Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-(3-Methoxybenzyl)(9Z,12Z,15Z)-octadeca-9,12,15-trienamide is a natural product
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
20 mg | ¥ 3,850 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,550 | 5日内发货 |
产品描述 | N-(3-Methoxybenzyl)(9Z,12Z,15Z)-octadeca-9,12,15-trienamide is a natural product |
体外活性 | Herein, the isolation of seven NAAs and the assessment of their effects on major protein targets in the ECS network are reported. Four NAAs, octadeca-2E,4E,8E,10Z,14Z-pentaene-12-ynoic acid isobutylamide (1), octadeca-2E,4E,8E,10Z,14Z-pentaene-12-ynoic acid 2'-methylbutylamide (2), hexadeca-2E,4E,9Z-triene-12,14-diynoic acid isobutylamide (3), and hexadeca-2E,4E,9,12-tetraenoic acid 2'-methylbutylamide (4), were identified from Heliopsis helianthoides var. scabra. Compounds 2-4 are new natural products, while 1 was isolated for the first time from this species. The previously described macamides, N-(3-methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (N-(3-Methoxybenzyl)(9Z,12Z,15Z)-octadeca-9,12,15-trienamide, 5), N-benzyl-(9Z,12Z,15Z)-octadecatrienamide (6), and N-benzyl-(9Z,12Z)-octadecadienamide (7), were isolated from Lepidium meyenii (Maca). N-Methylbutylamide 4 and N-benzylamide 7 showed submicromolar and selective binding affinities for the cannabinoid CB1 receptor (Ki values of 0.31 and 0.48 μM, respectively). Notably, compound 7 also exhibited weak fatty acid amide hydrolase (FAAH) inhibition (IC50 = 4 μM) and a potent inhibition of anandamide cellular uptake (IC50 = 0.67 μM) that was stronger than the inhibition obtained with the controls OMDM-2 and UCM707. The pronounced ECS polypharmacology of compound 7 highlights the potential involvement of the arachidonoyl-mimicking 9Z,12Z double-bond system in the linoleoyl group for the overall cannabimimetic action of NAAs. |
别名 | N-间氧基苄基-9顺-12顺-15顺-亚麻酸酰胺(玛卡酰胺 5), 玛卡酰胺 5 |
分子量 | 397.603 |
分子式 | C26H39NO2 |
CAS No. | 383715-23-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
N-(3-Methoxybenzyl)(9Z,12Z,15Z)-octadeca-9,12,15-trienamide 383715-23-9 Others N-(3-Methoxybenzyl)octadeca-9,12,15-trienamide N(3Methoxybenzyl)(9Z,12Z,15Z)octadeca9,12,15trienamide N-间氧基苄基-9顺-12顺-15顺-亚麻酸酰胺(玛卡酰胺 5) 玛卡酰胺 5 N (3 Methoxybenzyl)(9Z,12Z,15Z) octadeca 9,12,15 trienamide Inhibitor inhibitor inhibit