37
1
165
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T68730 |
AVE1231
|
Potassium Channel | Membrane transporter/Ion channel |
AVE1231 是一种 TASK-1 通道阻滞剂,抑制 TASK-1 ,可用于研究心房颤动。 | |||
T3348 |
PIK-293
PIK293 |
PI3K | PI3K/Akt/mTOR signaling |
PIK-293 是一种 IC87114 的类似物,是一种 PI3K 的抑制剂,其对 p110δ (IC50:0.24 μM)、p110β (IC50:10 μM)、p110γ (IC50:25 μM) 和 p110α (IC50:100 μM)。 | |||
T5418 |
BAY-293
|
Raf; Ras | GPCR/G Protein; MAPK |
BAY-293 是化学探针,是一种有效的细胞活性 SOS1 抑制剂,可破坏 KRAS-SOS1 相互作用,IC50为 21 nM。 | |||
T69857 |
DB293
|
Others | Others |
DB293 is an inhibitor of PIT-1 and BRN-3 transcription factors. DB293 binds as head-to-tail stacked dimers in the minor groove of 5'-ATGA sequence, thereby leading to an increase in the size of minor groove. | |||
T41214 |
(S)-BAY-293
BAY 294,BAY 293 Negative Control |
Ras | GPCR/G Protein; MAPK |
(S)-BAY-293 是一种有效的 pan-KRAS 抑制剂,可用于研究原发性非小肺癌和胰腺癌。 | |||
T83393 |
293P-1
|
||
293P-1是一种特异性靶向肝细胞的组织特异性多肽,其序列为SNNNVRPIHIWP。 | |||
T19700 |
IBC 293
IBC293,1-异丙基-1H-1,2,3-苯并噻唑-5-羧酸,IBC-293 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
IBC 293 对 GPR109B 的选择性高于烟酸受体 GPR109A。 IBC 293 是 GPR109B 的高选择性激动剂,GPR109B 是一种在脂肪细胞中表达的人类孤儿 G 蛋白偶联受体。 | |||
T9019 |
JHU37152
JHU 37152 |
AChR | Neuroscience |
JHU37152 (JHU 37152) 是一种可透过血脑屏障的DREADD 激动剂。 在 HEK-293 细胞的荧光和基于 BRET 的测定中,对hM3Dq 和hM4Di DREADDs 的EC50值分别为 5 和 0.5 nM。 | |||
T16569 |
Praliciguat
IW-1973 |
Others; Guanylate cyclase | GPCR/G Protein; Others |
Praliciguat (IW-1973) 是一种有效且具有口服活性的可溶性鸟苷酸环化酶 (sGC) 刺激剂,还增强 NO 信号传导,可作为血管扩张剂。在 HEK-293 细胞中,它能够刺激 sGC,EC50值为 197 nM。 | |||
T6934 |
Pexmetinib
ARRY-614 |
Tie-2; p38 MAPK; Autophagy | Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Pexmetinib (ARRY-614) 是一种口服生物可利用的双重 p38 MAPK/Tie-2 抑制剂,可研究急性骨髓性白血病。在 HEK-293 细胞系中的 IC50 为 4 nM/18 nM。 | |||
T11076 |
Dooku1
|
Others | Others |
Dooku1 是Yoda1 的类似物,是一种内源性Piezo1通道的选择性拮抗剂,能够抑制Yoda1 诱导的主动脉舒张。它在HEK 293 细胞以及HUVEC 中测得对2 μM Yoda1 诱导的钙离子流的IC50值分别为1.3 μM 和1.5 μM。 | |||
T9018 |
JHU37160
JHU 37160 |
AChR | Neuroscience |
JHU37160 (JHU 37160) 是一种可透过血脑屏障的 DREADD 激动剂。在 HEK-293 细胞的荧光和基于 BRET 的测定中,对hM3Dq 和hM4Di DREADDs 的EC50值分别为 18.5 和 0.2 nM。 | |||
T2092 |
Amitifadine hydrochloride
DOV-21947 hydrochloride,EB-1010 hydrochloride |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
Amitifadine hydrochloride (EB-1010 hydrochloride) 是一种 5-羟色胺-去甲肾上腺素-多巴胺的再摄取抑制剂(SNDRI),其在 HEK 293 细胞中测得的 IC50值分别为 12, 23, 96 nM。 | |||
T4967 |
NPS-2143 hydrochloride
2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐,NPS-2143 HCL |
CaSR | GPCR/G Protein |
NPS-2143 hydrochloride (NPS-2143 HCL) 是一种口服具有活性的溶钙剂,是钙敏感受体(CaSR)的选择性拮抗剂。它能够激活表达人 Ca2+受体的 HEK 293 细胞中的 Ca2+受体,从而增加胞浆 Ca2+浓度(IC50=43 nM)。 | |||
T1730 |
NPS-2143
SB262470,NPS 2143,SB 262470A,2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈 |
Calcium Channel; CaSR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
NPS-2143 (SB 262470A) 是口服活性溶钙剂, 是选择性钙敏感受体拮抗剂。它通过激活表达人 Ca2+受体的 HEK 293 细胞中的 Ca2+受体而引起的胞浆 Ca2+浓度增加,IC50值为43 nM。 | |||
T5345 |
V-9302
|
Others | Others |
V-9302 是一种跨膜谷氨酰胺通量的竞争性拮抗剂。它选择性的靶向氨基酸转运体 ASCT2 (SLC1A5),不影响 ASCT1。它能够阻碍 HEK-293 细胞中由 ASCT2 介导的谷氨酰胺摄取 (IC50=9.6 μM)。 | |||
T15404 | GNE-6468 | Others | Others |
GNE-6468 is a potent and selective agonist of RORγ(RORc) (EC50: 13 nM for HEK-293 cell). | |||
T15398 |
GNE-0946
|
Others | Others |
GNE-0946 is a potent and selective agonist of RORγ (EC50: 4 nM for HEK-293 cell). | |||
T74577 |
Milpocitide
|
Others | Others |
Milpocitide为针对低密度脂蛋白受体(human LDL receptor, LDLR)(293-333)的肽片段(EGF-like domain 1)的化合物。 | |||
T27422 |
GNE-293
GNE293 |
Others | Others |
GNE-293 is a potent and selective PI3Kδ inhibitor. | |||
T81137 |
SNX7886
|
PROTACs | PROTAC |
SNX7886为高效CDK8/19蛋白降解剂,在293细胞中可分别降解CDK8与CDK19至90%及80%。 | |||
T26621 |
AMP-579
RPR100579,RPR 100579,AMP 579,RPR-100579 |
Others | Others |
AMP-579 is an adenosine A1 receptor agonist. AMP-579 also acts as a A2b-adenosine receptor agonist in human 293 cells and rabbit hearts. | |||
T10271 |
AHR antagonist 4
|
Others | Others |
AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects. | |||
T14190 |
Alniditan
Alnitidan |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively. | |||
T25109 |
ARN-6039
ARN 6039,ARN6039 |
Others | Others |
ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HEK 293 cells (360 nM) and in IL-17 r | |||
T38984 |
Z-Ala-Ala-Asn-AMC
Cbz-Ala-Ala-Asn-AMC,Z-Ala-Ala-Asn-AMC |
||
Z-Ala-Ala-Asn-AMC, also known as Cbz-Ala-Ala-Asn-AMC, serves as a substrate for legumain. The overexpression of legumain in 293 HEK-Leg cells results in efficient cleavage of Cbz-Ala-Ala-Asn-AMC. | |||
T63456 |
Antimalarial agent 12
|
Others | Others |
Antimalarial agent 12 是有效的抗疟 (antimalarial) 药,能够抑制恶性疟原虫 Dd2 菌株、3D7 菌株生长,其 EC50值分别为155 nM、136 nM。Antimalarial agent 12 对大肠杆菌的 MIC>250,000 nM,也能够作用于 HEK-293 和 hPHep 细胞系,其 CC50值为 10,000-50,000 nM。 | |||
T63608 |
P-gp inhibitor 5
|
Others | Others |
P-gp inhibitor 5 是 P 糖蛋白 (P-gp) 的有效抑制剂,在 1.25 μM 和 2.5 μM 时 P-gp 抑制倍数分别为 2.5 和 3.0。P-gp inhibitor 5 对某些癌细胞表现出抗增殖效果。P-gp inhibitor 5 能够恢复细胞对 Vincristine 和 Paclitaxel 的敏感性,进而逆转 ABCB1/Flp-InTM-293 和 KBvin 的多药耐药 (MDR) 表型。 | |||
T40064 |
V-9302 hydrochloride
|
Others | Others |
V-9302 hydrochloride is a potent and selective competitive antagonist that inhibits transmembrane glutamine flux by specifically targeting the amino acid transporter ASCT2 (SLC1A5), and not ASCT1. In HEK-293 cells, V-9302 hydrochloride effectively inhibits ASCT2-mediated glutamine uptake with an IC50 value of 9.6 μM. | |||
T74917 |
KPC-2-IN-1
|
Others | Others |
KPC-2-IN-1,硼酸衍生物,是一种有效的 KPC-2抑制剂,其 Ki 值为 0.032 μM。KPC-2-IN-1 能增强 cefotaxime 在表达 KPC-2的大肠杆菌中的活性。KPC-2-IN-1 对人类 HEK-293 细胞显示良好的耐受性,可用于大肠杆菌耐β-lactam 类抗生素的研究。 | |||
T77154 | Etrolizumab | ||
Etrolizumab (rhuMAb Beta7) 是一种肠道选择性抗-β7整合素单克隆抗体。Etrolizuma b 是针对α4β7和 αEβ7 整合素的 β7 亚基的特异性靶向活性分子。Etrolizumab 可用于炎症性肠病 (IBD) 的研究。 | |||
T61688 |
Nrf2 activator-2
|
Others | Others |
Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 activator-2 activates the Nrf2 pathway. Furthermore, this compound significantly reduces the ubiquitination of Nrf2 in cells, indicating its potential in regulating Nrf2 activity [1]. | |||
T37800 |
PF-04449613
|
Others | Others |
PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-0444... | |||
T75785 |
Apelin-17(human, bovine) TFA
|
||
Apelin-17(human, bovine) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂。Apelin-17(human, bovine) TFA 与在 HEK 293 细胞中表达的人 APJ 受体结合 (pIC50)。Apelin-17(human, bovine) TFA 阻断 HIV-1和 HIV-2毒株进入表达 APJ 的 NP-2/CD4 细胞。 | |||
T75783 |
Apelin-36(human) TFA
|
||
Apelin-36(human) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂,EC50为 20 nM。Apelin-36(human) TFA 对 HEK 293 细胞表达的人 APJ 受体有很高的亲和力 (pIC50=8.61)。Apelin-36(human) TFA 与两种主要的生物活性有关:心血管和代谢。Apelin-36(human) TFA 抑制 HIV-1和 HIV-2进入表达 APJ 的 NP2/CD4细胞。 | |||
T35836 |
PMX-205 (trifluoroacetate salt)
|
Others | Others |
PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela... | |||
T38174 |
Mpro inhibitor N3 hemihydrate
|
Others | Others |
Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC50 of 4.0 μM, 8.8 μM, and 2.7 μM, respectively[1][2]. Mpro inhibitor N3 hemihydrate (0-0.64 μM) is able to penetrate cells to inhibit the replication of IBV viruses... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T72508 |
Palmatine hydroxide
|
Others | Others |
Palmatine hydroxide 是不可逆的口服活性IDO-1抑制剂,其对HEK 293-hIDO-1 和 rhIDO-1的IC50值分别为3 μM和157 μM。该化合物还能非竞争性抑制(WNV)NS2B-NS3蛋白酶,IC50值为96 μM。Palmatine hydroxide展现了抗癌、抗炎、神经保护、抗细菌和抗病毒的活性。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02792 |
GDNF Protein, Human, Recombinant (HEK293)
HSCR3,ATF2,HFB1-GDNF,ATF1,glial c... |
Human | HEK293 Cells |
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2. | |||
TMPY-06985 |
NGF Protein, Human, Recombinant (HEK293)
NGFB,神经生长因子,Beta-NGF,HSAN5,β-NGF,nerve gro... |
Human | HEK293 Cells |
NGF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.8 kDa. and the accession number is P01138. | |||
TMPY-01920 |
BAFF/TNFSF13B Protein, Human, Recombinant (HEK293)
BAFF,THANK,BLYS,TNFSF20,CD257,tumor necros... |
Human | HEK293 Cells |
BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9Y275-1. | |||
TMPY-01191 |
CD3 epsilon/CD3e Protein, Human, Recombinant (HEK293, His)
IMD18,CD3 epsilon,T3E,CD3 ε,CD3e molecule, ε (CD3-TCR comple... |
Human | HEK293 Cells |
CD3 epsilon/CD3e Protein, Human, Recombinant (HEK293,His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.2 kDa and the accession number is P07766. | |||
TMPY-04090 |
Influenza A H7N9 (A/Shanghai/2/2013) Hemagglutinin/HA Protein (HEK293, His)
Harvey rat sarcoma vir |
H7N9 | HEK293 Cells |
Influenza A H7N9 (A/Shanghai/2/2013) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa. | |||
TMPY-01501 |
Influenza A H1N1 (A/Puerto Rico/8/1934) Hemagglutinin/HA Protein (HEK293, His)
Harvey rat sarcoma vir |
H1N1 | HEK293 Cells |
Influenza A H1N1 (A/Puerto Rico/8/1934) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is P03452. | |||
TMPJ-00895 |
SCF Protein, Rat, Recombinant (HEK293, His)
steel factor,Mast cell growth fac... |
Rat | HEK293 Cells |
SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II... | |||
TMPY-02024 |
L-selectin Protein, Human, Recombinant (HEK293,His)
LECAM1,TQ1,CD62L,LYAM1,LSEL,LNHR,LA |
Human | HEK293 Cells |
L-selectin Protein, Human, Recombinant (HEK293,His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.5 kDa and the accession number is P14151-1. | |||
TMPH-00343 |
Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His)
Angiopoietin-1,ANG-1,ANGPT1 |
Canine | HEK293 Cells |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His) is expressed in HEK293 mammalian cells wi... | |||
TMPY-06314 |
MMP-10 Protein, Human, Recombinant (HEK293, His)
STMY2,matrix metallopeptidase 10,... |
Human | HEK293 Cells |
MMP-10 Protein, Human, Recombinant (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.38 kDa and the accession number is P09238. | |||
TMPH-01683 |
Tau-F Protein, Human, Recombinant (HEK293, His)
Microtubule-associated protein ta... |
Human | HEK293 Cells |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the ... | |||
TMPJ-01022 |
SUMO3 Protein, Human, Recombinant (HEK293, His)
SMT3 homolog 1,Smt3A,Small ubiquitin-rel |
Human | HEK293 Cells |
Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way to alter their function, location, and/or half-life. Small ubiquitin-like modifiers include SUMO1, SUMO2, SUMO3, and SUMO4. Except for SUMO4, all other SUMOs are ubiquitously expressed, including in the brain. In human, SUMO2 and SUMO3 are two highly homologous proteins, collect... | |||
TMPY-02167 |
Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293)
DF,Adn,complement factor D (adips... |
Mouse | HEK293 Cells |
Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession number is P03953-2. | |||
TMPH-00743 |
PhoP Protein, E. coli, Recombinant (HEK293, His & Myc)
Transcriptional regulatory protei... |
E. coli | HEK293 Cells |
Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Mediates magnesium influx to the cytosol by activation o... | |||
TMPJ-01163 |
CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)
CTGF,Connective tissue growth factor |
Human | HEK293 Cells |
Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF has various biological functions, including cell adhesion, migration, proliferation, differentiation, and ECM production, and participates in the development of many organs under normal physio... | |||
TMPJ-00716 |
Cerberus 1/CER1 Protein, Human, Recombinant (HEK293, His)
DAN Domain Family Member 4,Cerber... |
Human | HEK293 Cells |
Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in respon... | |||
TMPJ-00386 |
ACE2/ACEH Protein, Human, Recombinant (HEK293, His & Avi), Biotinylated
Metalloprotease MPROT15,ACEH,... |
Human | HEK293 Cells |
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate... | |||
TMPY-05683 |
SARS-CoV-2 Spike RBD Protein (HEK293, His), Biotinylated
|
SARS-CoV-2 | HEK293 Cells |
SARS-CoV-2 Spike RBD Protein (HEK293, His), Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.54 kDa and the accession number is A0A6G7K2L4. | |||
TMPY-05719 |
SARS-CoV-2 Spike RBD Protein (HEK293, Avi & His), Biotinylated
|
SARS-CoV-2 | HEK293 Cells |
SARS-CoV-2 Spike RBD Protein (HEK293, Avi & His), Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 28.36 kDa and the accession number is A0A6G7K2L4. | |||
TMPY-05661 |
SARS-CoV-2 Spike S1 Protein (HEK293, His)
|
HEK293 Cells | |
SARS-CoV-2 Spike S1 Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The accession number is A0A6G7K2L4. | |||
TMPY-03800 |
Influenza A H7N9 (A/Shanghai/1/2013) Hemagglutinin/HA Protein (HEK293, His)
Harvey rat sarcoma vir |
H7N9 | HEK293 Cells |
Influenza A H7N9 (A/Shanghai/1/2013) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa. | |||
TMPY-05932 |
Influenza A H1N1 (A/swine/Canada/01093/2006) Neuraminidase/NA Protein (HEK293, His)
NA Protein |
H1N1 | HEK293 Cells |
Influenza A H1N1 (A/swine/Canada/01093/2006) Neuraminidase/NA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.2 kDa and the accession number is A0A0G3XQY1. | |||
TMPY-03840 |
Influenza A H7N9 (A/Pigeon/Shanghai/S1069/2013) Hemagglutinin/HA Protein (HEK293, His)
Harvey rat sarcoma vir |
H7N9 | HEK293 Cells |
Influenza A H7N9 (A/Pigeon/Shanghai/S1069/2013) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa. | |||
TMPY-00549 |
Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA Protein (HEK293, His)
Harvey rat sarcoma vir |
H5N1 | HEK293 Cells |
Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is B7NWR4. | |||
TMPY-00595 |
Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA1 Protein (HEK293, His)
Harvey rat sarcoma vir |
H5N1 | HEK293 Cells |
Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA1 Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is B7NWR4. | |||
TMPK-01419 |
Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
MHC,HLA-A*02:01,Peptide Ready |
Human | HEK293 Cells |
Peptide Ready HLA-A*03:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*03:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01426 |
Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi)
HLA-A*02:01,Peptide Ready,MHC |
Human | HEK293 Cells |
Peptide Ready HLA-A*11:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*11:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01421 |
Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
HLA-A*02:01,MHC,Peptide Ready |
Human | HEK293 Cells |
HLA-A*02:01&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01420 |
Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi)
Peptide Ready,MHC,HLA-A*02:01 |
Human | HEK293 Cells |
Peptide Ready HLA-A*03:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*03:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01410 |
Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi)
HLA-A,MHC,Peptide Ready |
Human | HEK293 Cells |
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01422 |
Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi)
Peptide Ready,MHC,HLA-A*02:01 |
Human | HEK293 Cells |
Peptide Ready HLA-A*02:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01425 |
Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
MHC,HLA-A*02:01,Peptide Ready |
Human | HEK293 Cells |
Peptide Ready HLA-A*11:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*11:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01415 |
APC-equivalent Peptide Ready HLA-A*02:01&B2M Tetramer Protein, Human, MHC (His)
Peptide Ready,HLA-A*02:01,MHC |
Human | HEK293 Cells |
Peptide Ready HLA-A*02:01&B2M Tetramer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01409 |
Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
Peptide Ready,MHC,HLA-A |
Human | HEK293 Cells |
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01510 |
HLA-A*03:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer Protein, Human, MHC (His & Avi)
NS,NS3,KRAS2,RASK2,MHC,RALD,K-R |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. | |||
TMPK-01463 |
HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Monomer Protein, Human, MHC (His & Avi)
C-K-RAS,KI-RAS,KRAS1,K-RA |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01429 |
HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated
MHC,K-Ras 2,NS,K-RAS4A,KRA |
Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01500 |
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi)
CTAG1,CT6.1,CTAG1B,LAGE2A |
Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. | |||
TMPK-01473 |
HLA-A*24:02&B2M&MAGE-A3 (IMPKAGLLI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
CT1.3,MAGE-3,MZ2-D,MZ2D,HLA-A2402... |
Human | HEK293 Cells |
Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine immunotherapy in patients with PCa. | |||
TMPK-01518 |
HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi)
MHC,NS,KRAS1,K-RAS2A,GTPa |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01527 |
HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (His & Avi)
NS,RALD,C-K-RAS,RASK2,K-RA |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01408 |
HLA-A*02:01&B2M&KRAS G12V (KLVVVGAVGV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
RALD,KRAS1,KRAS2,K-RAS2B... |
Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01433 |
HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Tetramer Protein, Human, MHC (His & Avi)
GTPase Kras,NS3,K-Ras 2,K-RA<... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01455 |
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi)
OIP4,PRAME,OIP-4,MAPE |
Human | HEK293 Cells |
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. | |||
TMPK-01401 |
HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi)
MHC,CFC2,K-Ras 2,RALD,K-RAS4A... |
Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. | |||
TMPK-01488 |
HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Monomer Protein, Human, MHC (His & Avi)
K-RAS4A,MHC,GTPase Kras,... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. | |||
TMPK-01442 |
HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
HLA-A,P53,TP53,LFS1,MHC,BCC7,TRP53,FLJ9294... |
Human | HEK293 Cells |
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth. | |||
TMPK-01445 |
HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
CT1.1,MAGE1,MAGE-1,MAGE-A |
Human | HEK293 Cells |
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. | |||
TMPK-01493 |
HLA-A*01:01&B2M&MAGE-A3 (EVDPIGHLY) Tetramer Protein, Human, MHC (His & Avi)
MZ2-D,Melanoma-associate... |
Human | HEK293 Cells |
Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine immunotherapy in patients with PCa. | |||
TMPK-01477 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
HPAFP,FETA,Alpha-1-fetop... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
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