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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37265 |
15(R)-Lipoxin A4
15(R)-Lipoxin A4,AT-Lipoxin A4 |
Others | Others |
Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may... | |||
T37305 |
6(S)-Lipoxin A4
6(S)-Lipoxin A4 |
Others | Others |
The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene. Lipoxin A4 (LXA4) was first described as a metabolite of 15-HpETE and/or 15-HETE when added in vitro to isolated human leukocytes. The material obtained in this manner consists of at least four distinct isomers: 5(S), 6(S); 5(S), 6(R); and the 11-trans and 11-cis isomers of each of these. 6(S)-LXA4 is one of the original four metabolites first identified by Serhan, Nicolaou, and Samuelsson. It was considered to b... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36051 |
Lipoxin A4
LXA4 |
Endogenous Metabolite; Interleukin | Immunology/Inflammation; Metabolism |
Lipoxin A4 (LXA4) 是一种内源性脂氧合酶衍生的类花生酸介质,具有抗炎作用。Lipoxin A4 通过抑制 Nrf2 来减弱 MSU 晶体诱导的 NLRP3 炎症小体激活,通过 FPR2-IRF 途径调节 M1/M2 巨噬细胞极化。Lipoxin 抑制氧化应激和炎症。 |