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Search Results for " 26s "
Targets Recommended: Proteasome

15

抑制剂 & 化合物

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化合物库

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重组蛋白

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Cat. No. Product Name
L8600 泛素化化合物库

210 compounds
210 种泛素化相关的小分子，用于高通量和高内涵筛选；

化合物库

泛素化化合物库
Cat.No: L8600
Compounds: 210
Cat. No. Product Name Target Signaling Pathways
T7814 Alloxan monohydrate

Proteasome Proteases/Proteasome; Ubiquitination
Alloxan Monohydrate 是一种能够引起糖尿病的致糖尿病药物。它作为蛋白酶体抑制剂，破坏胰腺中能够分泌胰岛素的B 细胞，导致实验动物患糖尿病。
T2154 MG-132

Z-LLL-al,Z-Leu-Leu-Leu-CHO

 Apoptosis; Proteasome; Autophagy Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination
MG-132 (Z-Leu-Leu-Leu-al) 是一种 26S 蛋白酶体抑制剂 (IC50=100 nM)，具有细胞渗透性、可逆性。MG-132 可作为自噬激活剂，可诱导凋亡。
T78353 alpha-2,6-Sialyltransferase (Pd26ST)

Others Others
alpha-2,6-Sialyltransferase (Pd26ST) 能够催化末端和内部半乳糖及N-乙酰半乳糖胺的唾液酸化，形成末端α2,6-唾液酸苷。
T9090 MUN57694

Proteasome Proteases/Proteasome; Ubiquitination
MUN57694 是 26S 蛋白酶体的抑制剂。
T1932 B-AP15

NSC 687852

 Apoptosis; DUB Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
B-AP15 (NSC-687852) 是 26S 蛋白酶体的去泛素化酶 Usp14 和 UCHL5 的选择性抑制剂。 它阻断 26S 蛋白酶体的去泛素化活性。
T36902 RA375

RA375

 Proteasome Proteases/Proteasome; Ubiquitination
RA375 是一种 RPN13（26S 蛋白酶体调节亚基）抑制剂。 RA375 激活 UPR 信号、ROS 产生和细胞凋亡。 RA375 对癌症细胞的活性比 RA190 高 10 倍，这反映了它的硝基环取代基和氯乙酰胺弹头的添加。
T21617 MG-115

Z-LL-Nva-CHO

 Proteasome Proteases/Proteasome; Ubiquitination
MG-115 (Z-LL-Nva-CHO) 是一种有效且可逆的蛋白酶体抑制剂，对20S 和26S 蛋白酶体的 Ki 值分别为 21 nM 和 35 nM。MG-115 特异性抑制蛋白酶体的胰凝乳蛋白酶样活性，诱导 p53 依赖性细胞凋亡。
T60487 DDO-7263

Nrf2 Immunology/Inflammation
DDO-7263 是一种 1,2,4-Oxadiazole 衍生物， 通过与 Rpn6 结合上调 Nrf2，从而阻断 26S 蛋白酶体的组装和随后Nrf2 的泛素化降解。DDO-7263 是一种有效的Nrf2激活剂，能够激活 Nrf2-ARE 信号通路并发挥抗炎活性。
T76038 Ac-Nle-Pro-Nle-Asp-AMC

Ac-Nle-Pro-Nle-Asp-AMC 是26S 蛋白酶体(26Sproteasome)的特异性底物，适用于分析26S 蛋白酶体中caspase样活性。
T37011 Boc-LRR-AMC

Others Others
Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
T37417L Z-LLE-AMC acetate(348086-66-8 Free base)

Z-LLE-AMC acetate(348086-66-8 Free base) 是 26S 蛋白酶体或 20S 蛋白水解核心的半胱天冬酶样谷氨酸后肽水解酶的荧光底物。 Z-LLE-AMC acetate 通常用于实验处理后的细胞裂解液中。
T77939 WBC100

14-D-Valine-TPL

 c-Myc Cell Cycle/Checkpoint
WBC100（14-D-Valine-TPL），一款高效、选择性和具口服活性的c-Myc小分子降解剂，通过针对泛素E3连结酶CHIP介导的26S蛋白酶体途径实现其作用。主要应用于c-Myc过表达肿瘤的研究领域。
T37417 Z-LLE-AMC

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.
T37418 Z-LLL-AMC

Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core. Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLL-AMC is typically used in cell lysates after experimental treatment.
T62080 GSK3494245

Others Others
GSK3494245 (DDD01305143) 是一种有效的、选择性的、口服具有活力的、可在夹在 β4 和 β5 亚基之间的位点结合寄生虫蛋白酶体 (proteasome) 的糜蛋白酶样活性抑制剂，能够作用于 WTL.donovani 蛋白酶体，其 IC50 值为 0.16μM。GSK3494245 表现出良好的生物安全特性。GSK3494245 对人蛋白酶体的糜蛋白酶样活性具有适当的抑制作用 (IC50: 26S=13 μM；富集的 THP-1 提取物 IC50=40 μM)。

化合物

Alloxan monohydrate
Cat.No: T7814
Synonym:
Target: Proteasome
MG-132
Cat.No: T2154
Synonym: Z-LLL-al,Z-Leu-Leu-Leu-CHO
Target: Apoptosis, Proteasome, Autophagy
alpha-2,6-Sialyltransferase (Pd26ST)
Cat.No: T78353
Synonym:
Target: Others
MUN57694
Cat.No: T9090
Synonym:
Target: Proteasome
B-AP15
Cat.No: T1932
Synonym: NSC 687852
Target: Apoptosis, DUB
RA375
Cat.No: T36902
Synonym: RA375
Target: Proteasome
MG-115
Cat.No: T21617
Synonym: Z-LL-Nva-CHO
Target: Proteasome
DDO-7263
Cat.No: T60487
Synonym:
Target: Nrf2
Ac-Nle-Pro-Nle-Asp-AMC
Cat.No: T76038
Synonym:
Target:
Boc-LRR-AMC
Cat.No: T37011
Synonym:
Target: Others
Z-LLE-AMC acetate(348086-66-8 Free base)
Cat.No: T37417L
Synonym:
Target:
WBC100
Cat.No: T77939
Synonym: 14-D-Valine-TPL
Target: c-Myc
Z-LLE-AMC
Cat.No: T37417
Synonym:
Target:
Z-LLL-AMC
Cat.No: T37418
Synonym:
Target:
GSK3494245
Cat.No: T62080
Synonym:
Target: Others
Species：
Human (10)
SARS-CoV-2 (6)
Mouse (3)
HIV-2 (1)
Expression System：
E. coli (10)
Baculovirus Insect Cells (6)
HEK293 Cells (3)
P. pastoris (Yeast) (1)
Tag：
C-His (5)
N-His (5)
N-10xHis, C-Myc (4)
C-6xHis (1)
C-His-Avi (1)
N-10xHis (1)
N-6xHis (1)
N-MBP, C-6xHis (1)
Tag Free (1)
Cat. No. Product Name Species Expression System
TMPH-00849 PSMD14 Protein, Human, Recombinant (His & MBP)

26S proteasome non-ATPase regulatory subunit 14,PSM...

 Human Baculovirus Insect Cells
PSMD14 Protein, Human, Recombinant (His & MBP) is expressed in Baculovirus insect cells with N-MBP and C-6xHis tag. The predicted molecular weight is 79.2 kDa and the accession number is O00487.
TMPJ-00703 Gankyrin Protein, Human, Recombinant

PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulator...

 Human E. coli
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
TMPY-06429 SARS-CoV-2 Spike S1+S2 Protein (P26S, 69-70 deletion & V126A & Y144 deletion & 241-243 deletion & H245Y & S477N & E484K & D614G & P681H & T1027I & D1118H, His)

SARS-CoV-2 Baculovirus Insect Cells
SARS-CoV-2 Spike S1+S2 Protein (P26S, 69-70 deletion & V126A & Y144 deletion & 241-243 deletion & H245Y & S477N & E484K & D614G & P681H & T1027I & D1118H, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 133.72 kDa and the accession number is A0A6G7K2L4.
TMPY-06268 SARS-CoV-2 Spike S1 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y, His & Avi), Biotinylated

SARS-CoV-2 HEK293 Cells
SARS-CoV-2 Spike S1 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 78.28 kDa and the accession number is A0A6G7K2L4.
TMPY-06159 SARS-CoV-2 Spike S1+S2 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y & T1027I & V1176F, His)

SARS-CoV-2 Baculovirus Insect Cells
SARS-CoV-2 Spike S1+S2 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y & T1027I & V1176F, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 134.5 kDa and the accession number is A0A6G7K2L4.
TMPY-06131 SARS-CoV-2 Spike S1+S2 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y & T1027I, His)

SARS-CoV-2 Baculovirus Insect Cells
SARS-CoV-2 Spike S1+S2 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y & T1027I, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 134.4 kDa and the accession number is A0A6G7K2L4.
TMPY-06420 SARS-CoV-2 Spike S1 Protein (P26S & 69-70 deletion & V126A & Y144 deletion & 241-243 deletion & H245Y & S477N & E484K & D614G & P681H, His)

SARS-CoV-2 HEK293 Cells
SARS-CoV-2 Spike S1 Protein (P26S & 69-70 deletion & V126A & Y144 deletion & 241-243 deletion & H245Y & S477N & E484K & D614G & P681H, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 75.77 kDa and the accession number is A0A6G7K2L4.
TMPY-06136 SARS-CoV-2 Spike S1 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y, His)

SARS-CoV-2 HEK293 Cells
SARS-CoV-2 Spike S1 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 76.5 kDa and the accession number is A0A6G7K2L4.
TMPH-02250 TPP2 Protein, Human, Recombinant (His & Myc)

Tripeptidyl-peptidase II,Tripeptidyl aminopeptidase,Tripepti...

 Human Baculovirus Insect Cells
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis.
TMPH-03762 TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc)

Tpp2,Tripeptidyl-peptidase 2,Tripeptidyl aminopeptidase,Trip...

 Mouse E. coli
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 29.5 kDa and the accession number is Q64514.
TMPH-02953 TPP2 Protein, Mouse, Recombinant (His & Myc)

Tripeptidyl aminopeptidase,Tripeptidyl-peptidase 2,Tripeptid...

 Mouse Baculovirus Insect Cells
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. TPP2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 28.3 kDa and the accession number is Q64514.
TMPH-03757 TPP2 Protein, Human, Recombinant (E. coli, His & Myc)

TPP2,Tripeptidyl-peptidase II,Tripeptidyl-peptidase 2,Tripep...

 Human E. coli
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. TPP2 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.8 kDa and the accession number is P29144.
TMPH-02284 USP26 Protein, Human, Recombinant (His)

USP26,Deubiquitinating enzyme 26,Ubiquitin thioesterase 26,U...

 Human E. coli
Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
TMPY-00607 PSMB6 Protein, Mouse, Recombinant (His)

proteasome (prosome, macropain) subunit, β type, 6,Mpnd,Lmp1...

 Mouse E. coli
PSMB6 subunit belongs to the 20S proteasomal subunit family, which plays an importance role in the antigen presentation by MHC class I molecular. Proteasome subunit beta type 6 (PSMB6) is a member of 20S proteasomal subunit family, which forms the proteolytic core of 26S proteasome. PSMB6 knockdown decreased cellular viability under DM treatment. PSMB6 is associated with DM resistance in mosquitoes and that proteasome inhibitors such as MG-132 or bortezomib are suitable for use as a DM synergist...
TMPJ-01013 VCP Protein, Human, Recombinant (His)

TER ATPase,Transitional Endoplasmic Reticulum ATPase,15S Mg(...

 Human E. coli
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin...
TMPH-01522 HIV-2 (subtype A, isolate ROD) Protein Vpx (His)

vpx,Viral protein X,X ORF protein,Protein Vpx

 HIV-2 P. pastoris (Yeast)
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by...
TMPH-02300 RAD23A Protein, Human, Recombinant (His)

UV excision repair protein RAD23 homolog A,RAD23A

 Human E. coli
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucle...
TMPY-03612 PSME1 Protein, Human, Recombinant (His)

proteasome (prosome, macropain) activator subunit 1 (PA28 al...

 Human E. coli
PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit...
TMPY-03614 PSME3 Protein, Human, Recombinant (His)

PA28G,PA28-gamma,HEL-S-283,REG-GAMMA,proteasome (prosome, ma...

 Human E. coli
PSME3, also known as PA28-gamma, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase su...
TMPY-03610 PSME2 Protein, Human, Recombinant (His)

REGβ,proteasome (prosome, macropain) activator subunit 2 (PA...

 Human E. coli
PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit...

重组蛋白

PSMD14 Protein, Human, Recombinant (His & MBP)
Cat.No: TMPH-00849
Species: Human
Expression System: Baculovirus Insect Cells
Gankyrin Protein, Human, Recombinant
Cat.No: TMPJ-00703
Species: Human
Expression System: E. coli
SARS-CoV-2 Spike S1+S2 Protein (P26S, 69-70 deletion & V126A & Y144 deletion & 241-243 deletion & H245Y & S477N & E484K & D614G & P681H & T1027I & D1118H, His)
Cat.No: TMPY-06429
Species: SARS-CoV-2
Expression System: Baculovirus Insect Cells
SARS-CoV-2 Spike S1 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y, His & Avi), Biotinylated
Cat.No: TMPY-06268
Species: SARS-CoV-2
Expression System: HEK293 Cells
SARS-CoV-2 Spike S1+S2 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y & T1027I & V1176F, His)
Cat.No: TMPY-06159
Species: SARS-CoV-2
Expression System: Baculovirus Insect Cells
SARS-CoV-2 Spike S1+S2 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y & T1027I, His)
Cat.No: TMPY-06131
Species: SARS-CoV-2
Expression System: Baculovirus Insect Cells
SARS-CoV-2 Spike S1 Protein (P26S & 69-70 deletion & V126A & Y144 deletion & 241-243 deletion & H245Y & S477N & E484K & D614G & P681H, His)
Cat.No: TMPY-06420
Species: SARS-CoV-2
Expression System: HEK293 Cells
SARS-CoV-2 Spike S1 Protein (L18F & T20N & P26S & D138Y & R190S & K417T & E484K & N501Y & D614G & H655Y, His)
Cat.No: TMPY-06136
Species: SARS-CoV-2
Expression System: HEK293 Cells
TPP2 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-02250
Species: Human
Expression System: Baculovirus Insect Cells
TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc)
Cat.No: TMPH-03762
Species: Mouse
Expression System: E. coli
TPP2 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02953
Species: Mouse
Expression System: Baculovirus Insect Cells
TPP2 Protein, Human, Recombinant (E. coli, His & Myc)
Cat.No: TMPH-03757
Species: Human
Expression System: E. coli
USP26 Protein, Human, Recombinant (His)
Cat.No: TMPH-02284
Species: Human
Expression System: E. coli
PSMB6 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00607
Species: Mouse
Expression System: E. coli
VCP Protein, Human, Recombinant (His)
Cat.No: TMPJ-01013
Species: Human
Expression System: E. coli
HIV-2 (subtype A, isolate ROD) Protein Vpx (His)
Cat.No: TMPH-01522
Species: HIV-2
Expression System: P. pastoris (Yeast)
RAD23A Protein, Human, Recombinant (His)
Cat.No: TMPH-02300
Species: Human
Expression System: E. coli
PSME1 Protein, Human, Recombinant (His)
Cat.No: TMPY-03612
Species: Human
Expression System: E. coli
PSME3 Protein, Human, Recombinant (His)
Cat.No: TMPY-03614
Species: Human
Expression System: E. coli
PSME2 Protein, Human, Recombinant (His)
Cat.No: TMPY-03610
Species: Human
Expression System: E. coli
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