Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37360 |
6-O-desmethyl Donepezil
|
Others | Others |
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil . It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6. It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 μM in HEK293 cells expressing hERG). |