; Adenosine Receptor	GPCR/G Protein; Neuroscience; Others
	BAY 60-6583 是一种强效、高亲和力的腺苷 A2B 受体激动剂（EC50 = 3 nM），对A2B 受体的亲和力超过对 A1、A2A 和 A3 受体的亲和力。BAY 60-6583 在心肌缺血模型中具有心脏保护作用。BAY 60-6583 与小鼠、兔子和狗 A2BAR 的结合 Ki 值分别为 750 nM、340 nM 和 330 nM。
T8613	1-Ethyl-6-aminouracil 6-AMINO-1-ETHYL-1H-PYRIMIDINE-2,4-DIONE,1-乙基-6-氨基脲嘧啶	Adenosine Receptor	GPCR/G Protein; Neuroscience
	1-Ethyl-6-aminouracil (6-AMINO-1-ETHYL-1H-PYRIMIDINE-2,4-DIONE) 是合成一系列新的取代黄嘌呤的中间体，这些黄嘌呤对人腺苷 A2B 受体具有高亲和力和选择性。
T14944	CGS 15943	PI3K; Adenosine Receptor	GPCR/G Protein; Neuroscience; PI3K/Akt/mTOR signaling
	CGS 15943 是一种可口服的非黄嘌呤腺苷受体拮抗剂。在转染的 CHO 细胞中，其对人 A1、A2A、A2B 和 A3 腺苷受体的 Ki 分别为 3.5、4.2、16 和 50 nM。
T6979	SCH 58261 SCH58261	Adenosine Receptor	GPCR/G Protein; Neuroscience
	SCH 58261 是一种强选择性的竞争性腺苷 A2A 受体拮抗剂，IC50值为 15 nM，对 A2A 受体的选择性分别是 A1、A2B 和 A3 受体的 323 倍、53 倍、100 倍。
T2671	Regadenoson CVT-3146,瑞加德松,Lexiscan	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Regadenoson (CVT-3146) 是一种腺苷衍生物和选择性 A2A 腺苷受体激动剂，具有冠状动脉舒张活性，对大鼠和猪腺苷 A2A 受体的Ki 分别为 290 和 1120 nM。它是血管扩张剂，可增加啮齿动物血脑屏障的通透性。
T23197	PSB 0788	Others	Others
	adenosine A2B receptor antagonist
T22937	LUF 5834	Others	Others
	A2A and A2B adenosine receptor partial agonist
T26681	ATL802 ATL 802,ATL-802	Others	Others
	ATL802 is an adenosine A2B Receptor antagonist.
T26680	ATL-801	Others	Others
	ATL-801 is anselective antagonist of A2B receptor with herapeutic activity for colitis.
T15715	LAS101057	Adenosine Receptor	GPCR/G Protein; Neuroscience
	LAS101057 是一种新型可口服且具有有效性和选择性的 A2B receptor 拮抗剂，可用于研究哮喘。
T26621	AMP-579 RPR100579,RPR 100579,AMP 579,RPR-100579	Others	Others
	AMP-579 is an adenosine A1 receptor agonist. AMP-579 also acts as a A2b-adenosine receptor agonist in human 293 cells and rabbit hearts.
T84741	PSB-1115 potassium salt	Others	Others
	PSB-1115 potassium salt是选择性A2B腺苷受体拮抗剂，能够抑制三硝基苯磺酸(TNBS)诱导的乙酰胆碱(ACh)收缩抑制现象。
T69675	PSB-1901 free base	Others	Others
	PSB-1901 is a potent A2B Adenosine Receptor Antagonist with Picomolar Potency (Ki 0.0835 nM, KB 0.0598 nM, human A2BAR) with >10 000-fold selectivity versus all other AR subtypes. PSB-1901 was similarly potent and selective at the mouse A2BAR, making it a promising tool for preclinical studies.
T70421	VCP746	Others	Others
	VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moiety linked to an adenosine A1 receptor (A1AR) allosteric modulator moiety. At the A1AR, VCP746 mediated cardioprotection in the absence of haemodynamic side effects such as bradycardia.
T62611	Adenosine receptor antagonist 2	Others	Others
	Adenosine receptor antagonist 2 是一种具有口服活性的 A2a (IC50: 1 nM) /A2b (IC50: 3 nM) 腺苷受体拮抗剂。Adenosine receptor antagonist 2 表现出抗肿瘤效果。
T61850	Adenosine receptor inhibitor 1	Others	Others
	Adenosine receptor inhibitor 1 is a highly potent and selective antagonist of adenosine receptor (AR). It exhibits exceptional affinity for A1 AR, A2A AR, A2B AR, and A3 AR, with respective Ki values of >1000, 68.5, >1000, >1000 nM. This compound demonstrates notable antinociceptive, anti-inflammatory, and peripheral analgesic properties. Therefore, Adenosine receptor inhibitor 1 holds great promise for investigating cancer and neurodegenerative diseases [1].
T63856	M1069	Others	Others
	M1069 是一种选择性的、口服具有活力的 A2A/A2B 型双腺苷受体拮抗剂，选择性比 A1、 A3亚型高 100 多倍。M1069 可拮抗腺苷引起的免疫抑制机制，表现出抗肿瘤作用。
T83958	CELT-327	Others	Others
	CELT-327是一种高效且选择性的荧光hA2B/A3腺苷受体拮抗剂，其Kivalues在A2B和A3受体上分别为35.6 nM和45.7 nM。在表达A2B腺苷受体的HCT116细胞中，CELT-327表现出剂量依赖性的膜荧光标记，荧光信号快速扩散并在细胞单层中均匀分布。在活的HCT116紧凑球体中，CELT-327展现出整个球体直径上的均匀染色，可达到球体深层区域。CELT-327可作为荧光腺苷受体探针用于荧光结合分析、活细胞成像、流式细胞术和荧光偏振分析。它是GPCR放射标记配体的合适替代品。激发和发射最大值（λ）分别为589 nm和616 nm。这些波长与作为TR-FRET分析中接受体染料使用兼容，与CoraFluor1 TR-FRET供体一同使用。
T62797	A2A receptor antagonist 3	Others	Others
	A2A receptor antagonist 3 (Example 92) 是一种 adenosine A2a receptor 拮抗剂 (Ki: 0.4 nM)。A2A receptor antagonist 3 也可以结合 A2b 受体 (Ki: 37 nM)、A1 受体 (Ki: 107 nM) 和 A3 受体 (Ki: 1467 nM)。
T37669	CAY10498	Others	Others
	The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. The four AR subtypes have been implicated in several areas of therapeutic interest such as stroke and other ischemic conditions, as well as inflammation, neurodegenerative diseases, diabetes, and sleep regulation. A3 AR antagonists are of interest as therapeutic agents in glaucoma agents and inflammation. CAY10498 is a potent and selective A3 AR antagonist exhibiting a Ki of 37 nM with 60 and 200-fold ...
T23202	PSB 36	Others	Others
	A1 adenosine receptor antagonist

化合物

A2B receptor antagonist 2

Cat.No: T37793

Synonym: A2B receptor antagonist 2

Target: Adenosine Receptor

A2B receptor antagonist 1

Cat.No: T10058

Target: Adenosine Receptor

A2B receptor antagonist 2 hydrochloride

Cat.No: T77508

Target: Others

Cat.No: T21389

Synonym: Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum,恩丙茶碱

Target: Others

Calonyctin A-2b

Cat.No: T30696

Synonym: DC-2b

Target: Others

Cat.No: T23593

Synonym: A 2 B 57,A-2-B-57

Target: Others

Anti-GUCA2B Monoclonal Antibody-APC

Cat.No: TMAZ-0236A

Anti-GUCA2B Monoclonal Antibody-AF488

Cat.No: TMAZ-0236A4

Anti-GUCA2B Monoclonal Antibody-AF555

Cat.No: TMAZ-0236A5

Anti-GUCA2B Monoclonal Antibody-AF647

Cat.No: TMAZ-0236A6

Anti-GUCA2B Monoclonal Antibody-PE

Cat.No: TMAZ-0236P

Anti-GUCA2B Monoclonal Antibody-Biotin

Cat.No: TMAZ-0236B

Cat.No: T8512

Target: Adenosine Receptor

Cat.No: T27629

Synonym: ISAM140

Target: Adenosine Receptor

Cat.No: T16140

Target: Adenosine Receptor

Cat.No: T23203

Synonym: PSB 603

Target: Adenosine Receptor

Cat.No: T27800

Synonym: LAS 38096,LAS-38096

Target: Adenosine Receptor

Cat.No: T16136

Target: Adenosine Receptor

Cat.No: T15418

Synonym: CVT-6883

Target: Adenosine Receptor

Cat.No: T9238

Target: Adenosine Receptor

Cat.No: T22234

Target: Adenosine Receptor

Cat.No: T23201

Target: Adenosine Receptor

Cat.No: T14506

Target: Others, Adenosine Receptor

1-Ethyl-6-aminouracil

Cat.No: T8613

Synonym: 6-AMINO-1-ETHYL-1H-PYRIMIDINE-2,4-DIONE,1-乙基-6-氨基脲嘧啶

Target: Adenosine Receptor

Cat.No: T14944

Target: PI3K, Adenosine Receptor

Cat.No: T6979

Synonym: SCH58261

Target: Adenosine Receptor

Cat.No: T2671

Synonym: CVT-3146,瑞加德松,Lexiscan

Target: Adenosine Receptor

Cat.No: T23197

Target: Others

Cat.No: T22937

Target: Others

Cat.No: T26681

Synonym: ATL 802,ATL-802

Target: Others

Cat.No: T26680

Target: Others

Cat.No: T15715

Target: Adenosine Receptor

Cat.No: T26621

Synonym: RPR100579,RPR 100579,AMP 579,RPR-100579

Target: Others

PSB-1115 potassium salt

Cat.No: T84741

Target: Others

PSB-1901 free base

Cat.No: T69675

Target: Others

Cat.No: T70421

Target: Others

Adenosine receptor antagonist 2

Cat.No: T62611

Target: Others

Adenosine receptor inhibitor 1

Cat.No: T61850

Target: Others

Cat.No: T63856

Target: Others

Cat.No: T83958

Target: Others

A2A receptor antagonist 3

Cat.No: T62797

Target: Others

Cat.No: T37669

Target: Others

Cat.No: T23202

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01465	HNRNPA2B1 Protein, Human, Recombinant (His & Myc) HNRNPA2B1,Heterogeneous nuclear ribonucleoproteins ...	Human	E. coli
	HNRNPA2B1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-02705	HNRNPA2B1 Protein, Mouse, Recombinant (His & Myc & SUMO) Hnrnpa2b1,Heterogeneous nuclear ribonucleoproteins ...	Mouse	E. coli
	HNRNPA2B1 Protein, Mouse, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPH-02228	TRA2B Protein, Human, Recombinant (His & Myc) TRA2B,Transformer-2 protein homolog B,Splicing fact...	Human	Baculovirus Insect Cells
	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
TMPH-01424	GUCA2B Protein, Human, Recombinant (His) Guanylate cyclase activator 2B,GUCA2B	Human	HEK293 Cells
	Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. GUCA2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 13.5 kDa and the accession number is Q16661.
TMPH-00271	HNRNPA2B1 Protein, Bovine, Recombinant (His & SUMO) Heterogeneous nuclear ribonucleoproteins A2/B1,HNRNPA2B<...	Bovine	E. coli
	HNRNPA2B1 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.0 kDa and the accession number is Q2HJ60.
TMPY-06353	GUCA2B Protein, Mouse, Recombinant (His) Ugn,AV066530,Gcap2,guanylate cyclase activator 2B (uroguanyl...	Mouse	HEK293 Cells
	GUCA2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.55 kDa and the accession number is Q3UWA6-1.
TMPH-01095	CELA2B Protein, Human, Recombinant (His & SUMO) Chymotrypsin-like elastase family member 2B,ELA2B,E...	Human	E. coli
	Acts upon elastin. CELA2B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 38.8 kDa and the accession number is P08218.
TMPH-02229	TRA2B Protein, Human, Recombinant (His & SUMO) TRA2B,Transformer-2 protein homolog B,Splicing fact...	Human	E. coli
	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. TRA2B Protein, Human, Recombinant (His & SUMO) is expr...
TMPK-00861	A2AR Protein-VLP, Human, Recombinant RDC8,Adenosine A2a R,ADORA2,ADORA 2,ADORA2A,A2aR	Human	HEK293 Cells
	Adenosine is a neuromodulator in the adult central nervous system. Membrane-bound receptors for adenosine have been identified and cDNAs for A1, A2a, A2b, and A3 adenosine receptor subtypes have been cloned recently.Expression of A2a adenosine receptor mRNA in cranial ganglia, carotid body, and intermediate lobe of the pituitary gland similarly suggests novel sites of adenosine action during development and in the adult.

重组蛋白

HNRNPA2B1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01465

Species: Human

Expression System: E. coli

HNRNPA2B1 Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02705

Species: Mouse

Expression System: E. coli

TRA2B Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02228

Species: Human

Expression System: Baculovirus Insect Cells

GUCA2B Protein, Human, Recombinant (His)

Cat.No: TMPH-01424

Species: Human

Expression System: HEK293 Cells

HNRNPA2B1 Protein, Bovine, Recombinant (His & SUMO)

Cat.No: TMPH-00271

Species: Bovine

Expression System: E. coli

GUCA2B Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06353

Species: Mouse

Expression System: HEK293 Cells

CELA2B Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01095

Species: Human

Expression System: E. coli

TRA2B Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02229

Species: Human

Expression System: E. coli

A2AR Protein-VLP, Human, Recombinant

Cat.No: TMPK-00861

Species: Human

Expression System: HEK293 Cells

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