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Search Results for " 3clpro "

Targets Recommended: Antiviral SARS-CoV

65

抑制剂 & 化合物

3

天然产物

1

化合物库

22

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name
L1710	抗COVID-19化合物库		1133 compounds
	1133 种对SARS-CoV-2有抑制作用或潜在抑制作用的化合物集合，可用于高通量和高内涵筛选；

化合物库

抗COVID-19化合物库

Cat.No: L1710

Compounds: 1133

Cat. No.	Product Name	Target	Signaling Pathways
T77652	SARS-CoV-2 3CLpro-IN-20	Antiviral; SARS-CoV	Immunology/Inflammation; Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-20 是一种共价的 SARS-CoV-2 3CLpro 抑制剂(IC50s: 0.43 μM，)。SARS-CoV-2 3CLpro-IN-20 具有潜在的抗病毒活性。
T79659	SARS-CoV-2 3CLpro-IN-16	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-16为一种共价 SARS-CoV-2 3CLpro 抑制剂，抑制 3CLpro 活性，通过与Cys145形成共价键实现其抑制作用。
T9351	Nirmatrelvir	SARS-CoV	Microbiology/Virology
	Nirmatrelvir (PF-07321332) 是一种 SARS-CoV 3CLPRO 抑制剂，一种胰蛋白酶样蛋白酶抑制剂，具有有效性和口服活性。Nirmatrelvir 对 SARS-CoV-2 病毒有针对性，可研究 COVID-19。
T61774	SARS 3CLpro-IN-1	Others	Others
	SARS 3CLpro-IN-1 (Compound 3b) is a stereo-specific SARS 3CL protease inhibitor that belongs to the octahydroisochromene scaffold. It demonstrates inhibition against the P1 site imidazole, with an IC50 value of 95 μM [1].
T79676	SARS-CoV-2 3CLpro-IN-21	Virus Protease	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-21（Compound D6）作为一种抑制剂，不可逆且共价地作用于SARS-CoV-2 3CLpro，展现出0.03μM的IC50值。该化合物同样对SARS-CoV-1 3CLpro具有抑制效果，其IC50为0.12 μM。
T72370	SARS-CoV-2 3CLpro-IN-6	Others	Others
	SARS-CoV-2 3CLpro-IN-6 是 SARS-CoV-2 3CL 蛋白酶的可逆共价抑制剂。SARS-CoV-2 3CLpro-IN-6 对 SARS-CoV-2 3CLpro 具有强效抑制活性，IC50值为 4.9 μM。SARS-CoV-2 3CLpro-IN-6 可用于 COVID-19 的研究。
T72371	SARS-CoV-2 3CLpro-IN-7	Others	Others
	SARS-CoV-2 3CLpro-IN-7 是一种可逆的共价SARS-CoV-2 3CL 蛋白酶抑制剂，IC50值为 1.4 µM。
T62734	SARS-CoV-2 3CLpro-IN-4	Others	Others
	SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a multifunctional inhibitor of SARS CoV-2 3CLpro, exhibiting antiviral, antibacterial, and antifungal activities.
T79660	SARS-CoV-2 3CLpro-IN-17	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-17 (Compound 3h)为选择性SARS-CoV-2 3CLpro抑制剂，具有0.322μM的IC50s值。
T79462	SARS-CoV-2 3CLpro-IN-14	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-14（compound 11j）为口服活性SARS-CoV-2 3CLpro抑制剂，于Vero E6细胞中对SARS-CoV-2展现出高效抗活性（EC50=0.18 μM），且具备低细胞毒性（CC50>50 μM）。
T63385	SARS-CoV-2 3CLpro-IN-2	Others	Others
	SARS-CoV-2 3CLpro-IN-2 是 3CL 蛋白酶对有效抑制剂，对SARS-CoV-2疾病表现出研究潜力。
T79376	SARS-CoV-2 3CLpro-IN-19	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-19 (Compound C5a)为非共价、非肽类SARS-CoV-2 3CLpro抑制剂，具IC50s值为0.7μM。该化合物对Omicron亚变体（包括BA.5、BQ.1.1及XBB.1.5）在人细胞内的感染显示出具有广谱抗病毒活性，其EC50值介于30-69 nM。
T72312	SARS-CoV-2 3CLpro-IN-10	Others	Others
	SARS-CoV-2 3CLpro-IN-10(5d)为一种有效的抗 SARS-CoV-2 3CL 蛋白酶抑制剂，其IC50值仅为190 nM，同时对SARS-CoV-1的IC50值为790 nM，对MERS-CoV的IC50值则为70 nM，显示出广谱的抗病毒活性。
T63679	SARS-CoV-2 3CLpro-IN-3	Others	Others
	SARS-CoV-2 3CLpro-IN-3 是 SARS CoV-2 3CLpro 抑制剂，表现出抗病毒（antiviral）、抗细菌（antibacterial）、抗真菌（antifungal）效果。
T72364	SARS-CoV-2 3CLpro-IN-5	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-5 是一种针对 3C样蛋白酶3CLpro 的共价抑制剂，其抑制活性的 IC50 为 3.8 nM。该化合物的口服生物利用度（BA）为 9.0%，可用于 COVID-19 研究。
T79661	SARS-CoV-2 3CLpro-IN-18	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-18（Compound 3C）为一种共价SARS-CoV-2 3CLpro抑制剂，具有0.478 μM的IC50值。在Vero E6细胞中对SARS-CoV-2展现出2.499 μM的EC50抑制活性，并显示出较低的细胞毒性（CC50> 200 μM）。
T80657	SARS-CoV-2 3CLpro-IN-15	Virus Protease	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-15（compound a）为β-硝基苯乙烯型抑制剂，专门针对SARS-CoV-2的3CL蛋白酶（3CLpro）而设计。该化合物能有效抑制病毒的复制转录过程，是研发抗COVID-19候选先导化合物的关键因素。
T63537	SARS-CoV-2 3CLpro-IN-1	Others	Others
	SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This particular enzyme has been recognized as a highly promising target for the development of effective antiviral drugs. Therefore, SARS-CoV-2 3CLpro-IN-1 holds significant potential for advancing research and development in the field of infectious diseases [1].
T74807	SARS-CoV-2 3CLpro-IN-13	Others	Others
	SARS-CoV-2 3CLpro-IN-13是一种针对SARS-CoV-2 3CL蛋白酶抑制剂，表现出有效的抗冠状病毒活性，其IC50值达21 nM。
T72313	SARS-CoV-2 3CLpro-IN-11	Others	Others
	SARS-CoV-2 3CLpro-IN-11(11d)为一种针对SARS-CoV-2 3CL蛋白酶的有效抑制剂，具备IC50值140 nM，并对SARS-CoV-1和MERS-CoV分别展现出IC50值240 nM与70 nM的抑制活性，显示出其广谱的抗病毒能力。
T9458	PF-00835231	SARS-CoV	Microbiology/Virology
	PF-00835231 是一种 CoV-2 半胱氨酸 3C 样蛋白酶抑制剂，对 SARS CoV-2 和 SARS CoV-1 3CLpro 的 IC50 分别为 0.27 nM 和 4 nM。它用于抗 SARS-CoV-2/COVID-19 的研究。
T5188	GC376 sodium	SARS-CoV	Microbiology/Virology
	GC376 sodium 是一种 3C 样蛋白酶 (3CLpro) 抑制剂，IC50 值范围为 0.49~4.35 μM。
T8371	ML188	Virus Protease; SARS-CoV	Microbiology/Virology
	ML188是一种选择性非共价 SARS-CoV3CLpro 抑制剂，具有抗病毒活性，IC50为 1.5 μM。
T9672	GRL-0496	SARS-CoV	Microbiology/Virology
	GRL-0496 是氯吡啶酯衍生物，是有效的 SARS-CoV 3CLpro 抑制剂，IC50为 30 nM。GRL-0496显示出抗 SARS-CoV 病毒活性，EC50为 6.9 μM。
T69535	GRL-0820 SARS-CoV-2-IN-6	SARS-CoV	Microbiology/Virology
	GRL-0820 (SARS-CoV-2-IN-6) 是一种高效的 SARS-CoV-2 3CLpro 抑制剂，可用于研究新型冠状病毒感染。
T4578	Tipranavir PNU-140690	SARS-CoV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Tipranavir 是一种蛋白酶抑制剂，对1种以上蛋白酶抑制剂耐药的HIV-1具有抑制作用。Tipranavir 可有效抑制 HIV-1 蛋白酶酶活性和二聚化，对抗多种蛋白酶抑制剂(PI)的HIV-1分离株具有有效的活性（IC50 为 66-410 nM）。Tipranavir 对SARS-CoV-2 3CLpro 活性有抑制作用。
T4474	Asunaprevir BMS-650032,阿那匹韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Asunaprevir (BMS-650032) 是一种有口服活性的 HCV NS3 蛋白酶抑制剂，IC50值为 0.2 nM-3.5 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T4686	Simeprevir TMC435,西咪匹韦,TMC-435350,Olysio	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Simeprevir (TMC435) 是一种有效的 HCV NS3/4A 蛋白酶抑制剂，抑制 HCV 复制，EC50 为 7.8 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T60095	CCF0058981	SARS-CoV	Microbiology/Virology
	CCF0058981 (CCF981) 是3-氯苯基类似物，是一种非共价 SARS-CoV-2 3CLpro(SC2)抑制剂，IC50为 68 nM。CCF0058981 抑制 SC1 (SARS-CoV-1 3CLpro)，IC50为 19 nM。CCF0058981 具有抗病毒功效，具有用于 COVID-19 研究的潜力。
T5126	Glecaprevir ABT-493	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Glecaprevir (ABT-493) 是一种新型的 HCV NS3/4A 蛋白酶抑制剂，其 IC50值在 3.5 和 11.3 nM 之间。它也是 SARS-CoV 3CLpro 的抑制剂，IC50为 4.09 μM。
T6388	Amprenavir 141W94,安普那韦,Prozei,KVX-478,VX-478,安瑞那韦	SARS-CoV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Amprenavir (KVX-478) 是一种 HIV 蛋白酶抑制剂，Ki 为0.6 nM。它也是 SARS-CoV 3CLpro 抑制剂，IC50为 1.09 μM。
T7903	Saquinavir Ro 31-8959,沙奎那韦	SARS-CoV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂，可研究逆转录病毒。它也是 SARS-CoV 3CLpro 抑制剂，IC50为 1.36 μM。
T6190	Telaprevir VX-950,LY-570310,Incivek,MP-424,特拉匹韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Telaprevir (Incivek) 是一种选择性可逆的HCV NS3-4A 蛋白酶抑制剂，作用于基因 1型 (H 株) NS3 蛋白酶结构域和 NS4A 辅因子肽，Ki 为 7 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T0100L	Atazanavir Zrivada,Reyataz,Latazanavir,阿扎那韦,BMS-232632	P450; SARS-CoV; HIV Protease; P-gp	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Atazanavir (BMS-232632) 是一种高选择性的HIV-1蛋白酶抑制剂，可研究艾滋病毒感染。它也是SARS-CoV 3CLpro 的抑制剂，IC50为 3.49 μM。它是CYP3A4的底物和抑制剂，也是P-糖蛋白的抑制剂和诱导剂。
T5863	Indinavir sulfate L735524 sulfate,MK-639 sulfate,硫酸茚地那韦	SARS-CoV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Indinavir sulfate (L735524 sulfate) 是一种 HIV 蛋白酶抑制剂。它抑制 HIV-1 蛋白酶，IC50 值为 0.41 nM，Ki 值为 0.24 nM。它也是SARS-CoV 3CLpro 抑制剂，IC50为 1.71 μM。
T22394	Paritaprevir ABT450,ABT-450,帕利普韦,Veruprevir	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Paritaprevir (ABT450) 是一种非结构蛋白 3/4A 蛋白酶抑制剂，对 HCV 1a 和 HCV 1b 的 EC50 值分别为 1 和 0.21 nM。它也是SARS-CoV 3CLpro 的抑制剂，IC50为 1.31 μM。
T6025	Danoprevir R7227,丹诺普韦,ITMN-191,RG7227,RO5190591	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Danoprevir (RG7227) 是具有口服活性的NS3/4A 蛋白酶抑制剂，IC50值为 0.29 nM。它抑制 HCV 基因型 1a, 1b, 4, 5, 6 (IC50s=0.2-0.4 nM) 和 2b, 3a (IC50s=1.6, 3.5 nM)。它也是SARS-CoV 3CLpro 的抑制剂，IC50为 0.05 μM。
T1525	Ritonavir RTV,利托那韦,Abbott 84538,A 84538,ABT 538	Apoptosis; SARS-CoV; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Ritonavir (ABT 538) 是一种 HIV 蛋白酶抑制剂，可研究 HIV 感染和 AIDS 。它也是 SARS-CoV 3CLpro 的抑制剂，IC50为 1.61 μM。
T0100	Atazanavir sulfate 阿扎那韦硫酸盐,BMS-232632,BMS-232632 sulfate,硫酸阿扎那韦	P450; SARS-CoV; HIV Protease; P-gp	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Atazanavir sulfate (BMS-232632 sulfate) 是一种氮杂肽和 HIV 蛋白酶抑制剂，与其他抗 HIV 药物联合用于治疗 HIV 感染和艾滋病。它也是SARS-CoV 3CLpro 抑制剂，IC50为 3.49 μM。
T4988	Boceprevir SCH 503034,EBP 520,波普瑞韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Boceprevir (SCH 503034) 是一种口服有效的选择性 HCV NS3 蛋白酶抑制剂。在酶试验中的 Ki 为 14 nM，在基于细胞的复制子试验中 EC90 为 350 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T1623	Lopinavir ABT-378,洛匹那韦	SARS-CoV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Lopinavir (ABT-378) 是一种选择性肽模拟 HIV-1 蛋白酶的高效抑制剂。它通过阻止 HIV-1 的成熟而起作用，从而阻断其感染性。它也是 SARS-CoV 3CLpro 的抑制剂。
T4547	Grazoprevir MK-5172	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Grazoprevir (MK-5172) 是一种丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂，具有跨基因型和耐药变体的广泛活性，对 gt1b、gt1a、gt2a、gt2b 和 gt3a 的Ki 分别为 0.01 nM、0.01 nM、0.08 nM、0.15 nM 和 0.90 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T3334	Velpatasvir GS-5816,维帕他韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Velpatasvir (GS-5816) 是一种的 HCV NS5A 抑制剂。它也是 SARS-CoV 3CLpro 的抑制剂，IC50为 2.16 μM。
T9716	Ensitrelvir S-217622	SARS-CoV	Microbiology/Virology
	Ensitrelvir (S-217622) 是首个口服有效的、非共价的、非肽的SARS-CoV-2 3CL 蛋白酶抑制剂，IC50为13 nM。
T14968	Cinanserin hydrochloride SQ 10643	Influenza Virus; 5-HT Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Cinanserin hydrochloride (SQ 10643) 是一种高亲和力拮抗剂，对 5-HT2 受体的Ki 值为 41 nM。它也是严重急性呼吸综合征冠状病毒的 3C 样蛋白酶抑制剂。
T6738	Z-FA-FMK	SARS-CoV; Cysteine Protease	Microbiology/Virology; Proteases/Proteasome
	Z-FA-FMK 是一种广谱的卤代甲基酮抑制剂，可抑制冠状病毒蛋白酶3CL，Ki 为 25.7 μM。它可以不可逆地抑制半胱氨酸蛋白酶，也可以抑制效应半胱天冬酶。
T68674	Vincapusine	Others	Others
	Vincapusine is a natural inhibitor of 3C-like protease (3CLpro), targeting SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro.
T63483	INSCoV-614(1B)	Others	Others
	INSCoV-614(1B) 是一种有效的 Mpro(3CLpro) 抑制剂。蛋白酶 (PLpro 和 3CLpro) 与病毒的转录和复制有关。INSCoV-614(1B) 对 SARS-CoV-2 感染表现出研究潜力。
T9686	YH-53	Others	Others
	YH-53 是一种有效的3CLpro 抑制剂，对 SARS-CoV-1 3CLpro 和 SARS-CoV-2 3CLpro 的Ki 值分别为 6.3 nM、34.7 nM。YH-53 能够有效阻断 SARS-CoV-2 复制。YH-53 是一种具有独特苯并噻唑基酮的拟肽化合物。YH-53 具有用于研究新冠病毒的潜力。
T63462	INSCoV-601I(1)	Others	Others
	INSCoV-601I(1) 是一种有效的 Mpro(3CLpro) 抑制剂。蛋白酶 (PLpro 和 3CLpro) 与病毒的转录和复制有关。INSCoV-600I(1) 对 SARS-CoV-2 感染表现出研究潜力。

化合物

SARS-CoV-2 3CLpro-IN-20

Cat.No: T77652

Target: Antiviral, SARS-CoV

SARS-CoV-2 3CLpro-IN-16

Cat.No: T79659

Target: SARS-CoV

Cat.No: T9351

Target: SARS-CoV

SARS 3CLpro-IN-1

Cat.No: T61774

Target: Others

SARS-CoV-2 3CLpro-IN-21

Cat.No: T79676

Target: Virus Protease

SARS-CoV-2 3CLpro-IN-6

Cat.No: T72370

Target: Others

SARS-CoV-2 3CLpro-IN-7

Cat.No: T72371

Target: Others

SARS-CoV-2 3CLpro-IN-4

Cat.No: T62734

Target: Others

SARS-CoV-2 3CLpro-IN-17

Cat.No: T79660

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-14

Cat.No: T79462

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-2

Cat.No: T63385

Target: Others

SARS-CoV-2 3CLpro-IN-19

Cat.No: T79376

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-10

Cat.No: T72312

Target: Others

SARS-CoV-2 3CLpro-IN-3

Cat.No: T63679

Target: Others

SARS-CoV-2 3CLpro-IN-5

Cat.No: T72364

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-18

Cat.No: T79661

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-15

Cat.No: T80657

Target: Virus Protease

SARS-CoV-2 3CLpro-IN-1

Cat.No: T63537

Target: Others

SARS-CoV-2 3CLpro-IN-13

Cat.No: T74807

Target: Others

SARS-CoV-2 3CLpro-IN-11

Cat.No: T72313

Target: Others

Cat.No: T9458

Target: SARS-CoV

Cat.No: T5188

Target: SARS-CoV

Cat.No: T8371

Target: Virus Protease, SARS-CoV

Cat.No: T9672

Target: SARS-CoV

Cat.No: T69535

Synonym: SARS-CoV-2-IN-6

Target: SARS-CoV

Cat.No: T4578

Synonym: PNU-140690

Target: SARS-CoV, HIV Protease

Cat.No: T4474

Synonym: BMS-650032,阿那匹韦

Target: HCV Protease, SARS-CoV

Cat.No: T4686

Synonym: TMC435,西咪匹韦,TMC-435350,Olysio

Target: HCV Protease, SARS-CoV

Cat.No: T60095

Target: SARS-CoV

Cat.No: T5126

Synonym: ABT-493

Target: HCV Protease, SARS-CoV

Cat.No: T6388

Synonym: 141W94,安普那韦,Prozei,KVX-478,VX-478,安瑞那韦

Target: SARS-CoV, HIV Protease

Cat.No: T7903

Synonym: Ro 31-8959,沙奎那韦

Target: SARS-CoV, HIV Protease

Cat.No: T6190

Synonym: VX-950,LY-570310,Incivek,MP-424,特拉匹韦

Target: HCV Protease, SARS-CoV

Cat.No: T0100L

Synonym: Zrivada,Reyataz,Latazanavir,阿扎那韦,BMS-232632

Target: P450, SARS-CoV, HIV Protease, P-gp

Indinavir sulfate

Cat.No: T5863

Synonym: L735524 sulfate,MK-639 sulfate,硫酸茚地那韦

Target: SARS-CoV, HIV Protease

Cat.No: T22394

Synonym: ABT450,ABT-450,帕利普韦,Veruprevir

Target: HCV Protease

Cat.No: T6025

Synonym: R7227,丹诺普韦,ITMN-191,RG7227,RO5190591

Target: HCV Protease, SARS-CoV

Cat.No: T1525

Synonym: RTV,利托那韦,Abbott 84538,A 84538,ABT 538

Target: Apoptosis, SARS-CoV, HIV Protease

Atazanavir sulfate

Cat.No: T0100

Synonym: 阿扎那韦硫酸盐,BMS-232632,BMS-232632 sulfate,硫酸阿扎那韦

Target: P450, SARS-CoV, HIV Protease, P-gp

Cat.No: T4988

Synonym: SCH 503034,EBP 520,波普瑞韦

Target: HCV Protease, SARS-CoV

Cat.No: T1623

Synonym: ABT-378,洛匹那韦

Target: SARS-CoV, HIV Protease

Cat.No: T4547

Synonym: MK-5172

Target: HCV Protease, SARS-CoV

Cat.No: T3334

Synonym: GS-5816,维帕他韦

Target: HCV Protease, SARS-CoV

Cat.No: T9716

Synonym: S-217622

Target: SARS-CoV

Cinanserin hydrochloride

Cat.No: T14968

Synonym: SQ 10643

Target: Influenza Virus, 5-HT Receptor

Cat.No: T6738

Target: SARS-CoV, Cysteine Protease

Cat.No: T68674

Target: Others

Cat.No: T63483

Target: Others

Cat.No: T9686

Target: Others

Cat.No: T63462

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3921	Punicalagin 安石榴甙,安石榴苷	SARS-CoV; HBV	Microbiology/Virology
	Punicalagin 是一种在石榴中发现的主要鞣花单宁，是可逆且非竞争性的 3CLpro 抑制剂。Punicalagin 具有抗氧化、抗炎和抗肿瘤活性。
TN2302	Viscidulin III Ganhuangenin	Glucosidase	Metabolism
	Viscidulin III (Ganhuangenin) 存在于黄芩中，可作为α-葡萄糖苷酶抑制剂。
T80010	(25S)-Antcin B	SARS-CoV	Microbiology/Virology
	Antcin-B是3CLPro的高亲和力有效抑制剂，可用于SARS-CoV-2的研究。

天然产物

Cat.No: T3921

Synonym: 安石榴甙,安石榴苷

Target: SARS-CoV, HBV

Cat.No: TN2302

Synonym: Ganhuangenin

Target: Glucosidase

Cat.No: T80010

Target: SARS-CoV

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01449	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant M Proteinase,3C-like Proteinase,3CL Protei...	SARS-CoV-2	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant is expressed in E. coli expression system. The predicted molec...
TMPY-05752	SARS-CoV-2 3CLpro/3C-like protease Protein (His)	SARS-CoV-2	Baculovirus Insect Cells
	3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication and Coronavirus virion production, such as an RNA-dependent RNA polymerase, a helicase, ribonucleases and 3CLpro itself, from two types of polyproteins (pp1a and pp1ab). SARS-CoV 3CLpro exists as a homodimer and each protomer has an active site. SARS-CoV-2 3CLpro/3C-like protease P...
TMPK-01342	3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant Mpro,3CL-Mpro,3CL Protease,M Proteinase	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.8kDa and the accession number is YP_009725301.1.
TMPK-01347	3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant 3CL-Mpro,3CL Protease,M Proteinase,Mpro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.4kDa and the accession number is YP_009725301.1.
TMPK-01343	3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant 3CL-Mpro,M Proteinase,Mpro,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPY-05727	SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi)	SARS-CoV-2	E. coli
	3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication and Coronavirus virion production, such as an RNA-dependent RNA polymerase, a helicase, ribonucleases and 3CLpro itself, from two types of polyproteins (pp1a and pp1ab). SARS-CoV 3CLpro exists as a homodimer and each protomer has an active site. SARS-CoV-2 3CLpro/3C-like protease P...
TMPK-01335	3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant M Proteinase,Mpro,3CL Protease,3CL-Mpro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.80 kDa and the accession number is YP_009725301.1.
TMPK-01339	3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant 3CL-Mpro,M Proteinase,3CL Protease,Mpro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.78 kDa and the accession number is YP_009725301.1.
TMPK-01344	3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant M Proteinase,Mpro,3CL-Mpro,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.5kDa and the accession number is YP_009725301.1.
TMPJ-01448	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) M Proteinase,3CL Proteinase	2019-nCoV	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) is expressed in E. coli expression system with N-6xHis t...
TMPK-01346	3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant 3CL-Mpro,Mpro,M Proteinase,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8kDa and the accession number is YP_009725301.1.
TMPK-01340	3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant 3CL-Mpro,3CL Protease,M Proteinase,Mpro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.72 kDa and the accession number is YP_009725301.1.
TMPK-01337	3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant Mpro,3CL-Mpro,3CL Protease,M Proteinase	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.79 kDa and the accession number is YP_009725301.1.
TMPK-01338	3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant M Proteinase,3CL-Mpro,Mpro,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.82 kDa and the accession number is YP_009725301.1.
TMPK-01341	3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant 3CL Protease,3CL-Mpro,Mpro,M Proteinase	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPK-01348	3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) COVID-19,3CL Protease,M Proteinase,3CL Pro...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPK-01336	3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant 3CL-Mpro,3CL Protease,M Proteinase,Mpro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.80 kDa and the accession number is YP_009725301.1.
TMPK-01345	3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant 3CL-Mpro,Mpro,M Proteinase,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.5 kDa and the accession number is YP_009725301.1.
TMPK-01384	SARS PLpro/papain-like protease Protein (His) Papain-like Protease,PL-PRO,Replicase polyprotein 1a,pp1a,PL...	SARS	E. coli
	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS PLpro/papain-like protease Protein (...
TMPK-01352	SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) Plpro,PL2-PRO,pp1a,nsp1,Replicase polyprotein 1a,Papain-like...	SARS	E. coli
	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS-CoV-2 PLpro/papain-like protease Pro...
TMPJ-01428	SARS-CoV-2 NSP8 Protein (His) SARS-CoV 2 nsp8	SARS-CoV-2	E. coli
	Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.Nsp8 was shown to have RNA-dependen...
TMPJ-01431	SARS-CoV-2 Papain-Like Protease Protein PLpro,PL-PRO,pp1a,Replicase polyprotein 1a,Papain-like Prote...	SARS-CoV-2	E. coli
	Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) sect...

重组蛋白

3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant

Cat.No: TMPJ-01449

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 3CLpro/3C-like protease Protein (His)

Cat.No: TMPY-05752

Species: SARS-CoV-2

Expression System: Baculovirus Insect Cells

3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant

Cat.No: TMPK-01342

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant

Cat.No: TMPK-01347

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant

Cat.No: TMPK-01343

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi)

Cat.No: TMPY-05727

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant

Cat.No: TMPK-01335

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant

Cat.No: TMPK-01339

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant

Cat.No: TMPK-01344

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His)

Cat.No: TMPJ-01448

Species: 2019-nCoV

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant

Cat.No: TMPK-01346

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant

Cat.No: TMPK-01340

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant

Cat.No: TMPK-01337

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant

Cat.No: TMPK-01338

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant

Cat.No: TMPK-01341

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306)

Cat.No: TMPK-01348

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant

Cat.No: TMPK-01336

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant

Cat.No: TMPK-01345

Species: SARS-CoV-2

Expression System: E. coli

SARS PLpro/papain-like protease Protein (His)

Cat.No: TMPK-01384

Species: SARS

Expression System: E. coli

SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)

Cat.No: TMPK-01352

Species: SARS

Expression System: E. coli

SARS-CoV-2 NSP8 Protein (His)

Cat.No: TMPJ-01428

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 Papain-Like Protease Protein

Cat.No: TMPJ-01431

Species: SARS-CoV-2

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0394	Nirmatrelvir-d9
	Nirmatrelvir-d9 是 Nirmatrelvir 的氘代化合物。Nirmatrelvir 的 CAS 号为 2628280-40-8。PF-07321332 是一种有效的口服活性SARS-CoV 3CLPRO抑制剂，对 SARS-CoV-2 病毒有针对性，可研究 COVID-19。它是一种胰蛋白酶样蛋白酶抑制剂，可抑制气道上皮钠通道功能。
TMID-0082	Lopinavir-d8
	Lopinavir-d8 是 Lopinavir 的氘代化合物。Lopinavir 的 CAS 号为 192725-17-0。Lopinavir 是一种选择性肽模拟 HIV-1 蛋白酶的高效抑制剂。它通过阻止 HIV-1 的成熟而起作用，从而阻断其感染性。它也是SARS-CoV 3CLpro的抑制剂。
TMIJ-0076	Ritonavir-13C-d3
	Ritonavir-13C-d3 是 Ritonavir 的 13C 和氘代化合物。Ritonavir 的 CAS 号为 155213-67-5。Ritonavir 是一种 HIV 蛋白酶抑制剂，可研究 HIV 感染和 AIDS 。它也是SARS-CoV 3CLpro的抑制剂，IC50为 1.61 μM。

同位素标记化合物

Nirmatrelvir-d9

Cat.No: TMIH-0394

Cat.No: TMID-0082

Ritonavir-13C-d3

Cat.No: TMIJ-0076

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