Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T84963 |
5α-Androstan-3β-ol
NSC 50887 |
Others | Others |
5α-Androstan-3β-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 µM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 µM. It selectively inhibits the hydroxylase activities of 16α- and 6β-hydroxylase over 16β- or 7α-hydroxylase, with IC50 values of 70 and 110 µM, compared to >150 µM for the latter enzymes, indicating a specificity in its enzyme inhibition profil... | |||
T73779 |
5β-Androstan-3β-ol-17-one
|
Others | Others |
5β-Androstan-3β-ol-17-one(3β-Etiocholanolone;5β-Epiandrosterone),为5β还原型类固醇,主要是脱氢表雄酮(DHEA)的关键代谢物之一。在C57BL/KsJ基因型糖尿病(db/db)小鼠中,该化合物显示出显著的降糖效果,并且具有对神经元的抑制活性。 |