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抑制剂 & 化合物

天然产物

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T35708	N-acetyl-5-Aminosalicylic Acid	Others	Others
	N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-γ binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 μM) scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by ...
T1544	Olsalazine disodium Dipentum,奥沙拉秦钠,Olsalazine Sodium	Others; COX; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Others
	Olsalazine disodium (Dipentum) 是抗炎化合物，可作用于溃疡性结肠炎和炎症性肠病。
T4615	Balsalazide sodium hydrate 巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium	STAT; Interleukin	Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Balsalazide sodium hydrate (Balsalazide disodium) 可通过调节IL-6/STAT3通路起抑癌作用，可用于治疗炎症性肠病。
T37026	Mesalamine impurity P	Others	Others
	Mesalamine impurity P is an impurity of Mesalamine . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1]. [1]. Kyle Dammann, et al.PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation.Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.
T36660	Olsalazine-13C6 Olsalazine-13C6	Others	Others
	Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ...

化合物

N-acetyl-5-Aminosalicylic Acid

Synonym: Dipentum,奥沙拉秦钠,Olsalazine Sodium

Target: Others, COX, Antibacterial, Antibiotic

Balsalazide sodium hydrate

Cat.No: T4615

Synonym: 巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium

Target: STAT, Interleukin

Mesalamine impurity P

Synonym: Olsalazine-13C6

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0646	5-Aminosalicylic Acid Mesalazine,5-ASA,5-氨基水杨酸,Mesalamine	NF-κB; Lipoxygenase; COX; Glutathione Peroxidase; Endogenous Metabolite; PAK; PPAR	Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	5-Aminosalicylic Acid (5-ASA) 是一种特异性的PPARγ激动剂，还抑制 p21-激活激酶1(PAK1) 和NF-κB，具有抗炎活性。

天然产物

5-Aminosalicylic Acid

Cat.No: T0646

Synonym: Mesalazine,5-ASA,5-氨基水杨酸,Mesalamine

Target: NF-κB, Lipoxygenase, COX, Glutathione Peroxidase, Endogenous Metabolite, PAK, PPAR

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0229	Mesalamine-d3
	Mesalamine-d3 是 Mesalamine 的氘代化合物。Mesalamine 的 CAS 号为 89-57-6。5-Aminosalicylic Acid 是一种特异性的PPARγ激动剂，还抑制 p21-激活激酶1 (PAK1) 和NF-κB，具有抗炎活性。