702
125
6
6
296
44
Cat. No. | Product Name | ||
---|---|---|---|
L4150 | 新颖已知活性精选库 | 989 compounds | |
989 种百里挑一的活性化合物; | |||
L5100 | 含氟化合物库 | 574 compounds | |
574 个含氟化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L1510 | 核受体化合物库 | 531 compounds | |
531 个核受体作用化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2620 | 神经退行性疾病化合物库 | 2154 compounds | |
2154 种与神经退行性疾病相关的化合物,可用于高通量和高内涵筛选; | |||
L6130 | 萜类天然产物库 | 622 compounds | |
622 种萜类天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6120 | 黄酮类天然产物库 | 514 compounds | |
514 种黄酮类天然产物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0090 |
Mag Beads Streptavidin (1 μm)
链霉亲和素磁珠 (1 μm) |
Suspension in bottle | 免疫检测、分离蛋白;分离核酸、制备核酸探针;DN<em>A</em>-蛋白质相互作用研究;细胞分选与激活 |
C0092 |
Mag Beads Streptavidin (2.8 μm)
链霉亲和素磁珠 (2.8 μm) |
Suspension in bottle | 免疫检测、分离蛋白;分离核酸、制备核酸探针;DN<em>A</em>-蛋白质相互作用研究;细胞分选与激活 |
C0089 |
Mag Beads Streptavidin (300 nm)
链霉亲和素磁珠 (300 nm) |
Suspension in bottle | 免疫检测、分离蛋白;分离核酸、制备核酸探针;DN<em>A</em>-蛋白质相互作用研究;细胞分选与激活 |
C0093 |
Mag Beads Streptavidin (3 μm)
链霉亲和素磁珠 (3 μm) |
Suspension in bottle | 免疫检测、分离蛋白;分离核酸、制备核酸探针;DN<em>A</em>-蛋白质相互作用研究;细胞分选与激活 |
C0094 |
Mag Beads Streptavidin (5 μm)
链霉亲和素磁珠 (5 μm) |
Suspension in bottle | 免疫检测、分离蛋白;分离核酸、制备核酸探针;DN<em>A</em>-蛋白质相互作用研究;细胞分选与激活 |
C0091 |
Mag Beads Streptavidin (2 μm)
链霉亲和素磁珠 (2 μm) |
Suspension in bottle | 免疫检测、分离蛋白;分离核酸、制备核酸探针;DN<em>A</em>-蛋白质相互作用研究;细胞分选与激活 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36209 |
15-keto Prostaglandin A1
15-keto Prostaglandin A1 |
Others | Others |
Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase. It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations. 15-keto PGA1, given at a concentration of 6 μM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II. | |||
T36208 |
15(R)-Pinane Thromboxane A2
15(R)-Pinane Thromboxane A2 |
Others | Others |
15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle. | |||
T64391 |
Antiproliferative agent-15
|
Others | Others |
Antiproliferative agent-15是一种具有抗癌活性的试剂。Antiproliferative agent-15对人结肠癌(HCT116和HCT15)和脑癌(LN-229和GBM-10)具有抗增殖活性。 | |||
T22984 |
MJ 15
|
Cannabinoid Receptor | GPCR/G Protein |
MJ 15 是一种具有特异性的 CB1 受体拮抗剂,可用于研究肥胖引发的疾病。 | |||
T14497 |
BAM 15
|
OXPHOS; Mitochondrial Metabolism | Apoptosis; Metabolism |
BAM 15 是一种线粒体质子解偶联剂,也是一种氧化磷酸化解偶联剂。 | |||
T14185 |
Alkynyl Palmitic Acid
|
Others; PROTAC Linker | Others; PROTAC |
Alkynyl Palmitic Acid 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T3649 |
BGP-15
BGP15,BGP-15 2HCl |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
BGP-15 (BGP-15 2HCl) 是一种PARP 抑制剂,IC50和Ki 值分别为 120 和 57 μM,在缺血再灌注损伤后具有保护作用。 | |||
T5318 |
666-15
CREB inhibitor |
Epigenetic Reader Domain | Chromatin/Epigenetic |
666-15 (CREB inhibitor) 是一种选择性CREB 抑制剂,IC50为 81 nM,可抑制乳腺癌异种移植模型中的肿瘤生长。 | |||
T7389 |
G15
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
G15 是一种高亲和力的、选择性的 G 蛋白偶联雌激素受体(GPER/GPR30)拮抗剂(Ki:20 nM)。 | |||
T6855 |
HA15
|
Apoptosis; GPR; Others; HSP; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Others |
HA15 是一种高效特异性内质网伴侣蛋白BiP/GRP78/HSPA5抑制剂,抑制 BiP 的 ATP 酶活性,具有抗肿瘤活性。 | |||
TP1229 |
β-Amyloid (1-15)
Amyloid β-Protein (1-15) |
Beta Amyloid | Neuroscience |
β-Amyloid (1-15) (Amyloid β-Protein (1-15)) 是 β-淀粉样蛋白片段,可用于研究阿尔茨海默病。 | |||
T11024 |
DHODH-IN-15
|
Dehydrogenase | Metabolism |
DHODH-IN-15是一种 A771726 的 hydroxyfurazan 类似物。DHODH-IN-15 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂,对大鼠肝脏 DHODH 的 IC50 为 11 μM。DHODH-IN-15 可用于类风湿关节炎。 | |||
T37992 |
15-Methyl Palmitic Acid
15-Methylpalmitic acid,15-Methylhexadecanoic acid |
||
15-methyl Palmitic Acid 是一种一种甲基化脂肪酸,广泛存在于动物脂质中,可能于调节脂肪代谢有关。 | |||
T78210 |
STC-15
STC15 |
Others | Others |
STC-15 是一种具有口服活性和有效性的 METTL3 抑制剂,具有抗癌活性,可抑制癌症生长并诱导抗癌免疫。 | |||
T83649 |
VHL 15a
|
Others | Others |
T78183 |
B-Raf IN 15
|
Raf | MAPK |
B-Raf IN 15 是一种 BRAF 抑制剂,抑制 BRAFWT 和 BRAFV600E,可用于研究黑色素瘤和癌症,可用于优化成效果更好的BRA F抑制剂。 | |||
T19562 |
Polyethylene glycol 12-hydroxystearate
Solutol HS-15 |
Others | Others |
Polyethylene glycol 12-hydroxystearate (Solutol HS-15) 是一种通透性增强剂,是一种 Macrogol 15 羟基硬脂酸酯。 | |||
T60619 |
CDK9-IN-15
|
CDK | Cell Cycle/Checkpoint |
CDK9-IN-15 是一种有效的小分子CDK9抑制剂,可通过降解、抑制 CDK9 来阻断正性转录延长因子 P-TEFb (positive transcription elongation factor b) 对 RNA Poly-II C末端区域的磷酸化,抑制转录,迅速降低细胞内 mRNA 水平,从而引起肿瘤细胞凋亡。 | |||
T67883 |
EZH2-IN-15
SHR2554 |
Histone Methyltransferase | Chromatin/Epigenetic |
EZH2-IN-15 是zeste 2组蛋白修饰增强子(EZH2)的特异性抑制剂。EZH2在许多人类癌症中异常过表达,通过调节Treg 活性来控制适应性反应。肿瘤内EZH2的表达也被证明可以控制先天免疫 | |||
T61575 |
USP15-IN-1
|
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
USP15-IN-1 是一种有效的 USP15 抑制剂(IC50 为 3.76 μM)。USP15-IN-1对非小细胞肺癌和白血病细胞具有高度的抗增殖活性 。USP15是 cGAS 的互作蛋白,并且 USP15可以促进 cGAS 识别DNA 激活下游信号通路。 | |||
T11634 |
IL-15-IN-1
|
IL Receptor; Interleukin | Immunology/Inflammation |
IL-15-IN-1是一种 IL-15依赖性细胞的选择性抑制剂(IC50:0.8 μM)。 | |||
T24584 |
P505-15 Acetate
PRT 062607 Acetate,P505 15 Acetate,PRT-062607 Acetate,PRT062607 Acetate,P50515 Acetate |
Tyrosinase | Proteases/Proteasome |
P505-15 Acetate 是脾脏酪氨酸激酶的选择性抑制剂,通过抑制白细胞免疫功能和炎症起作用,导致关节炎评分降低和组织学损伤减轻。 | |||
T125334 |
15-Epi-Danshenol-A
|
Others | Others |
15-Epi-Danshenol-A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125334。 | |||
T23230 |
Rec 15/2615 dihydrochloride
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Rec 15/2615 dihydrochloride 是 α1B-adrenergic receptor 的拮抗剂。 | |||
T9990 |
c-Met-IN-15
|
Antibacterial | Microbiology/Virology |
c-Met-IN-15 具有抗菌活性。 | |||
T62606 |
ALOX15-IN-2
|
Lipoxygenase | Metabolism |
ALOX15-IN-2 是一种有效的 ALOX15 亚油酸加氧酶 (linoleate oxygenase) 活性抑制剂,抑制ALOX15 直系同源物亚油酸 (LA) 和花生四烯酸 (AA)进行氧化作用 , IC50 分别为 1.55 和 2.79 μM。 | |||
T1932 |
B-AP15
NSC 687852 |
Apoptosis; DUB | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
B-AP15 (NSC-687852) 是 26S 蛋白酶体的去泛素化酶 Usp14 和 UCHL5 的选择性抑制剂。 它阻断 26S 蛋白酶体的去泛素化活性。 | |||
T73164 |
SOS1-IN-15
|
Raf | MAPK |
SOS1-IN-15 是一种具有口服活性和高效性的 SOS1 抑制剂,具有潜在的抗肿瘤活性。SOS1-IN-15 可用于研究结肠癌。 | |||
T20494L |
Acetyl tetrapeptide-15 Acetate
Skinasensyl Acetate,Acetyl tetrapeptide-15 Acetate (928007-64-1 Free base) |
||
Acetyl tetrapeptide-15 Acetate (Skinasensyl Acetate) 是一种用于敏感皮肤的化妆品中的合成肽,是 endomorphin-2 衍生物, 通过内啡肽样通路扩大 μ-阿片受体中的神经元兴奋性阈值范围,可用于研究由皮肤高反应性产生的炎症性和神经性疼痛。 | |||
T8794 |
4-MMPB
15-Lipoxygenase Inhibitor 1 |
Apoptosis; Others; Lipoxygenase | Apoptosis; Metabolism; Others |
4-MMPB (15-Lipoxygenase Inhibitor 1) 是一种选择性15-脂氧合酶抑制剂,其 IC50值为 18 μM,具有前列腺癌的研究潜力。它对大豆 15-脂氧合酶和人 15-脂氧合酶-1 的 IC50 分别为 19.5 μM 和 19.1 μM。 | |||
T30677L |
C15AlkOPP t-BA salt
C15AlkOPP t-BA salt(946615-44-7 Free base),C15AlkOPP Tetrabutylamine salt(946615-44-7 Free base) |
Others | Others |
C15AlkOPP Tetrabutylamine salt 是一种"可点击"的farnesyl diphosphate (FPP)的炔烃修饰类似物。 | |||
TP1214L |
β-Amyloid 15-21 acetate
Beta-Amyloid (15-21) acetate |
Beta Amyloid | Neuroscience |
β-Amyloid 15-21 acetate (Beta-Amyloid(15-21) acetate) 是 Amyloid-β 肽的片段,可用于神经系统疾病的研究。该片段参与β折叠形成。 | |||
T30677L1 |
C15AlkOPP Tetrabutylamine salt (1:2)
C15AlkOPP Tetrabutylamine salt(1:2)(946615-44-7 Free base) |
Others | Others |
C15AlkOPP Tetrabutylamine salt (1:2)是一种FPP 类似物,具有炔基,允许前戊酰化后的蛋白质标记。C15AlkOPP Tetrabutylamine salt (1:2)可用于异戊二烯组学分析。 | |||
T83968 |
20-HETE Intermediate 15
Methyl (5Z,8Z,11Z,14Z)-20-(acetyloxy)-5,8,11,14-eicosatetraenoate |
||
20-HETE Intermediate 15 是20-羟基二十碳四烯酸的中间体。 | |||
T125414 |
15-Stachen-19-ol; Erythroxylol A; 15-Beyeren-19-ol
|
Others | Others |
15-Stachen-19-ol; Erythroxylol A; 15-Beyeren-19-ol 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125414,CAS号为 20107-90-8。 | |||
TP1975L |
[Ala11,D-Leu15]-Orexin B acetate
[Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) |
OX Receptor | GPCR/G Protein; Neuroscience |
[Ala11,D-Leu15]-Orexin B acetate 是一种特异性 orexin-2 受体 (OX2) 激动剂,EC50 为 0.13 nM,比 OX1 (52 nM) 特异性高 400 倍。 | |||
T8761L |
[Leu15]-Gastrin I human acetate(39024-57-2 Free base)
|
||
[Leu15]-Gastrin I human acetate(39024-57-2 Free base) 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T8761L。 | |||
T39400 |
JAK-IN-15
|
Others | Others |
JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15). | |||
T37401 |
15(S)-HpEDE
|
Others | Others |
15(S)-HpEDE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosadienoic acid. Although the biological activities of 15(S)-HpEDE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE (Cat. No. 44720). | |||
T37266 |
15(S)-HEPE
|
Others | Others |
15(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO. The biosynthesis of 15-HEPE from EPA in guinea pig epidermal enzyme preparations has been documented. 15(S)-HEPE generated by soybean lipoxygenation of EPA inhibits RBL-1 cell 5-LO with an IC50 value of 28 μM. | |||
T37233 |
(±)14(15)-EpEDE
|
Others | Others |
8,11,14-Eicosatrienoic acid, also known as dihomo-γ-linolenic acid , is a polyunsaturated fatty acid (PUFA) produced from γ-linolenic acid by the action of fatty acid elongases. It can be metabolized by the cyclooxygenase pathway to produce 1-series prostaglandins (PGs) (e.g., PGE1). (±)14(15)-EpEDE is an EpEDE acid formed from 8,11,14-eicosatrienoic acid. This monoepoxide can be generated from the PUFA, in vitro, by the action of a strong oxidizing agent. Alternatively, this compound may be pro... | |||
T35945 |
15-OxoETE
|
Others | Others |
15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE. Whether this is a major pathway of 15-HETE metabolism is yet to be clearly established. | |||
T37397 |
15(S)-HEDE
|
Others | Others |
15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO. 15(S)-HEDE is an inhibitor of RBL-1 cell 5-LO with an IC50 value of 26 μM. | |||
T35511 |
(±)15-HEPE
|
Others | Others |
(±)15-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 15(S)-HEPE and 15(R)-HEPE. Specific biological activity attributed to (±)15-HEPE has not been documented. | |||
T40093 |
IDO-IN-15
|
Others | Others |
IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM). | |||
T35510 |
(±)15-HEDE
|
Others | Others |
(±)15-HEDE is produced by non-enzymatic oxidation of 11,14-eicosadienoic acid. There are no reports in the literature of biological activity associated with (±)15-HEDE. | |||
T35943 |
15(S)-HpETE
|
Others | Others |
15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4 [1] or reduced to 15(S)-HETE by peroxidases.[2] [1] 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1. [3] 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inac... | |||
T40330 |
Anticancer agent 15
|
Others | Others |
Anticancer agent 15, an anticancer agent, exerts its efficacy by elevating intracellular levels of reactive oxygen species (ROS) and inducing cell death in melanoma cancer cells through necroptosis. | |||
T37234 |
(±)14(15)-EpETE
|
Others | Others |
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoi... | |||
T37402 |
15(S)-HpEPE
|
Others | Others |
15(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosapentaenoic acid. Although the biological activities of 15(S)-HpEPE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE (Catalog No. 44720). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2870 |
Matrine
Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine |
Mitophagy; Ferroptosis; Opioid Receptor; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱,可作为一种κ阿片受体激动剂,有抗肿瘤活性。 | |||
TN3594 |
Cardanol (C15:1)
|
Apoptosis; Others | Apoptosis; Others |
Cardanol (C15:1) 存在于腰果壳液中,可诱导人黑色素瘤细胞线粒体相关的细胞凋亡。 | |||
T38299 |
Tunicamycin V
|
Others | Others |
Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contains a 15-carbon N-acyl chain with variable branching patterns.References Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contains a 15-carbon N-acyl chain with variable branching patterns. References | |||
TN1965 |
N-Benzyllinolenamide
N-苄基-(9Z,12Z,15Z)-十八碳三烯酰胺,N-Benzyllinolenamide |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
N-Benzyllinolenamide 是从玛卡中得到的一种生物碱,是脂肪酰胺水解酶抑制剂,IC50 为 41.8 μM。 | |||
T14003 |
15-Acetoxyscirpenol
|
Caspase | Apoptosis; Proteases/Proteasome |
15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-dependent manner. This effect is mediated through the activation of caspases independent of caspase-3[1]. | |||
T80350 |
Maximin 15
|
Others | Others |
Maximin 15为源自蟾蜍大脑的抗菌肽,具有针对金黄色葡萄球菌、大肠杆菌和枯草芽孢杆菌的活性,其最小抑菌浓度(MIC)值依次为9.4, 18.8, 75 μg/mL。 | |||
T80862 |
Vitamin B15 hemicalcium
Pangamic Acid hemicalcium |
Others | Others |
Vitamin B15 (Pangamic Acid) hemicalcium 是一种自然存在于植物种子中的化合物,具有促进细胞呼吸的作用。它包含了D-葡萄糖基二甲基氨基乙酸,并可作为免疫校正剂。Vitamin B15 hemicalcium 在多种疾病研究中有应用。 | |||
TN3941 |
ent-17-Hydroxykaur-15-en-19-oic acid
|
Others | Others |
ent-17-Hydroxykaur-15-en-19-oic acid 是从香树叶中发现的天然化合物,对人前列腺细胞的IC50为17.63microg/mL。 | |||
T39385 |
15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid
|
Others | Others |
15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid is a Lanostane triterpenoid compound with the ability to inhibit NO production in LPS-induced microglia. | |||
T83660 |
3(Z),6(Z),9(Z),12(Z),15(Z)-Octadecapentaenoic Acid
C18:5 n-3,C18:5(3Z,6Z,9Z,12Z,15Z),all-cis-3,6,9,12,15-Octadecapentaenoic Acid |
Others | Others |
3(Z),6(Z),9(Z),12(Z),15(Z)-Octadecapentaenoic acid 是一种在 G. kowalevskii 中发现的微藻 PUFA,常作为微藻和甲藻的化学分类生物标志物使用。 | |||
TN7500 |
15,26-Dihydroxylanosta-7,9(11),24-trien-3-one
|
Others | Others |
T38892 |
3,11,15,23-Tetraoxo-27ξ-lanosta-8,16-dien-26-oic acid
|
Others | Others |
3,11,15,23-Tetraoxo-27ξ-lanosta-8,16-dien-26-oic acid, a lanostane-type triterpenoid, is extracted from Antrodia camphorate. | |||
TN1268 |
3β,7β,15β-Trihydroxy-11-oxo-lanosta-8-en-24→20 lactone
3Β,7Β,15Β-三羟基-11-羰基-羊毛甾烷-8-烯-24→20内酯,3beta,7beta,15beta-trihydroxy-11-oxo-lanosta-8-en-24->20 lactone |
Others | Others |
3beta,7beta,15beta-trihydroxy-11-oxo-lanosta-8-en-24->20 lactone is a natural product | |||
T83447 |
15-Nor-14-oxolabda-8(17),12E-Diene-18-oic acid
|
Others | Others |
15-Nor-14-oxolabda-8(17),12E-Diene-18-oic acid (compound 9) 为从Chloranthus spicatus提取的化学化合物。 | |||
T81950 |
Lanosta-7,9(11),24-trien-3β,15α-dihydrcxy-26-oic acid
|
||
Lanosta-7,9(11),24-trien-3β,15α-dihydroxy-26-oic acid (compound 2),一种从中药真菌Ganoderma lucidum中分离的天然产物。 | |||
TN1964 |
N-(3-Methoxybenzyl)(9Z,12Z,15Z)-octadeca-9,12,15-trienamide
N-间氧基苄基-9顺-12顺-15顺-亚麻酸酰胺(玛卡酰胺 5),玛卡酰胺 5 |
Others | Others |
N-(3-Methoxybenzyl)(9Z,12Z,15Z)-octadeca-9,12,15-trienamide is a natural product | |||
T83442 |
17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene
|
||
17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene是一款具有抗炎特性的天然倍半萜内酯。 | |||
T83420 |
1α, 2α-Diacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-15-β-(β-furancarbonyloxy)-4β, 6β-dihydroxy-β-dihydroagarofuran
|
||
1α, 2α-Diacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-15-β-(β-furancarbonyloxy)-4β, 6β-dihydroxy-β-dihydroagarofuran(化合物7)是Pseudolarix kaempferi根皮中发现的一种倍半萜类化合物。 | |||
T83446 |
15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide
|
||
15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (compound 2), 一种从冬凌草提取的ent-kaurene diterpenoid,显示了对多个细胞系的细胞毒性作用。具体而言,其对EC-1、U87、A549、MCF-7 和 Hela 细胞系的IC50值分别为37.69 μM、79.362 μM、80.07 μM、197.35 μM、462.13 μM 和180.09 μM。 | |||
T39386 |
(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid
|
Others | Others |
(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoid, demonstrates significant inhibitory effects on nitric oxide (NO) production in BV-2 microglia cells induced by n LPS, with an IC50 value of 9.55 uM. Moreover, this compound possesses anti-inflammatory properties. | |||
TN2042 |
Paniculoside II
|
Others | Others |
Paniculoside II is a natural product from Stevia rebaudiana. | |||
T8002 |
3-Hydroxycoumarin
|
Lipoxygenase | Metabolism |
3-hydroxycoumarin 是一种 15-LOX-1的有效氧化还原抑制剂,近期被证明能保护海胆生殖细胞免受紫外线 B 的损伤。 | |||
T14865 |
Carboprost tromethamine
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Carboprost tromethamine 是合成的前列腺素 F2α的15-甲基类似物,能有效促进子宫的规律收缩,显着减少产中及产后出血量。 | |||
T6680 |
Staurosporine
Antibiotic AM-2282,星形孢菌素,AM-2282,CGP 41251,星孢菌素 |
Apoptosis; PKA; Antibacterial; Antibiotic; Src; PKC; Antifungal | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Staurosporine (AM-2282) 是一种蛋白激酶抑制剂,对 PKC、PKA、c-Fgr、Phosphorylase kinase 和 TAOK2 均有抑制活性 (IC50=6/15/2/3/3000 nM),具有 ATP 竞争性和非选择性。Staurosporine 也可以诱导凋亡。 | |||
T3030 |
L-Sophoridine
L-槐定碱,Sophoridine,Matridin-15-one |
Others | Others |
L-Sophoridine (Matridin-15-one) 一种从药用植物中提取的天然产物,具有多种药理作用,包括抗Y 作用,可在体外和体内选择性诱导多种人体Y 细胞凋亡;然而,其作用机制需要进一步阐述。 | |||
T37974 |
(S)-Coriolic acid
13(S)-HODE |
Lipoxygenase; Mitochondrial Metabolism; PPAR | DNA Damage/DNA Repair; Metabolism |
(S)-Coriolic acid (13(S)-HODE) 是一种重要的细胞内信号剂,是亚油酸与植物和哺乳动物脂氧合酶反应生成的,在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 在 1 μM 左右时,它能抑制肿瘤细胞与血管内皮的粘附,能下调 IRGpIIb/IIIa 受体的表达。(S)-Coriolic acid 是15-脂氧合酶 (15-LOX) 代谢产物,常作为内源性配体激活 PPARγ。(S)-Coriolic acid 诱导线粒体功能障碍 和气道上皮损伤。 | |||
T8049 |
Pentadecanoic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Pentadecanoic acid 是一个具有 15 个碳主链的饱和脂肪酸。 | |||
T5214 |
Cholesteryl linoleate
CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester,胆甾烯基亚油酸酯 |
Others; Endogenous Metabolite | Metabolism; Others |
Cholesteryl linoleate 是低密度脂蛋白和动脉粥样硬化病变中主要的胆固醇酯。它存在于 LDL 中的胆固醇酯,利用 LDL 受体相关蛋白转移到表达 15-脂氧合酶的巨噬细胞和 CHO 细胞的质膜,被氧化形成胆固醇亚油酸氢过氧化物。 | |||
TN6864 |
Prosaikogenin F
前柴胡皂苷F |
Others | Others |
Prosaikogenin F ((2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol) 是一种单糖苷,具有溶血和抗癌特性。 | |||
T2783 |
Methyl dihydrojasmonate
Methyl Dihydrojasmonate,Kharismal,Hedione,二氢茉莉酮酸甲酯 |
Others | Others |
Methyl dihydrojasmonate (Kharismal) 是一种香料成分,具有茉莉花香气,常用于许多香料混合物中。 | |||
TN1787 |
Isomucronulatol 7-O-glucoside
Isomucronulatol 7-O-beta-glucoside,黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷 |
Others | Others |
Isomucronulatol 7-O-beta-glucoside 具有潜在的抗炎活性,在体外对 LPS 刺激产生的 IL-12 p40 表现出微弱的抑制作用。 | |||
T6862 |
Isatin
Pseudoisatin,板蓝根,Indoline-2,3-dione,2,3-Indolinedione |
Apoptosis; MAO; Monoamine Oxidase | Apoptosis; Metabolism; Neuroscience |
Isatin (2,3-Indolinedione) 是一种单胺氧化酶抑制剂,IC50为3 μM。它也可作为心钠肽刺激和一氧化氮刺激的鸟苷酸环化酶活性的拮抗剂,显示对血清素系统有影响。 | |||
TN1516 |
Cnidicin
蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮 |
NOS; NO Synthase | Immunology/Inflammation |
Cnidicin 是一种香豆素,对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。 | |||
T5980 |
2-Ketoglutaric acid
α-酮戊二酸,alpha-酮戊二酸 |
Tyrosinase; Endogenous Metabolite | Metabolism; Proteases/Proteasome |
2-Ketoglutaric acid 是 Krebs 循环的中间体,可以产生 ATP 或 GTP 。2-Ketoglutaric acid 还充当氮同化反应的主要碳骨架。2-Ketoglutaric acid 是酪氨酸酶(tyrosinase)的可逆抑制剂 (IC50=15 mM)。 | |||
T5S1897 |
Linderalactone
|
Apoptosis; Others; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells |
Linderalactone 是从乌药中分离出来的一种倍半萜烯内酯,通过调节凋亡相关蛋白的表达和抑制 JAK/STAT 信号通路来抑制癌细胞生长。它以 IC50值为 15 µM 来抑制肺癌 A-549 细胞的增殖。 | |||
T3929 |
Kaurenoic acid
Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid |
Others | Others |
Kaurenoic acid (kaurenoate) 是一种二萜,来源于 Sphagneticola trilobata 中,可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路,并抑制炎症疼痛。 | |||
T27651 |
JBIR-15
|
Others | Others |
JBIR-15, a fungal metabolite, demonstrates antifungal activity against C.albicans. | |||
TN5947 |
3-Dehydro-15-deoxoeucosterol
17,23-Epoxy-29-hydroxy-27-norlanost-8-ene-3,24-dione |
||
3-Dehydro-15-deoxoeucosterol is a natural product from Scilla scilloides. | |||
TN2635 |
15-Demethylplumieride
|
Others | Others |
15-Demethylplumieride is a quality control index of Plumeriarubra L. | |||
T22473 |
15-deoxy-Δ-12,14-Prostaglandin J2
|
Others | Others |
15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist. | |||
TN4030 |
Eudesm-4(15)-ene-3alpha,11-diol
|
||
Eudesm-4(15)-ene-3alpha,11-diol 是一种来源于Eudesm-4(15)-ene-3alpha,11-diol 的化合物。 | |||
TN2636 |
15-Deoxoeucosterol
|
Others | Others |
15-Deoxoeucosterol是一种天然产物,属于天门冬科蓝瑰花属,其产品编号为 TN2636,CAS号为 81241-53-4。15-Deoxoeucosterol可用作对照参考。 | |||
TMA0164 |
15-Hydroxydehydroabietic acid
|
P450; Antifection | Metabolism; Microbiology/Virology |
15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities. | |||
T10045 |
15-Acetyl-deoxynivalenol
|
Others | Others |
15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals and exhibits toxicity to HepG2 cells. | |||
TN6526 |
15-Methoxy-16-oxo-15,16H-strictic acid
|
||
15-Methoxy-16-oxo-15,16H-strictic acid是一种天然产物,属于菊科蚤草属,其产品编号为 TN6526,CAS号为 1356388-38-9。15-Methoxy-16-oxo-15,16H-strictic acid可用作对照参考。 | |||
TN6525 |
15-Deoxypulic acid
|
||
15-Deoxypulic acid是一种天然产物,属于菊科蚤草属,其产品编号为 TN6525,CAS号为 95523-05-0。15-Deoxypulic acid可用作对照参考。 | |||
TN2638 |
15-Hydroxy-7-oxodehydroabietic acid
|
Others | Others |
15-Hydroxy-7-oxodehydroabietic acid是一种天然产物,属于松科松属,其产品编号为 TN2638,CAS号为 95416-25-4。15-Hydroxy-7-oxodehydroabietic acid可用作对照参考。 | |||
TN2648 |
16-Nor-15-oxodehydroabietic acid
|
Others | Others |
16-Nor-15-oxodehydroabietic acid is a natural product from Pinus massoniana. | |||
TN6478 |
(-)-Cadin-4,10(15)-dien-11-oic acid
|
||
(-)-Cadin-4,10(15)-dien-11-oic acid是一种天然产物,属于天南星科菖蒲属,其产品编号为 TN6478,CAS号为 1124353-23-6。(-)-Cadin-4,10(15)-dien-11-oic acid可用作对照参考。 | |||
TMA0692 |
Diosbulbin G
山药 |
Others | Others |
Diosbulbin G是一种天然产物,属于薯蓣科薯蓣属,其产品编号为 TMA0692,CAS号为 67567-15-1。Diosbulbin G可用作对照参考。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01461 |
IL-15RA & IL-15 Protein, Human, Recombinant (hFc)
IL-15 Receptor α & IL-15 Fusion Protein,In... |
Human | HEK293 Cells |
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... | |||
TMPJ-01462 |
IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)
IL15,IL15RA&IL15,IL-... |
Human | HEK293 Cells |
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... | |||
TMPY-04632 |
IL-15 Protein, Human, Recombinant
白细胞介素,IL-15,白介素,interleukin 15 |
Human | E. coli |
IL-15 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.8 kDa and the accession number is P40933-1. | |||
TMPY-04727 |
GDF-15 Protein, Human, Recombinant (His)
PLAB,PTGFB,NAG-1,MIC1,GDF-15,PDF,... |
Human | P. pastoris (Yeast) |
GDF-15 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 13.7 kDa and the accession number is Q99988. | |||
TMPK-01243 |
GDF-15 Protein, Rat, Recombinant (His)
GDF-15,PDF,PTGF-beta,MIC-1,MIC1,GDF15<... |
Rat | E. coli |
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.68 kDa and the accession number is Q9Z0J6. | |||
TMPK-01246 |
GDF-15 Protein, Mouse, Recombinant (His)
MIC1,Placental TGF-beta,Pla |
Mouse | E. coli |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec... | |||
TMPY-04333 |
LRRC15 Protein, Human, Recombinant (hFc)
leucine rich repeat containing 15... |
Human | HEK293 Cells |
LRRC15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.5 kDa and the accession number is Q8TF66-1. | |||
TMPY-05526 |
Siglec-15 Protein, Human, Recombinant (His)
SIGLEC-15,sialic acid binding Ig-... |
Human | HEK293 Cells |
Siglec-15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.7 kDa and the accession number is Q6ZMC9-1. | |||
TMPY-01073 |
GDF-15 Protein, Human, Recombinant (hFc)
PTGFB,PLAB,MIC-1,MIC1,PDF,NAG-1,growth dif... |
Human | HEK293 Cells |
GDF-15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is Q99988. | |||
TMPJ-00603 |
TL1A/TNFSF15 Protein, Mouse, Recombinant
TNFSF15,Tumor Necrosis Factor Liga |
Mouse | E. coli |
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial ... | |||
TMPJ-01099 |
IL-15RA Protein, Human, Recombinant (hFc, Human Cells)
interleukin-15 receptor subunit α,IL15R |
Human | HEK293 Cells |
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun... | |||
TMPJ-00154 |
IL-15RA Protein, Mouse, Recombinant (hFc, Human Cells)
sIL-15 receptor subunit α,Il15ra,... |
Mouse | HEK293 Cells |
Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il... | |||
TMPY-04645 |
TL1A/TNFSF15 Protein, Human, Recombinant (hFc)
TL1,tumor necrosis factor (ligand) superf<... |
Human | HEK293 Cells |
TL1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is A0A0U5JA19. | |||
TMPY-03871 |
TM4SF2/TSPAN7 Protein, Mouse, Recombinant (His)
AI323365,Tm4sf2,PE31,A15,R74651,T... |
Mouse | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPY-04325 |
Influenza A H3N2 (A/Wisconsin/15/2009) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma vir |
H3N2 | HEK293 Cells |
Influenza A H3N2 (A/Wisconsin/15/2009) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is I6TE52. | |||
TMPY-03862 |
TM4SF2/TSPAN7 Protein, Human, Recombinant (His)
TM4SF2,A15,MXS1,tetraspa... |
Human | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPY-05924 |
Influenza A H1N1 (A/swine/Iowa/15/1930) Neuraminidase/NA Protein (His)
NA Protein |
H1N1 | HEK293 Cells |
Influenza A H1N1 (A/swine/Iowa/15/1930) Neuraminidase/NA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.3 kDa and the accession number is Q9IBI2. | |||
TMPY-06608 |
Kallikrein 15/KLK15 Protein, Mouse, Recombinant (His)
kallikrein-related peptidase ... |
Mouse | HEK293 Cells |
Kallikrein 15/KLK15 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.96 kDa and the accession number is NP_777354.1. | |||
TMPY-05289 |
Kallikrein 15/KLK15 Protein, Human, Recombinant (His)
ACO,HSRNASPH,kallikrein-rela<... |
Human | HEK293 Cells |
Kallikrein 15/KLK15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.8 kDa and the accession number is Q9H2R5-1. | |||
TMPY-00491 |
Kallikrein 15/KLK15 Protein, Human, Recombinant (hFc)
ACO,kallikrein-related peptid... |
Human | HEK293 Cells |
Kallikrein 15/KLK15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q9H2R5-1. | |||
TMPJ-00565 |
Mucin-15/MUC15 Protein, Human, Recombinant (His)
MUC15,Mucin-15,MUC-15 |
Human | HEK293 Cells |
Mucin-15 is a single-pass type I membrane protein member of the Mucin family. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoans. A key characteristic of Mucins is their ability to form gels. Therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. Mucin-15 is expressed in many tissues. Mucin-15 is highly glycosylat... | |||
TMPY-02001 |
RTN4 Protein, Human, Recombinant (GST)
UNG1,NOGO,reticulon 4,RTN4-A,Nbla00271,NOG... |
Human | E. coli |
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 ... | |||
TMPY-06531 |
IL-15 & IL-15RA Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 Cells |
IL-15 & IL-15RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.46 kDa and the accession number is P48346-1 & Q60819-1. | |||
TMPY-06020 |
IL-15 & IL-15RA Protein, Human, Recombinant (hFc)
|
Human | HEK293 Cells |
IL-15 & IL-15RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is NP_002180.1&NP_000576.1. | |||
TMPJ-01125 |
PEA15 Protein, Human, Recombinant
15 kDa Phosphoprotein Enriched in A |
Human | E. coli |
Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm... | |||
TMPY-03553 |
15 Lipoxygenase 2 Protein, Human, Recombinant
arachidonate 15-lipoxyge... |
Human | Baculovirus Insect Cells |
15 Lipoxygenase 2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 76 kDa and the accession number is AAH35217.1. | |||
TMPY-02348 |
ISG15 Protein, Human, Recombinant
ISG15 ubiquitin-like modifier,hUCRP,IP17,IFI15<... |
Human | E. coli |
ISG15 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.9 kDa and the accession number is AAH09507.1. | |||
TMPK-00665 |
GDF-15 Protein, Cynomolgus, Recombinant (His)
PTGFBPTGF-beta,PTGFBPTGF-β,MIC-1,NAG-1,MIC... |
Cynomolgus | E. coli |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus... | |||
TMPK-00663 |
GDF-15 Protein, Cynomolgus, Recombinant (hFc)
PTGF-β,GDF-15,NAG-1,PTGF-beta,PDF... |
Cynomolgus | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus... | |||
TMPJ-01394 |
CXCL15 Protein, Mouse, Recombinant (His)
Lungkine,C-X-C motif chemokine 15,Small-in... |
Mouse | HEK293 Cells |
Mouse C-X-C motif chemokine 15, also known as Cxcl15, is a secreted protein which is member of the ELR motif-containing CXC chemokines. It expressed at low levels in fetal lung, the expression restricted to the lung, produced by bronchoepithelial cells and is released into the airways. It plays an important role in lung-specific neutrophil trafficking during normal and inflammatory conditions. It also appears chemotactic for neutrophils. | |||
TMPJ-00225 |
Siglec-15 Protein, Mouse, Recombinant (His)
Siglec-15,Sialic acid-binding Ig-... |
Mouse | HEK293 Cells |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type I... | |||
TMPK-01244 |
GDF-15 Protein, Mouse, Recombinant (hFc)
PTGFBPTGF-beta,PTGFB,PLAB,NAG-1,P... |
Mouse | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec... | |||
TMPK-00569 |
GDF-15 Protein, Canine, Recombinant (His)
GDF15,MIC1,MIC-1,PLAB,GDF-15,PDF,... |
Canine | E. coli |
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Canine, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.12 kDa and the accession number is A0A8C0TNP6. | |||
TMPY-06148 |
LRRC15 Protein, Human, Recombinant (His)
leucine rich repeat containing 15... |
Human | HEK293 Cells |
LRRC15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is Q8TF66-1. | |||
TMPY-01264 |
15-PGDH Protein, Human, Recombinant (His)
PGDH1,hydroxyprostaglandin dehydrogena... |
Human | E. coli |
15-PGDH Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 29.7 kDa and the accession number is P15428-1. | |||
TMPY-05835 |
Siglec-15 Protein, Mouse, Recombinant (rFc)
Cd33l3,SIGLEC-I,EG620235,sialic acid bindi... |
Mouse | HEK293 Cells |
Siglec-15 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 50.83 kDa and the accession number is A7E1W8. | |||
TMPK-01070 |
LRRC15 Protein, Mouse, Recombinant (His)
LIB,LRRC15 |
Mouse | HEK293 Cells |
The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. LRRC15 Prote... | |||
TMPJ-01189 |
S100A15A Protein, Mouse, Recombinant
Protein S100-A15A,S100 ca |
Mouse | E. coli |
Members of the S100 protein family are involved in calcium- or zinc-dependent cellular functions and regulate immune-mechanisms, cell proliferation and differentiation. Some S100 members have been established as tumor markers because they are dysregulated during carcinogenesis. Psoriasin (S100A7) and koebnerisin (S100A15) are highly homologous proteins that have been first described in psoriasis, which is characterized by disturbed epidermal maturation and chronic inflammation. Several studies s... | |||
TMPK-01309 |
LRRC15 Protein, Canine, Recombinant (His)
LIB,LRRC15 |
Canine | HEK293 Cells |
The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. LRRC15 Prote... | |||
TMPH-02963 |
ISG15 Protein, Mouse, Recombinant (His)
Ubiquitin-like protein ISG15,Interferon-induced 17 ... |
Mouse | P. pastoris (Yeast) |
ISG15 Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 18.9 kDa and the accession number is Q64339. | |||
TMPY-01707 |
CHST15 Protein, Human, Recombinant (His)
BRAG,carbohydrate (N-ace... |
Human | HEK293 Cells |
Carbohydrate sulfotransferase 15, also known as N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase, GalNAc4S-6ST, B-cell RAG-associated gene protein, CHST15 and BRAG, is a single-pass type II membrane protein which belongs to thesulfotransferase 1 family. CHST15 / BRAG is expressed in B-cell-enriched tissues but not in fetal or adult thymus. It is expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. It is not expressed in T-cells. In pro-B, pre... | |||
TMPY-06627 |
Asp f 15 Protein, Aspergillus Fumigatus, Recombinant
|
Aspergillus Fumigatus | E. coli |
Asp f 15 Protein, Aspergillus Fumigatus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa. | |||
TMPY-04049 |
IL-15 Protein, Human, Recombinant (His)
interleukin 15,白细胞介素,白介素,IL-15 |
Human | E. coli |
IL-15 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P40933-1. | |||
TMPY-06696 |
TXNDC15 Protein, Human, Recombinant (His)
UNQ335,thioredoxin domain containing 1... |
Human | HEK293 Cells |
TXNDC15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.96 kDa and the accession number is NP_078991.3. | |||
TMPY-05678 |
Siglec-15 Protein, Cynomolgus, Recombinant (hFc)
sialic acid binding Ig-like lectin 15<... |
Cynomolgus | HEK293 Cells |
Siglec-15 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53 kDa and the accession number is A0A2K5UY47. | |||
TMPY-00961 |
ADAM15 Protein, Human, Recombinant (His)
MDC15,ADAM metallopeptid... |
Human | HEK293 Cells |
ADAM15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is Q13444-10. | |||
TMPY-02273 |
15-PGDH Protein, Mouse, Recombinant (His)
15-PGDH,AV026552,hydroxyprostagl<... |
Mouse | E. coli |
15-PGDH Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30.6 kDa and the accession number is Q8VCC1. | |||
TMPY-05736 |
Siglec-15 Protein, Human, Recombinant (mFc)
HsT1361,SIGLEC-15,CD33L3,sialic a... |
Human | HEK293 Cells |
Siglec-15 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 52.79 kDa and the accession number is Q6ZMC9-1. | |||
TMPY-02280 |
ADAM15 Protein, Mouse, Recombinant (His)
metargidin,ADAM metallop... |
Mouse | HEK293 Cells |
ADAM15 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.6 kDa and the accession number is O88839-1. | |||
TMPJ-00434 |
Siglec-15 Protein, Cynomolgus, Recombinant (His)
Siglec-15,CD33L3,Sialic acid-bind... |
Cynomolgus | HEK293 Cells |
Siglec-15 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is A0A2K5UY47. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T40376 |
L-Phenylalanine-15N
L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是 15N 标记的 L-Phenylalanine。L-Phenylalanine 是从大肠杆菌中分离出来的一种必需氨基酸。 L-Phenylalanine 广泛用于食品香精和药物的生产。 | |||
TMIJ-0435 |
Octanoic Acid-d15
|
||
Octanoic Acid-d15 是 Octanoic Acid 的氘代化合物。Octanoic Acid 的 CAS 号为 124-07-2。Caprylic acid天然存在于椰子和母乳中。它是一种油性液体,带有些许腐臭味,能用于酯类香料和染料的生产。 | |||
T40394 |
Benzamide-15N
Phenylamide-15N,Benzenecarboxamide-15N,NSC-3114-15N,Benzamide-15N |
||
Benzamide-15N (NSC-3114-15N) is a 15N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP). | |||
TMID-0120 |
Valproic Acid-d15
|
||
Valproic Acid-d15 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂,可抑制HDAC1的活性,同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。 | |||
T35513 |
13C15-Nivalenol
13C15-Nivalenol |
||
13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/kg).2Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3 1.Yang, Z., Concannon, J., Ng, K.S., et al.Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulationSci. Rep.63026... | |||
TMID-0122 |
Uric acid-13C-15N2
|
||
Uric acid-13C-15N2 是 Uric acid 的 13C 和 15 N 的标记化合物。Uric acid 的 CAS 号为 69-93-2。Uric acid 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ,如单线态氧和过氧亚硝酸盐,抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。 | |||
TMIJ-0399 |
Triphenyl-d15 Phosphate
|
||
Triphenyl-d15 Phosphate 是 Triphenyl Phosphate 的氘代化合物。Triphenyl Phosphate 的 CAS 号为 115-86-6。 | |||
T39441 |
L-Arginine-15N4 hydrochloride
L-Arginine-15N4 hydrochloride,(S)-(+)-Arginine-15N4 hydrochloride |
||
L-Arginine-15N4 ((S)-(+)-Arginine-15N4) hydrochloride, the 15N-labeled variant of L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride), serves as the nitrogen donor in the synthesis of nitric oxide. This potent vasodilator is crucial, especially during a sickle cell crisis where its levels are notably diminished. | |||
T39565 |
L-Glutamic acid-15N
|
||
L-Glutamic acid-15N is the 15N-labeled version of L-Glutamic acid, an excitatory neurotransmitter and an agonist at metabotropic, kainate, NMDA, and AMPA glutamate receptor subtypes. It directly activates the release of dopamine (DA) from dopaminergic terminals. | |||
T35591 |
Guanfacine-13C,15N3
Guanfacine-13C,15N3 |
||
Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin... | |||
T38118 |
Zanamivir-13C,15N2
Zanamivir-13C,15N2 |
||
Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50values ranging from 0.6 to 7.9 nMin vitro. Intra... | |||
TMIJ-0030 |
1-Aminoadamantane-d15
|
||
1-Aminoadamantane-d15 是 1-Aminoadamantane 的氘代化合物。1-Aminoadamantane 的 CAS 号为 768-94-5。Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 | |||
T35517 |
4-deoxy Nivalenol-13C15
4-deoxy Nivalenol-13C15 |
||
4-deoxy Nivalenol-13C15is intended for use as an internal standard for the quantification of 4-deoxy nivalenol by GC- or LC-MS. 4-deoxy Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (0.1 and 0.2 mg/kg) induces emesis in pigs and decreases feed consumption in pigs when administered at a dose of 40 ppb in the diet.2It induces leth... | |||
T37608 |
Riluzole-13C,15N2
Riluzole-13C,15N2 |
||
Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a... | |||
T36895 |
5-Fluorouracil-13C,15N2
5-Fluorouracil-13C,15N2 |
||
5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. | |||
TMIH-0506 |
Roxadustat-13C-15N
|
||
Roxadustat-13C-15N 是 Roxadustat 的 13C 和 15N 的标记化合物。 | |||
TMIJ-0267 |
Upadacitinib-15N-d2
|
||
Upadacitinib-15N-d2 是 Upadacitinib 的 15N 和氘代化合物。Upadacitinib 的 CAS 号为 1310726-60-3。Upadacitinib 是高效选择性的,具有口服活性的JAK1抑制剂,IC50为43 nM,可用于多种自身免疫性疾病的研究。它对 JAK1 的选择性约为 JAK2 的 74 倍。 | |||
TMIJ-0170 |
Cefdinir-13C-15N2
|
||
Cefdinir-13C-15N2 是 Cefdinir 的 13C 和 15 N 的标记化合物。Cefdinir 的 CAS 号为 91832-40-5。Cefdinir是头孢菌素类中的一种半合成广谱抗生素,对几种革兰氏阴性和革兰氏阳性细菌引起的感染有效。它可研究耳,鼻窦,喉咙和皮肤的常见细菌感染。 | |||
TMIJ-0448 |
Glyphosate-13C2-15N
|
||
Glyphosate-13C2-15N 是 Glyphosate 的 13C 和 15 N 的标记化合物。Glyphosate 的 CAS 号为 1071-83-6。Glyphosate 是氨基酸甘氨酸的衍生物。它是一种除草剂,靶向并阻断植物合成芳香氨基酸所必需的莽草酸途径。 | |||
TMIJ-0524 |
Triethanolamine-d15
|
||
Triethanolamine-d15 是 Triethanolamine 的氘代化合物。Triethanolamine 的 CAS 号为 102-71-6。 | |||
TMIJ-0381 |
L-Valine-13C5-15N
|
||
L-Valine-13C5-15N 是 L-Valine 的 13C 和 15 N 的标记化合物。L-Valine 的 CAS 号为 72-18-4。L-Valine 是蛋白二十种氨基酸中的其中一种。它是必需氨基酸。 | |||
TMIH-0591 |
Vadadustat-13C2-15N
|
||
Vadadustat-13C2-15N 是 Vadadustat 的 13C 和 15N 的标记化合物。Vadadustat 的 CAS 号为 1000025-07-9。Vadadustat 是一种可滴定口服的缺氧诱导因子脯氨酰羟化酶 (HIF-PH) 抑制剂,是一种促红细胞生成剂,在动物慢性肾脏疾病模型中,有用于贫血的研究潜力。 | |||
TMIJ-0311 |
Tranexamic Acid-13C2-15N
|
||
Tranexamic Acid-13C2-15N 是 Tranexamic Acid 的 13C 和 15 N 的标记化合物。Tranexamic Acid 的 CAS 号为 1197-18-8。Amstat 是一种能阻断纤溶酶的赖氨酸结合位点和弹性蛋白酶来源的纤维蛋白溶酶原片段。 | |||
TMIH-0507 |
Roxadustat-13C2-15N
|
||
Roxadustat-13C2-15N 是 Roxadustat 的 13C 和 15N 的标记化合物。 | |||
T40874 |
2-Nitrobenzaldehyde semicarbazone 13C,15N2
2-Nitrobenzaldehyde semicarbazone 13C,15N2 |
||
2-Nitrobenzaldehyde semicarbazone (13C, 15N2) is utilized in the LC-MS/MS method for semicarbazide analysis. | |||
TMIJ-0331 |
Amantadine-d15 Hydrochloride
|
||
Amantadine-d15 Hydrochloride 是 Amantadine Hydrochloride 的氘代化合物。Amantadine Hydrochloride 的 CAS 号为 665-66-7。Amantadine hydrochloride是一种抗病毒药物,用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道,从而阻止病毒 RNA 释放到感染细胞的细胞质中。 | |||
TMIJ-0517 |
3,5-Dinitrosalicylhydrazide-15N2
|
||
3,5-Dinitrosalicylhydrazide-15N2 是 3,5-Dinitrosalicylhydrazide 的 13C 和氘代化合物。 | |||
TMIJ-0010 |
Semicarbazide-13C-15N2 Hydrochloride
|
||
Semicarbazide-13C-15N2 Hydrochloride 是 Semicarbazide Hydrochloride 的 13C 和 15 N 的标记化合物。Semicarbazide Hydrochloride 的 CAS 号为 563-41-7。Semicarbazide hydrochloride 是一种尿素衍生物,能够与细胞中的铜或铁结合,产生抗病毒、抗感染和抗肿瘤作用。 | |||
TMIJ-0190 |
Gemcitabine EP Impurity C-13C-15N2
|
||
Gemcitabine EP Impurity C-13C-15N2 是 Gemcitabine EP Impurity C 的 13C 和 15 N 的标记化合物。 | |||
TMIJ-0380 |
L-Lysine-13C6-15N2 Hydrochloride
|
||
L-Lysine-13C6-15N2 Hydrochloride 是 L-Lysine Hydrochloride 的 13C 和 15 N 的标记化合物。L-Lysine Hydrochloride 的 CAS 号为 657-27-2。L-lysine hydrochloride 是一种人类必需氨基酸,能增加钙吸收,减少糖尿病相关疾病和改善肠道健康,可用于疱疹的研究。 | |||
TMIJ-0165 |
Glutathione-(glyucine-13C2-15N) Trifluoroacetate
|
||
Glutathione-(glyucine-13C2-15N) Trifluoroacetate 是 Glutathione Trifluoroacetate 的 13C 和 15 N 的标记化合物。 | |||
TMID-0277 |
4-AcetaMido-d3-antipyrine
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4-AcetaMido-d3-antipyrine 是 4-AcetaMido-antipyrine 的氘代化合物。4-AcetaMido-antipyrine 的 CAS 号为 83-15-8。 | |||
TMIH-0441 |
Piroxicam EP Impurity J-d3
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Piroxicam EP Impurity J-d3 是 Piroxicam EP Impurity J 的氘代化合物。Piroxicam EP Impurity J 的 CAS 号为 35511-15-0。 | |||
TMIH-0218 |
Enzalutamide-d6 Carboxylic Acid
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Enzalutamide-d6 Carboxylic Acid 是 Enzalutamide Carboxylic Acid 的氘代化合物。Enzalutamide Carboxylic Acid 的 CAS 号为 1242137-15-0。Enzalutamide carboxylic acid 是 Enzalutamide 非活性代谢物。Enzalutamide 是雄激素受体 (AR) 拮抗剂。 | |||
TMIJ-0408 |
1-Naphthol-d8
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1-Naphthol-d8 是 1-Naphthol 的氘代化合物。1-Naphthol 的 CAS 号为 90-15-3。1-naphthol 是激发态质子转移荧光分子探针。 | |||
TMIJ-0295 |
Flubendazole-d3 (methyl-d3)
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Flubendazole-d3 (methyl-d3) 是 Flubendazole 的氘代化合物。Flubendazole 的 CAS 号为 31430-15-6。Flubendazole 是用于治疗人类蠕虫感染的驱虫药。它通过抑制微管功能等机制发挥抗癌作用。它诱导p53介导的细胞凋亡,抑制 G2/M 细胞周期。 | |||
T71205 |
Fosinopril-d7 sodium salt
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Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti... | |||
T13308 |
Vortioxetine D8
Lu AA 21004 D8 |
Others | Others |
Vortioxetine D8 is a deuterium labeled Vortioxetine. Vortioxetine is an 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT inhibitor (Kis: 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively). | |||
TMID-0029 |
Succinic-2,2,3,3-d4 Acid
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Succinic-2,2,3,3-d4 Acid 是 Succinic Acid 的氘代化合物。Succinic Acid 的 CAS 号为 110-15-6。Succinic acid 是无氧代谢的发酵产物,也是三羧酸循环的中间产物。 | |||
TMIJ-0090 |
L-Carnitine-d9
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L-Carnitine-d9 是 L-Carnitine 的氘代化合物。L-Carnitine 的 CAS 号为 541-15-1。L-carnitine 是一种人内源性分子,在人体内以蛋氨酸和赖氨酸为底物进行生物合成,并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。 | |||
TMIJ-0135 |
Abiraterone-d4
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Abiraterone-d4 是 Abiraterone 的氘代化合物。Abiraterone 的 CAS 号为 154229-19-3。Abiraterone 是不可逆的CYP17A1抑制剂,具有抗雄激素作用,抑制细胞色素 p450 酶 CYP17 的 17α-羟化酶 (IC50:2.5 nM) 和 17,20-裂合酶 (IC50:15 nM) 活性。 | |||
TMIJ-0130 |
Vortioxetine-d8
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Vortioxetine-d8 是 Vortioxetine 的氘代化合物。Vortioxetine 的 CAS 号为 508233-74-7。Vortioxetine 是5-HT1A、5-HT1B、5-HT3A、5-HT7受体和 5-羟色胺转运体抑制剂,Ki值分别为 15、33、3.7、19 和 1.6 nM。它作为抗抑郁药,用于治疗重度抑郁症。 | |||
TMIH-0605 |
Vortioxetine-d8 2HBr
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Vortioxetine-d8 2HBr 是 Vortioxetine 2HBr 的氘代化合物。Vortioxetine 2HBr 的 CAS 号为 508233-74-7。Vortioxetine 是5-HT1A、5-HT1B、5-HT3A、5-HT7受体和 5-羟色胺转运体抑制剂,Ki值分别为 15、33、3.7、19 和 1.6 nM。它作为抗抑郁药,用于治疗重度抑郁症。 | |||
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
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Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... |