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Search Results for " 5t4 "

Targets Recommended: ADC Cytotoxin

3

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12081	MMAF-OMe Monomethyl auristatin F methyl ester	ADC Cytotoxin	Antibody-drug Conjugate/ADC Related
	MMAF-OMe (Monomethyl auristatin F methyl ester) 是一种抗微管蛋白剂，能够抑制 MDAMB435/5T4，MDAMB361DYT2，MDAMB468 和 Raji (5T4-) 这四种肿瘤细胞，IC50值分别为 0.056 nM，0.166 nM，0.183 nM 和 0.449 nM。它也是ADC 细胞毒素。
T74880	Cys-McMMAF	Others	Others
	Cys-McMMAF 是 AlMcMMAF 释放的有效载荷，AlMcMMAF 是一种抗 5T4 的人源化 A1 抗体，通过马来酰咪唑丙基连接物偶联到微管破坏 MMAF 。Cys-McMMAF 对两种肿瘤小鼠模型(H1975 和 MDA-MB-361-DYT2 模型) 均有抑癌效果。
T83121	Anatumomab mafenatox ABR-214936
	Anatumomab mafenatox (ABR-214936)是一种73 KDa的重组蛋白，针对广泛表达于恶性肿瘤中的肿瘤相关抗原5T4。该分子构建于修饰后的SEA和小鼠Fab片段之间。Anatumomab mafenatox的主要副作用包括发烧、低血压、疼痛、恶心和嗜睡。

化合物

Cat.No: T12081

Synonym: Monomethyl auristatin F methyl ester

Target: ADC Cytotoxin

Cat.No: T74880

Target: Others

Anatumomab mafenatox

Cat.No: T83121

Synonym: ABR-214936

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05033	5T4/TPBG Protein, Human, Recombinant (aa 60-345, His) 5T4AG,trophoblast glycoprotein,WAIF1,M6P1,5T4	Human	HEK293 Cells
	Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Human, Recombinant (aa 60-345, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.1 kDa and the accession number is Q13641.
TMPJ-00269	5T4/TPBG Protein, Human, Recombinant (mFc) TPBG,5T4 Protein,M6P1 Protein,5T4AG Protei...	Human	HEK293 Cells
	5T4/TPBG Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 80-110 KDa and the accession number is Q13641.
TMPJ-01153	5T4/TPBG Protein, Cynomolgus, Recombinant (His) TPBG,5T4,M6P1,WAIF1,5T4AG	Cynomolgus	HEK293 Cells
	5T4/TPBG Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-80 KDa and the accession number is Q4R8Y9.
TMPK-00270	TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled WAIF1,TPBG,5T4AG,5T4,M6P1	Human	HEK293 Cells
	The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs. TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.2 kDa and the accession numb...
TMPJ-00268	5T4/TPBG Protein, Human, Recombinant (Avi & His), Biotinylated 5T4,M6P1,WAIF1,5T4AG,TPBG	Human	HEK293 Cells
	5T4/TPBG Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 60-90 KDa and the accession number is Q13641.
TMPK-00271	TPBG/5T4 Protein, Human, Recombinant (His & Avi) M6P1,WAIF1,5T4,TPBG,5T4AG	Human	HEK293 Cells
	The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs. TPBG/5T4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is Q13641-1...
TMPY-06214	5T4/TPBG Protein, Mouse, Recombinant (hFc) trophoblast glycoprotein,AW495680,5T4,WAIF1	Mouse	HEK293 Cells
	Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5 kDa and the accession number is Q9Z0L0.
TMPH-02437	5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc) TPBG,WAIF1,Wnt-activated inhibitory factor 1,Trophoblast gly...	Cynomolgus	HEK293 Cells
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 39.9 kDa and the accession number is Q4R8Y9.
TMPY-06191	5T4/TPBG Protein, Mouse, Recombinant (His) trophoblast glycoprotein,WAIF1,5T4,AW495680	Mouse	HEK293 Cells
	Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is Q9Z0L0.
TMPH-03392	5T4/TPBG Protein, Rat, Recombinant (His & SUMO) Wnt-activated inhibitory factor 1,Trophoblast glycoprotein,T...	Rat	E. coli
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 51.8 kDa and the accession number is Q5PQV5.
TMPY-06317	5T4/TPBG Protein, Human, Recombinant (aa 1-355, His) trophoblast glycoprotein,WAIF1,5T4AG,M6P1,5T4	Human	HEK293 Cells
	Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Human, Recombinant (aa 1-355, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.15 kDa and the accession number is NP_006661.1.
TMPH-02436	5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) TPBG,Trophoblast glycoprotein,Wnt-activated inhibitory facto...	Cynomolgus	E. coli
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.9 kDa and the accession number is Q4R8Y9.

重组蛋白

5T4/TPBG Protein, Human, Recombinant (aa 60-345, His)

Cat.No: TMPY-05033

Species: Human

Expression System: HEK293 Cells

5T4/TPBG Protein, Human, Recombinant (mFc)

Cat.No: TMPJ-00269

Species: Human

Expression System: HEK293 Cells

5T4/TPBG Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-01153

Species: Cynomolgus

Expression System: HEK293 Cells

TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled

Cat.No: TMPK-00270

Species: Human

Expression System: HEK293 Cells

5T4/TPBG Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00268

Species: Human

Expression System: HEK293 Cells

TPBG/5T4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00271

Species: Human

Expression System: HEK293 Cells

5T4/TPBG Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-06214

Species: Mouse

Expression System: HEK293 Cells

5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc)

Cat.No: TMPH-02437

Species: Cynomolgus

Expression System: HEK293 Cells

5T4/TPBG Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06191

Species: Mouse

Expression System: HEK293 Cells

5T4/TPBG Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03392

Species: Rat

Expression System: E. coli

5T4/TPBG Protein, Human, Recombinant (aa 1-355, His)

Cat.No: TMPY-06317

Species: Human

Expression System: HEK293 Cells

5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-02436

Species: Cynomolgus

Expression System: E. coli

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