Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T84455 |
17(R)-Resolvin D1 methyl ester
Aspirin-triggered-Resolvin D1 methyl ester |
Others | Others |
17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that equivalently inhibits human polymorphonuclear leukocyte migration across the endothelium (EC50= ~30 nM), a precursor to acute inflammation. Unlike RvD1, it resists rapid degradation by eicosanoid oxidoreductases. In a mouse peritonitis model, 17(R)-RvD1 dose-dependently reduces leukocyte infiltration, achieving up to a 35% decrease with a 100 ng dose. Additionally, its methyl ester derivative, designed to enhance its phar... |