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Search Results for " (lps)-induced "

Targets Recommended: Glucocorticoid Receptor Mitophagy IL Receptor Annexin A NOS Antibacterial Autophagy ADC Cytotoxin

125

抑制剂 & 化合物

120

天然产物

6

重组蛋白

5

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T0947	Dexamethasone acetate Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471	Glucocorticoid Receptor; Mitophagy; IL Receptor; Annexin A; NOS; Antibacterial; Autophagy; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone acetate (NSC 39471) 是一种糖皮质素类甾体，有抗炎和免疫抑制活性。它可研究眼部感染。
T37292	M62812	TLR	Immunology/Inflammation
	M62812是一种 TLR4抑制剂，可在 HEK239细胞中抑制 LPS 诱导的NF-κB 活化。
T21853	(E)-AG 556	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	(E)-AG 556 是有效的、选择性 EGFR 抑制剂。(E)-AG 556阻断 LPS 诱导的促炎因子 TNF-α 的产生。
T9581	ARRY-797 ARRY-371797	IL Receptor; p38 MAPK	Immunology/Inflammation; MAPK
	ARRY-797 (ARRY-371797) 是一种有效的选择性 p38α 抑制剂，可抑制 LPS 诱导的 IL-6。
T11069	DO-264	Others	Others
	DO-264 是一种自水解酶结构域 12 (ABHD12) 的抑制剂(IC50：11 nM)，也是一种细胞LysoPS降解抑制剂，可增强 LPS 诱导的吞噬作用。
T5101	BW-A 78U BW-A78U	PDE	Metabolism
	BW-A 78U 抑制 PDE4，其 IC50值为 3 μM。
T77484	Atibuclimab	TNF	Apoptosis
	Atibuclimab 是一种靶向 CD14 的嵌合单克隆抗体，由小鼠可变区和人类 IgG4 Fc 区构成。Atibuclimab 可用于治疗肌萎缩侧索硬化症。Atibuclimab 可减少 LPS 诱导的病症，并对 LPS 诱导的促炎细胞因子释放有抑制作用，可延迟抗炎细胞因子可溶性 TNF 受体 I 型的释放，
T27841	Lobeglitazone Sulfate CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang	NOD	Immunology/Inflammation; NF-κB
	Lobeglitazone Sulfate（CKD-501 Sulfate）是一种新型噻唑烷二酮,具有抗炎活性，抑制LPS诱导的NLRP3炎症小体活化和肝脏炎症，可用于研究 2 型糖尿病 (T2DM)。
T63067	Emprumapimod PF-07265803,ARRY-371797	p38 MAPK	MAPK
	Emprumapimod (PF-07265803) 是一种具有口服活性和特异性的丝裂原活化蛋白激酶 p38α MAPK 抑制剂，抑制 LPS 诱导产生的 IL-6 ，可用于研究 LMNA 基因引起的扩张型心肌病。
T36524	IKK2-IN-4 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide,IKK2 Inhibitor IV	IκB/IKK; TNF	Apoptosis; NF-κB
	IKK2-IN-4 (IKK2 Inhibitor IV)是一种高效的 IKK-2 抑制剂，IC50 值为 25 nM。IKK2-IN-4 对 LPS 诱导的 PBMC 中 TNFα 的产生有抑制作用。
T23636	Adenosine N1-oxide ANO,1-Oxoadenosine,Adenosine N1 oxide,Adenosine, 1-oxide,腺苷氮氧化物	Immunology/Inflammation related	Immunology/Inflammation
	Adenosine N1-oxide (1-Oxoadenosine) 是在蜂王浆中发现的腺苷 N1-氧化物，可抑制活化的巨噬细胞分泌炎症介质，并降低脂多糖 (LPS) 诱导的内毒素休克的致死率。
T11139	(E/Z)-BCI NSC 150117	Apoptosis; Phosphatase	Apoptosis; Metabolism
	(E/Z)-BCI (NSC-150117) 是一种DUSP6抑制剂，可通过激活 Nrf2 信号和抑制 NF-κB 通路，减弱 LPS 诱导的巨噬细胞炎症和 ROS 生成，具有抗炎活性。
T64359	Anti-inflammatory agent 36	Immunology/Inflammation related	Immunology/Inflammation
	Anti-inflammatory agent 36 是一种抗炎剂。它对LPS 诱导的RAW 264.7细胞释放TNF-a 和IL-6具有剂量依赖性的抑制作用，IC50分别为3.69uM 和3.68uM。
T32613	LCB 03-0110 dihydrochloride	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	LCB 03-0110 Dihydrochloride 是BTK 和SYK 家族以及DDR2家族中c-Src 激酶（IC50=1.3 nM）和酪氨酸激酶的有效抑制剂。在体外抑制LPS 诱导的巨噬细胞活化和TGF-β1诱导的成纤维细胞活化，抑制巨噬细胞和成纤维细胞的活化，并抑制伤口愈合模型中的瘢痕形成。
T1076	Dexamethasone MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松	Glucocorticoid Receptor; Mitophagy; IL Receptor; SARS-CoV; Antibacterial; Antibiotic; Autophagy; Complement System; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone (Hexadecadrol) 是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。Dexamethasone 具有抗炎和免疫抑制活性，可诱导自噬。Dexamethasone 抑制 LPS 诱导的巨噬细胞炎症反应。
T2188	Thonzonium Bromide 嘧苯十六铵,通佐溴胺	Proton pump; Antibacterial; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Thonzonium bromide 是一种单阳离子表面活性剂，在结构上与 Farnesol 相似的抗菌剂。它以剂量依赖的方式抑制质子转运 (EC50=69 μM)。在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收，并在体内阻止 LPS 诱导的骨丢失。
T12781	RV01	Others	Others
	RV01 是一种新型的白藜芦醇喹啉取代类似物，可抑制 DNA 损伤，降低乙醇诱导的乙醛脱氢酶 (ALDH2) 的 mRNA 表达，具有清除羟自由基的活性。RV01 降低 iNOS 的表达，具有抗神经炎症作用。RV01降低肿瘤坏死因子-a (TNF-a)和白细胞介素-6 (IL-6) mRNA 水平和分泌，抑制lps 诱导的ROS 生成和烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶活化，降低toll 样受体4 (TLR4)的蛋白表达，抑制lps 诱导的丝裂原活化蛋白激酶(MAPK)和核转录因子-кB (NF-кB)信号通路的激活。
T2367	SKF-86002 SKF86002	p38 MAPK; TNF	Apoptosis; MAPK
	SKF-86002 是一种可口服的 p38 MAPK 抑制剂，具有抗炎和抗关节炎活性，可用于缓解疼痛的研究。它能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢，还抑制脂多糖 (LPS) 刺激人单核细胞产生 IL-1 和 TNF-α，IC50为 1 μM。
T33514	MSC 2032964A MSC-2032964A,MSC2032964A	ASK	Apoptosis
	MSC 2032964A 是一种有效的选择性 ASK1 抑制剂 (IC50 = 93 nM)，具有口服生物利用度和脑渗透性。它在小鼠 EAE 模型中抑制神经炎症，并在培养的小鼠星形胶质细胞中阻断 LPS 诱导的 ASK1 和 p38 磷酸化。
T9543	Syk Inhibitor II hydrochloride	Others	Others
	Syk Inhibitor II hydrochloride 信号传导的影响在狼疮中可能很突出。
T63119	NF-κB/MAPK-IN-1	NF-κB; MAPK	MAPK; NF-κB
	NF-κB/MAPK-IN-1 是一种有效的 NF-κB 和 MAPK 通路双重抑制剂，具有潜在的抗炎活性，抑制 NO 生成，对 LPS 诱导的iNOS，COX-2，ERΚ和P38激活有抑制作用。 NF-κB/MAPK-IN-1 可用于预防和治疗类风湿关节炎 (RA) 。
T60857	MKK7-COV-9	Others	Others
	MKK7-COV-9 是一种具有选择性和有效性的 MKK7 共价抑制剂，对 MKK7 引导的蛋白-蛋白相互作用有抑制作用。MKK7-COV-9 中断原代 B 细胞应对 LPS 的激活。MKK7-COV-9 在高浓度下显示出较低的细胞毒性。
T25752	Lonchocarpic acid AI3-01135,AI301135,AI3 01135	Others	Others
	Lonchocarpic acid shows an anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation.
T24262	KL-1156	Others	Others
	KL-1156 is an NF-κB inhibitor. It is also a lipopolysaccharide (LPS)-induced nitric oxide production inhibitor.
T71240	AS 703026	Others	Others
	AS 703026 has been shown to inhibit LPS-induced TNFα production in macrophages/monocytes as well as protect from LPS-induced endotoxin shock. AS 703026 may be useful as an anti-inflammatory therapy for COPD patients.
T27752	KT109 KT-109,KT 109	Others	Others
	KT109 is a selective inhibitor of DAGLβ (IC50 = 42 nM). KT109-treated wild-type mice displayed reductions in LPS-induced allodyni as well as in DAGL-β (-/-) micea. Repeated KT109 administration prevented the expression of LPS-induced allodynia, without ev
T36169	15-LOX-1 inhibitor 1	Others	Others
	9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF- B activity in RAW-Blue cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM.
T70145	LYRM03	Others	Others
	LYRM03 is an aminopeptidase inhibitor. LYRM03 is also an ubenimex derivative. LYRM03 attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. LYRM03 effectively attenuates LPS-induced ALI by inhibiting the expression of pro-inflammatory mediators and Myd88-dependent TLR4 signaling pathways in alveolar macrophages. LYRM03 may serve as a potential treatment for sepsis-mediated lung injuries.
T70367	SNU-BP	Others	Others
	SNU-BP is an agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines. SNU-BP potentiates interleukin-4-induced arginase-1 expression, and promotes microglial polarization toward an M2 anti-inflammatory phenotype.
T38384	Nexinhib20	Others	Others
	Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 μM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflamma...
T38366	CAY10614 CAY10614	Others	Others
	CAY10614 是一种 TLR4 拮抗剂。 CAY10614 可抑制脂质 A 诱导激活的 TLR4 （IC50=1.675 μM）。CAY10614 还可以 LPS 诱导的休克模型小鼠的存活率。
T83051	Anti-inflammatory agent 61	Others	Others
	Anti-inflammatory agent 61 (Compound 5b)为一种高效抗炎化合物，能够降低LPS诱导的RAW 264.7细胞中的TNF-α表达，并可缓解APAP引起的HepG2细胞炎症。
T78032	Endotoxin inhibitor TFA
	Endotoxin inhibitor TFA 是一种可以与脂多糖(LPS)的成分脂质A高亲和力结合的合成肽，具有中和LPS毒性、预防LPS引发的细胞因子释放的作用。此外，Endotoxin inhibitor TFA能够有效抑制LPS引起的发热反应，同时具有极低的毒性和致死率。
T40225	JH-X-119-01 hydrochloride	Others	Others
	JH-X-119-01 hydrochloride is a potent and selective inhibitor of interleukin-1 receptor-associated kinases 1 (IRAK1). It effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.
TP1978	11R-VIVIT NFAT inhibitor, Cell Permeable
	NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse
T80465	CRAMP (140-173) (mouse)
	CRAMP (140-173) (mouse)，作为人LL-37抗菌肽的同源物，能够抑制LPS诱导的反应，但在BEAS-2B细胞中不与TLR3发生共定位。
T73580	8A8	NO Synthase	Immunology/Inflammation
	8A8 作为促炎因子NO的有效抑制剂，具有4.7 μM的 IC50 值，并显著抑制由 LPS 诱导的 HaCat 细胞增殖。
T79999	NF-κB-IN-13	NF-κB	NF-κB
	NF-κB-IN-13（compound 12）在RAW264.7巨噬细胞中显著抑制了LPS诱导的NF-κB激活以及NO生成，表现出其抗炎效果。
T83049	Anti-inflammatory agent 63	Others	Others
	Anti-inflammatory agent 63，在RAW264.7细胞中对脂多糖 (LPS) 诱导的一氧化氮 (NO) 产生显示最佳抑制效果，其半抑制浓度(EC50)为5.33±0.57 μM。
T72202	Anti-inflammatory agent 33	Others	Others
	Anti-inflammatory agent 33，一种有效的p38α抑制剂，抑制NO产生，并抑制LPS诱导的iNOS、COX-2、p-p38α、p-MK2蛋白表达，具有抗炎活性。
T69671	SR1903 TFA	Others	Others
	SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-190...
T16477	PF-03715455	p38 MAPK	MAPK
	PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM). PF-0371545
T68738	(±)-γ-Tocopherol	Others	Others
	(±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. It traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays. It also reduces the synthesis of prostaglandin E2 (PGE2) induced by LPS in RAW 264.7 macrophages and by IL-1β in A549 cells. (±)-γ-Tocopherol inhibits LPS-induced nitrite release and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells and reduces COX-2 activity in A549 cells pretreated...
T77851	INX-SM-6	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	INX-SM-6适用于靶向输送抗炎药物。它能在PBMCS细胞中抑制LPS引发的IL-1β产生。
T68321	AS1940477	Others	Others
	AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent c...
T9655	NBC 6	Others	Others
	NLRP3-IN-NBC6 是一种有效的选择性 NLRP3炎性小体抑制剂，IC50为574 nM，其作用独立于 Ca2+。NLRP3-IN-NBC6 抑制 Nigericin 诱导的 THP-1 细胞炎症反应和 Imiquimod 诱导的 LPS-primed 的骨髓源性巨噬细胞 (BMDMs) 释放 IL-1β。
T72412	Antimicrobial agent-5	Others	Others
	Antimicrobial agent-5 是一种强效抗菌剂，对革兰氏阳性菌/阴性菌展示出良好的细胞选择性。通过阻断LPS与CD14/TLR4受体之间的交互作用，Antimicrobial agent-5 显示出抗炎活性并能缓解LPS引发的炎症反应。
T36355	Sydowinin B	Others	Others
	Sydowinin B is a xanthone polyketide that has been found inA. sydowiiand has immunosuppressant activity.1It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20.8 μg/ml, respectively).2Sydowinin B inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by cytochalasin B and N-Formyl-Met-Leu-Phe with IC50values of 21.2 and 12.62 μM, respectively.3
T63261	iNOs-IN-3	Others	Others
	iNOs-IN-3 是口服具有活力的一氧化氮合成酶 (iNOS) 抑制剂，IC50 值为 3.342 μM，表现出抗炎作用，能够用于研究 LPS 诱导的急性肺损伤 (ALI) 。
T35864	T-5342126	Others	Others
	T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-depen...

化合物

Dexamethasone acetate

Cat.No: T0947

Synonym: Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, Annexin A, NOS, Antibacterial, Autophagy, ADC Cytotoxin

Cat.No: T37292

Target: TLR

Cat.No: T21853

Target: EGFR

Cat.No: T9581

Synonym: ARRY-371797

Target: IL Receptor, p38 MAPK

Cat.No: T11069

Target: Others

Cat.No: T5101

Synonym: BW-A78U

Target: PDE

Cat.No: T77484

Target: TNF

Lobeglitazone Sulfate

Cat.No: T27841

Synonym: CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang

Target: NOD

Cat.No: T63067

Synonym: PF-07265803,ARRY-371797

Target: p38 MAPK

Cat.No: T36524

Synonym: 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide,IKK2 Inhibitor IV

Target: IκB/IKK, TNF

Adenosine N1-oxide

Cat.No: T23636

Synonym: ANO,1-Oxoadenosine,Adenosine N1 oxide,Adenosine, 1-oxide,腺苷氮氧化物

Target: Immunology/Inflammation related

Cat.No: T11139

Synonym: NSC 150117

Target: Apoptosis, Phosphatase

Anti-inflammatory agent 36

Cat.No: T64359

Target: Immunology/Inflammation related

LCB 03-0110 dihydrochloride

Cat.No: T32613

Target: Src

Cat.No: T1076

Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System, ADC Cytotoxin

Thonzonium Bromide

Cat.No: T2188

Synonym: 嘧苯十六铵,通佐溴胺

Target: Proton pump, Antibacterial, Autophagy

Cat.No: T12781

Target: Others

Cat.No: T2367

Synonym: SKF86002

Target: p38 MAPK, TNF

Cat.No: T33514

Synonym: MSC-2032964A,MSC2032964A

Target: ASK

Syk Inhibitor II hydrochloride

Cat.No: T9543

Target: Others

NF-κB/MAPK-IN-1

Cat.No: T63119

Target: NF-κB, MAPK

Cat.No: T60857

Target: Others

Lonchocarpic acid

Cat.No: T25752

Synonym: AI3-01135,AI301135,AI3 01135

Target: Others

Cat.No: T24262

Target: Others

Cat.No: T71240

Target: Others

Cat.No: T27752

Synonym: KT-109,KT 109

Target: Others

15-LOX-1 inhibitor 1

Cat.No: T36169

Target: Others

Cat.No: T70145

Target: Others

Cat.No: T70367

Target: Others

Cat.No: T38384

Target: Others

Cat.No: T38366

Synonym: CAY10614

Target: Others

Anti-inflammatory agent 61

Cat.No: T83051

Target: Others

Endotoxin inhibitor TFA

Cat.No: T78032

JH-X-119-01 hydrochloride

Cat.No: T40225

Target: Others

Cat.No: TP1978

Synonym: NFAT inhibitor, Cell Permeable

CRAMP (140-173) (mouse)

Cat.No: T80465

Cat.No: T73580

Target: NO Synthase

Cat.No: T79999

Target: NF-κB

Anti-inflammatory agent 63

Cat.No: T83049

Target: Others

Anti-inflammatory agent 33

Cat.No: T72202

Target: Others

Cat.No: T69671

Target: Others

Cat.No: T16477

Target: p38 MAPK

(±)-γ-Tocopherol

Cat.No: T68738

Target: Others

Cat.No: T77851

Target: Others, ADC Cytotoxin

Cat.No: T68321

Target: Others

Cat.No: T9655

Target: Others

Antimicrobial agent-5

Cat.No: T72412

Target: Others

Cat.No: T36355

Target: Others

Cat.No: T63261

Target: Others

Cat.No: T35864

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2988	(-)-Epigallocatechin Gallate Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG	Ferroptosis; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	(-)-Epigallocatechin Gallate (EGCG) 属于茶类黄酮天然产物，可抑制 EGFR 信号传导，抑制 GLUD 1/2。(-)-Epigallocatechin Gallate 具有抗氧化、抗炎和抗肿瘤活性。(-)-Epigallocatechin Gallate 可以通过激活细胞色素 c 氧化酶来诱导氧化磷酸化。
TN6714	Geranylgeraniol FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095	Apoptosis	Apoptosis
	Geranylgeraniol (FT0626663) 是一种类异戊二烯，存在于水果、蔬菜和谷物中，包括大米。 Geranylgeraniol (FT0626663) 抑制生长并诱导各种肿瘤细胞的凋亡。 Geranylgeraniol (FT0626663) 保护单核细胞免受他汀类药物诱导的细胞毒性并抑制分枝杆菌的生长。
T5764	Alliin 蒜氨酸,(S)-3-(Allylsulphinyl)-L-alanine	NF-κB; PPAR	DNA Damage/DNA Repair; Metabolism; NF-κB
	Alliin ((S)-3-(Allylsulphinyl)-L-alanine) 是一种从大蒜中提取的亚砜化合物，具有口服活性，表现出降血糖、抗氧化和抗炎特性。
TN4956	Scandoside	NF-κB; MAPK	MAPK; NF-κB
	Scandoside exerts anti-inflammatory effect via suppressing NF-ÎºB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidation.
TN1553	Deacetyl ganoderic acid F	Others	Others
	Deacetyl ganoderic acid F (DeGA F) 是从灵芝 Ganoderma lucidum 中提取的三萜类化合物，在体外和体内对脂多糖（LPS）诱导的炎症有抑制作用。
T5S0734	Desmethoxyyangonin Desmethoxy yangonin,去甲氧基醉椒素,Demethoxyyangonin,5,6-Dehydrokavain	Others; Monoamine Oxidase	Neuroscience; Others
	Desmethoxyyangonin (5,6-Dehydrokavain) 是一种MAO-B 可逆性抑制剂。
TN2461	Loganic acid 6′-O-β-D-glucoside 8-Epi-Loganic acid-6'-O-β-D-glucoside	Others	Others
	Loganic acid 6′-O-β-D-glucoside (8-Epi-Loganic acid-6'-O-β-D-glucoside) 是 Cistanche deserticola 的天然产物，可抑制 LPS 诱导的 NO 和 TNF-α 的产生。
T6S0107	Peimine 贝母素甲,Wanpeinine A,Dihydroisoimperialine,Verticine,贝母甲素	Others	Others
	Peimine (Wanpeinine A) 是一种天然化合物，具有很好抗炎症活性。
T4951	kauran-16,17-diol	Apoptosis; Others	Apoptosis; Others
	Kauran-16,17-diol 是一个天然的二萜天然产物，抑制 LPS 诱导的RAW 264.7 细胞产生 NO 的IC50值为17 μM，具有抗肿瘤诱导凋亡的活性。
TN2091	Polygalacin D	Apoptosis; IAP	Apoptosis
	Polygalacin D 是从桔梗中分离的一种天然产物，具有抗癌和抗增殖特性。它通过 PI3K/Akt 途径诱导凋亡。它抑制 IAP 蛋白家族的表达，并通过抑制 GSK3β，Akt 的磷酸化和 PI3K 的表达来阻断 PI3K/Akt 途径。
T3926	Echinatin 刺甘草查尔酮,Retrochalcone	Free radical scavengers	oxidation-reduction
	Echinatin (Retrochalcone) 是分离自中草药甘草中，具有保肝和抗炎活性。在大鼠中，它可以被快速吸收和消除，并广泛分布，绝对生物利用度约为 6.81％。
TN1879	Lucideric acid A Lucidenic acid A,赤芝酸A	MMP; p38 MAPK; JNK	MAPK; Proteases/Proteasome
	Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物，可抑制 PMA 诱导的MMP-9活性，具有抵抗肝癌细胞侵袭的作用。
T3S1692	Octahydrocurcumin	Anti-infection; NF-κB; Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Octahydrocurcumin 是一种姜黄素的氢化衍生物，是姜黄素的代谢物。
TN7235	4-methoxylonchocarpin	TNF; NF-κB	Apoptosis; NF-κB
	4-methoxylonchocarpin 是从Abrus precatorius 的根中分离出来的以一种有效的抗炎化合物。4-methoxylonchocarpin 通过抑制LPS 与巨噬细胞的TLR4结合来抑制NF-κB 激活TNF 表达，抑制TNBS 引起的小鼠结肠炎。
T5660	Menthone	IL Receptor; TNF; NF-κB; Parasite	Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Menthone 是一种从植物和薄荷油中提取的单萜，是精油的主要挥发性成分，具有抗炎和抗氧化特性。
T3914	Saikosaponin C 柴胡皂苷C,柴胡皂苷 C	Beta Amyloid; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	Saikosaponin C 是一种柴胡中的活性成分，能够抑制 Aβ1-40 和 Aβ1-42 的释放，抑制异常 tau 蛋白的磷酸化，但对 BACE1 的活性和表达无作用。它在阿尔滋海默症中主要靶作用于amyloid beta 和tau 蛋白。
TN6694	5,6-Benzoflavone β-Naphthoflavone,beta-NF	Antioxidant	oxidation-reduction
	5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。
TN1828	Kahweol	Apoptosis; NF-κB; AMPK	Apoptosis; Chromatin/Epigenetic; NF-κB; PI3K/Akt/mTOR signaling
	Kahweol 是小果咖啡的成分之一，可诱导细胞凋亡，具有抗炎、抗血管生成和抗癌活性。它通过激酶的活化抑制的脂肪生成和增加葡萄糖摄取。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
TN6985	Anhydronotoptol	NO Synthase	Immunology/Inflammation
	Anhydronotoptol (4-{[(2E,5E)-3,7-dimethylocta-2,5,7-trien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one) 是一种可从伞科植物羌活中提取得到的天然化合物。Anhydronotoptol 是一种有效的一氧化氮生成抑制剂，抑制 LPS 诱导的 RAW 264.7 细胞 NO 生成，其 IC50 值为 36.6 μM。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
TN1134	Euscaphic acid	Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling
	Euscaphic acid 是来源于枣的一种三萜，是DNA 聚合酶抑制剂，可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。
TQ0218	Deoxyandrographolide 去氧穿心莲内酯,14-deoxyandrographolide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Deoxyandrographolide (14-deoxyandrographolide) 抑制 LPS 诱导的 iNOS mRNA 水平升高以及促炎症介质 TNF-α 和 IL-6 的产生。它增强 NGF 诱导的神经突起生长。
TN1936	Mogroside III-E 罗汉果皂苷ⅢE	IL Receptor; TNF; TLR	Apoptosis; Immunology/Inflammation
	Mogroside IIIe 是一种葫芦烷型化合物，从罗汉果中分离得到，可抑制 NO 的释放，具有抗肺纤维化作用。
T5S1981	alpha-Cyperone (+)-α-Cyperone,α-香附酮,α-Cyperone	Others; Endogenous Metabolite	Metabolism; Others
	alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。
T3877	Esculentoside A	NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Esculentoside A 是一种三萜皂苷，从商陆根部分离得到。它在具有抗炎活性，对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。
T5S2059	Glaucine	Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Glaucine 是从海罂粟中分离的一种生物碱，具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂，具有抗氧化和抗病毒活性。
T6S0653	Linarin Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷	TNF; AChE	Apoptosis; Neuroscience
	Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂，从薄荷花提取物中分离得到。
T6S1572	Sauchinone	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。
T7030	anemarsaponin B 知母皂苷B,知母皂苷 B	p38 MAPK; NF-κB; MEK; COX; NO Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Anemarsaponin B 是一种甾体皂苷，可降低iNOS 和COX-2的蛋白和 mRNA 水平，减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位，还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。
T2978	Mogroside V	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Mogroside V 是三萜糖苷，是非糖类甜味剂，甜度比蔗糖甜高300倍。它具有抗氧化，抗糖尿病和抗癌作用。
T6S2140	β-Anhydroicaritin Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素	MMP; Others; TNF; Interleukin	Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome
	β-Anhydroicaritin 是从乳香提取的一种天然产物，具有重要的生物学和药理学作用，如抗骨质疏松症，雌激素调节和抗肿瘤特性。它改善牙周组织的降解，抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高，并显著降低 iNOS 蛋白的表达。
T5S0045	Isofraxidin 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶	MMP; ERK; p38 MAPK; TLR; COX	Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
T6S1256	Ruscogenin	NOS; NF-κB; NOD-like Receptor (NLR)	Immunology/Inflammation; NF-κB
	Ruscogenin 是一种重要甾体皂苷元，提取自麦冬。它能够抑制 TXNIP/NLRP3炎症体激活和 MAPK 途径，改善脑缺血诱导的血脑屏障功能障碍，具有显著抗血栓、抗炎作用。
T6S1579	Monotropein 水晶兰苷,Monotropeine	Others	Others
	Monotropein (Monotropeine) 是从Morinda officinalis 中获得，能够抑制硫酸葡聚糖硫酸钠诱导的结肠炎小鼠模型中炎性因子的表达。
T3676	Sesamol 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分，具有抗氧化和抗肿瘤活性。它是一种自由基清除剂，在 DPPH 实验中，IC50为 5.95±0.56 μg/mL。
T3929	Kaurenoic acid Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid	Others	Others
	Kaurenoic acid (kaurenoate) 是一种二萜，来源于 Sphagneticola trilobata 中，可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路，并抑制炎症疼痛。
T4S1540	Myrislignan	Apoptosis; NF-κB	Apoptosis; NF-κB
	Myrislignan 是一种木酚素，从Myristica fragransHoutt 分离得到，具有抗炎作用。它通过抑制NF-kB 信号通路的激活，减轻LPS 诱导的小鼠巨噬细胞炎症反应。
T4S2063	Tetrahydrocoptisine 人血草碱,STYLOPINE	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Tetrahydrocoptisine (STYLOPINE) 具有抑制炎症的有效作用。它通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用，这可能涉及抑制肺部炎症过程。它具有胃保护活性，归因于减少 NO 产生和调节促炎细胞因子，抑制中性粒细胞积累和 NF-κB 表达。它是一种活性抗炎成分，通过下调 NF-κB 活化、磷酸化 ERK1/2 和磷酸化-p38MAPK 信号通路抑制 TNF-α、IL-6 和 NO 的产生。
T2S2264	Linalool Linalol,(±)-Linalool,Phantol,沉香醇	Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA 受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。
T3S0737	Flavokawain A 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A	Apoptosis; p38 MAPK	Apoptosis; MAPK
	Flavokawain A (Flavokavain A) 是 kava 提取物中的查耳酮，是一种抗癌试剂，具有抗肿瘤活性。它通过 Bax 蛋白依赖和线粒体依赖的凋亡途径诱导细胞凋亡，有潜力用于膀胱癌的相关研究。
T3673	Mollugin 大叶茜草素,Rubimaillin	HER; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。
T6S0735	Flavokawain B 黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis; Others	Apoptosis; Others
	Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中，分离出的查尔酮。它是一种凋亡诱导剂，可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成，具有抗血管生成活性。
T4S0350	Licochalcone B 甘草查尔酮 B,甘草查尔酮B	Beta Amyloid; Others	Neuroscience; Others
	Licochalcone B 是从Glycyrrhiza inflate 根中提取的。它能够抑制淀粉样蛋白 β 自聚集作用 (IC50=2.16 μM) ，分解预先形成的 Aβ42原纤维，并通过螯合金属离子抑制金属诱导的 Aβ42聚集。
T5S0106	Peimisine 贝母辛,Ebeiensine	RAAS; AChR	Endocrinology/Hormones; Neuroscience
	Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体，抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放，促进一氧化氮释放，可舒张气管平滑肌，有平喘作用。
T13880	Salirepin	Others	Others
	Salirepin is a phenolic glycoside isolated from fruits of Idesia polycarpa, Salirepin inhibits LPS-induced nitric oxide production.
TN3839	Desoxo-narchinol A	ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; Prostaglandin Receptor; JNK	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO production. Desoxo-narchinol A shows cytotoxic activity against P-388 cells.
TN4244	Icariside B1 淫羊藿次甙B1	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Icariside B1 shows inhibitory effects on LPS-induced NO production in RAW264.7 cells.
TN4409	Lansiumarin C	TNF	Apoptosis
	Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages.
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天然产物

(-)-Epigallocatechin Gallate

Cat.No: T2988

Synonym: Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG

Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy

Geranylgeraniol

Cat.No: TN6714

Synonym: FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095

Target: Apoptosis

Cat.No: T5764

Synonym: 蒜氨酸,(S)-3-(Allylsulphinyl)-L-alanine

Target: NF-κB, PPAR

Cat.No: TN4956

Target: NF-κB, MAPK

Deacetyl ganoderic acid F

Cat.No: TN1553

Target: Others

Desmethoxyyangonin

Cat.No: T5S0734

Synonym: Desmethoxy yangonin,去甲氧基醉椒素,Demethoxyyangonin,5,6-Dehydrokavain

Target: Others, Monoamine Oxidase

Loganic acid 6′-O-β-D-glucoside

Cat.No: TN2461

Synonym: 8-Epi-Loganic acid-6'-O-β-D-glucoside

Target: Others

Cat.No: T6S0107

Synonym: 贝母素甲,Wanpeinine A,Dihydroisoimperialine,Verticine,贝母甲素

Target: Others

kauran-16,17-diol

Cat.No: T4951

Target: Apoptosis, Others

Cat.No: TN2091

Target: Apoptosis, IAP

Cat.No: T3926

Synonym: 刺甘草查尔酮,Retrochalcone

Target: Free radical scavengers

Lucideric acid A

Cat.No: TN1879

Synonym: Lucidenic acid A,赤芝酸A

Target: MMP, p38 MAPK, JNK

Octahydrocurcumin

Cat.No: T3S1692

Target: Anti-infection, NF-κB, Reactive Oxygen Species, ROS

4-methoxylonchocarpin

Cat.No: TN7235

Target: TNF, NF-κB

Cat.No: T5660

Target: IL Receptor, TNF, NF-κB, Parasite

Cat.No: T3914

Synonym: 柴胡皂苷C,柴胡皂苷 C

Target: Beta Amyloid, Caspase

5,6-Benzoflavone

Cat.No: TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Cat.No: TN1828

Target: Apoptosis, NF-κB, AMPK

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

Anhydronotoptol

Cat.No: TN6985

Target: NO Synthase

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: TN1134

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Deoxyandrographolide

Cat.No: TQ0218

Synonym: 去氧穿心莲内酯,14-deoxyandrographolide

Target: IL Receptor, TNF

Mogroside III-E

Cat.No: TN1936

Synonym: 罗汉果皂苷ⅢE

Target: IL Receptor, TNF, TLR

Cat.No: T5S1981

Synonym: (+)-α-Cyperone,α-香附酮,α-Cyperone

Target: Others, Endogenous Metabolite

Esculentoside A

Cat.No: T3877

Target: NF-κB, COX

Cat.No: T5S2059

Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE

Cat.No: T6S0653

Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷

Target: TNF, AChE

Cat.No: T6S1572

Target: ERK, p38 MAPK, NF-κB

anemarsaponin B

Cat.No: T7030

Synonym: 知母皂苷B,知母皂苷 B

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

Cat.No: T2978

Target: AMPK

β-Anhydroicaritin

Cat.No: T6S2140

Synonym: Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素

Target: MMP, Others, TNF, Interleukin

Cat.No: T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶

Target: MMP, ERK, p38 MAPK, TLR, COX

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

Cat.No: T6S1256

Target: NOS, NF-κB, NOD-like Receptor (NLR)

Cat.No: T6S1579

Synonym: 水晶兰苷,Monotropeine

Target: Others

Cat.No: T3676

Synonym: 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚

Target: Apoptosis, AMPK

Cat.No: T3929

Synonym: Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid

Target: Others

Cat.No: T4S1540

Target: Apoptosis, NF-κB

Tetrahydrocoptisine

Cat.No: T4S2063

Synonym: 人血草碱,STYLOPINE

Target: ERK, p38 MAPK, NF-κB

Cat.No: T2S2264

Synonym: Linalol,(±)-Linalool,Phantol,沉香醇

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Cat.No: T3S0737

Synonym: 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A

Target: Apoptosis, p38 MAPK

Cat.No: T3673

Synonym: 大叶茜草素,Rubimaillin

Target: HER, JAK

Cat.No: T6S0735

Synonym: 黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone

Target: Apoptosis, Others

Cat.No: T4S0350

Synonym: 甘草查尔酮 B,甘草查尔酮B

Target: Beta Amyloid, Others

Cat.No: T5S0106

Synonym: 贝母辛,Ebeiensine

Target: RAAS, AChR

Cat.No: T13880

Target: Others

Desoxo-narchinol A

Cat.No: TN3839

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, Prostaglandin Receptor, JNK

Cat.No: TN4244

Synonym: 淫羊藿次甙B1

Target: Akt

Cat.No: TN4409

Target: TNF

--------- 更多 ---------

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02904	TLR4 Protein, Human, Recombinant (His) TLR-4,TOLL,toll-like receptor 4,ARMD10,TLR4,CD284	Human	Baculovirus Insect Cells
	TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed...
TMPJ-01341	CCL24 Protein, Mouse, Recombinant Scya24,Eosinophil chemotactic protein 2,Small-inducible cyto...	Mouse	E. coli
	Mouse CCL24 is a secreted protein, which is a member of the CC chemokine subfamily. Mouse Ccl24 cDNA encodes a 119 amino acid residue precursor protein, shares approximately 58% amino acid sequence identity with human Ccl24. It is predominantly expressed in the jejunum and spleen and also be induced in the lung by allergen challengeand IL4. Mouse ccl24 has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Ccl24 is chemotactic for resting T-lymphocytes, ...
TMPJ-00527	SP-D Protein, Human, Recombinant (His) Lung Surfactant Protein D,SFTP4,COLEC7,SFTPD,PSP-D,SP-D,Pulm...	Human	HEK293 Cells
	Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators. Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognition domain (CRD), a structure that places it in a subset of pattern recognition proteins termed defense collagens. SP-D is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures and induced in cardiac smooth muscle and endothelial cells. ...
TMPH-02585	ACOD1 Protein, Mouse, Recombinant (His & Myc) Cis-aconitate decarboxylase,Cis-aconitic acid decarboxylase,...	Mouse	Baculovirus Insect Cells
	Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the anti...
TMPK-01103	LILRA3/CD85e Protein, Human, Recombinant (His & Avi) HM43,LIR-4HM43e3,HM31,ILT-6,LIR4,CD85e,LILRA3,ILT6	Human	HEK293 Cells
	Human LILRA3, also known as Leukocyte Ig-like receptor 4 (LIR-4), CD85 antigen-like family member E, Immunogobulin-like transcript 6 (ILT-6) and monocyte inhibitory receptor HM43/HM31, is a 70 kD Ig superfamily member that belongs to the leukocyte receptor complex/cluster. Mature LILRA3 is 416 amino acids (aa) in length and contains four C2-type Ig-like domains. Unlike other LILR family members, LILRA3 is actively secreted.LILRA3 acts as soluble receptor for class I MHC antigens. LILRA3 binds b...
TMPJ-01187	Siglec-E Protein, Mouse, Recombinant (hFc) SiglecE,Siglec-E	Mouse	HEK293 Cells
	Siglecs are sialic acid specific I‑type lectins that are characterized by an extracellular domain (ECD) with an N‑terminal Ig‑like V‑set domain followed by varying numbers of Ig‑like C2‑set domains. Mouse Siglec‑E, also known as Myeloid Inhibitory Siglec (MIS), is an 80 ‑ 85 kDa member of the CD33‑related subfamily of Siglecs. Rodent and primate Siglec gene families have significantly diverged, and Siglec‑9 is the most likely human ortholog of mouse Siglec‑E. Siglec‑E is expressed as a heavily N...

重组蛋白

TLR4 Protein, Human, Recombinant (His)

Cat.No: TMPY-02904

Species: Human

Expression System: Baculovirus Insect Cells

CCL24 Protein, Mouse, Recombinant

Cat.No: TMPJ-01341

Species: Mouse

Expression System: E. coli

SP-D Protein, Human, Recombinant (His)

Cat.No: TMPJ-00527

Species: Human

Expression System: HEK293 Cells

ACOD1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02585

Species: Mouse

Expression System: Baculovirus Insect Cells

LILRA3/CD85e Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01103

Species: Human

Expression System: HEK293 Cells

Siglec-E Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01187

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T71285	Metaxalone-d6
	Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone ...
T71212	Lornoxicam-d4
	Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e...
T71288	Phenylbutazone-d9
	Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide). It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-in...
T36408	Rhein-13C4 Rhein-13C4
	Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i...
TMID-0254	Linalool-d3
	Linalool-d3 是 Linalool 的氘代化合物。Linalool 的 CAS 号为 78-70-6。Linalool 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。

同位素标记化合物

Cat.No: T71285

Cat.No: T71212

Phenylbutazone-d9

Cat.No: T71288

Cat.No: T36408

Synonym: Rhein-13C4

Cat.No: TMID-0254

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