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SI-2是类固醇受体辅激活因子-3(SRC-3或 AIB1)的抑制剂(SMI)。SI-2可选择性降低细胞中 SRC-3的转录活性和蛋白浓度,并选择性诱导低纳摩尔范围(3-20 nM)内的乳腺癌症细胞死亡,但不影响正常细胞存活率。
SI-2是类固醇受体辅激活因子-3(SRC-3或 AIB1)的抑制剂(SMI)。SI-2可选择性降低细胞中 SRC-3的转录活性和蛋白浓度,并选择性诱导低纳摩尔范围(3-20 nM)内的乳腺癌症细胞死亡,但不影响正常细胞存活率。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 2,960 | 现货 | |
5 mg | ¥ 6,860 | 现货 | |
10 mg | ¥ 9,430 | 现货 | |
25 mg | ¥ 13,800 | 现货 | |
50 mg | ¥ 18,900 | 现货 | |
100 mg | ¥ 25,500 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 5,880 | 现货 |
产品描述 | SI-2 is an inhibitor (SMI) of steroid receptor coactivator-3 (SRC-3 or AIB1). SI-2 can selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells, and selectively induce breast cancer cell death with IC50 values in the low nanomolar range (3-20 nM), but not affect normal cell viability. |
别名 | SI2, EPH-116, EPH116, EPH 116 |
分子量 | 265.31 |
分子式 | C15H15N5 |
CAS No. | 223788-33-8 |
Smiles | CN1C=2C(N=C1NN=C(C)C3=CC=CC=N3)=CC=CC2 |
密度 | 1.22 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (207.3 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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