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Search Results for " 15lipoxin a4 "
Targets Recommended: Others

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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T37265 15(R)-Lipoxin A4

15(R)-Lipoxin A4,AT-Lipoxin A4

Others Others
Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may...
T37305 6(S)-Lipoxin A4

6(S)-Lipoxin A4

Others Others
The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene. Lipoxin A4 (LXA4) was first described as a metabolite of 15-HpETE and/or 15-HETE when added in vitro to isolated human leukocytes. The material obtained in this manner consists of at least four distinct isomers: 5(S), 6(S); 5(S), 6(R); and the 11-trans and 11-cis isomers of each of these. 6(S)-LXA4 is one of the original four metabolites first identified by Serhan, Nicolaou, and Samuelsson. It was considered to b...

化合物

15(R)-Lipoxin A4
Cat.No: T37265
Synonym: 15(R)-Lipoxin A4,AT-Lipoxin A4
Target: Others
6(S)-Lipoxin A4
Cat.No: T37305
Synonym: 6(S)-Lipoxin A4
Target: Others
Cat. No. Product Name Target Signaling Pathways
T36051 Lipoxin A4

LXA4

Endogenous Metabolite; Interleukin Immunology/Inflammation; Metabolism
Lipoxin A4 (LXA4) 是一种内源性脂氧合酶衍生的类花生酸介质,具有抗炎作用。Lipoxin A4 通过抑制 Nrf2 来减弱 MSU 晶体诱导的 NLRP3 炎症小体激活,通过 FPR2-IRF 途径调节 M1/M2 巨噬细胞极化。Lipoxin 抑制氧化应激和炎症。

天然产物

Lipoxin A4
Cat.No: T36051
Synonym: LXA4
Target: Endogenous Metabolite, Interleukin
TargetMol Loading
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