2
2
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0977 |
Medrysone
Gimeracil,6α-Methyl-11β-hydroxyprogesterone,6A-甲基-11B-羟孕酮,甲羟松 |
Glucocorticoid Receptor; Others | Endocrinology/Hormones; Others |
Medrysone (6α-Methyl-11β-hydroxyprogesterone) 是局部合成的糖皮质激素,具有代谢、抗炎和抗过敏特性,有潜力用于眼科的眼炎症研究。 | |||
T84842 |
11alpha-Hydroxyprogesterone
|
Others | Others |
11alpha-Hydroxyprogesterone 是11beta-Hydroxyprogesterone 的非活性模拟物,通常用作实验对照。11beta-Hydroxyprogesterone 为11β-羟基甾类脱氢酶(11β-Hydroxysteroid dehydrogenase)的高效抑制剂,并能在COS-7细胞中激活人类盐皮质激素受体,具有10 nM的ED50值。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TCA2511 |
11Beta-hydroxyprogesterone
11β-Hydroxyprogesterone |
Dehydrogenase | Metabolism |
11Beta-hydroxyprogesterone (11β-Hydroxyprogesterone)是 11β-羟基类固醇脱氢酶 (11betaHSD) 2 型的抑制剂,可在COS-7细胞中激活人类盐皮质激素受体,可用于研究代谢相关疾病。 | |||
T36915 |
21-Deoxycortisol
|
Others | Others |
21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMID-0112 |
21-Deoxycortisol-d8
|
||
21-Deoxycortisol-d8 是 21-Deoxycortisol 的氘代化合物。21-Deoxycortisol 的 CAS 号为 641-77-0。 |