Powder: -20°C for 3 years | In solvent: -80°C for 1 year
δ-secretase inhibitor 11是一种分泌酶抑制剂,可用作 阿尔茨海默病(AD) 治疗转化开发的先导化合物。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 298 | 现货 | ||
10 mg | ¥ 446 | 现货 | ||
25 mg | ¥ 948 | 现货 | ||
50 mg | ¥ 1,680 | 现货 | ||
100 mg | ¥ 2,530 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 297 | 现货 |
产品描述 | δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment. |
体外活性 | The inhibitory effect of δ-secretase inhibitor 11 on AEP activity in vitro was tested and the dose-response relationship revealed that the δ-secretase inhibitor 11 had an IC50 value of 0.15 ± 0.09 μM [1]. |
体内活性 | It was found that oral administration of δ-secretase inhibitor 11 (10 mg/kg) significantly suppressed brain AEP activity compared to the vehicle treatment. The concentrations of Aβ1–40 and Aβ1–42 in brain lysates of SAMP8 mice were significantly reduced due to AEP inhibition by δ-secretase inhibitor 11. [1] |
分子量 | 220.23 |
分子式 | C10H12N4O2 |
CAS No. | 842964-18-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.2 mg/mL (10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.5407 mL | 22.7035 mL | 45.4071 mL | 113.5177 mL |
5 mM | 0.9081 mL | 4.5407 mL | 9.0814 mL | 22.7035 mL | |
10 mM | 0.4541 mL | 2.2704 mL | 4.5407 mL | 11.3518 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
δ-secretase inhibitor 11 842964-18-5 Apoptosis Neuroscience Proteases/Proteasome Caspase Beta Amyloid δ-Secretase inhibitor 11 CNS diseases Alzheimer's disease δ secretase inhibitor 11 β-amyloid peptide oxygen-glucose deprivation amyloid precursor protein Abeta asparagine endopeptidase Inhibitor APP AEP Amyloid-β delta-secretase inhibitor 11 Pala cells δsecretase inhibitor 11 inhibit inhibitor