Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MK2-IN-1 hydrochloride (MK 25) 是一种高效的选择性 MAPKAPK2(MK2)激酶抑制剂,其 IC50值为0.11uM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 213 | 现货 | ||
2 mg | ¥ 298 | 现货 | ||
5 mg | ¥ 483 | 现货 | ||
10 mg | ¥ 818 | 现货 | ||
25 mg | ¥ 1,520 | 现货 | ||
50 mg | ¥ 2,430 | 现货 | ||
100 mg | ¥ 3,430 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 542 | 现货 |
产品描述 | MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM) [1]. |
靶点活性 | MK2:0.11 Μm |
体外活性 | MK2-IN-1 has been shown to inhibit pro-inflammatory cytokine secretion from the human THP-1 acute monocytic leukemia cell line, causing inhibition of LPS-stimulated TNF-α (IC50: 4.4 μM) and IL-6 (IC50: 5.2 μM) secretion.1 It can also inhibit IL-1β-stimulated matrix-metalloprotease 13 secretion from the SW1353 chondrosarcoma cell line (IC50: 5.7 μM) and human primary chondrocyte cultures (IC50: 2.2 μM) [1]. |
别名 | MK2 Inhibitor, MK 25 |
分子量 | 509.43 |
分子式 | C27H26Cl2N4O2 |
CAS No. | 1314118-94-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (98.15 mM)
H2O: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.963 mL | 9.8149 mL | 19.6298 mL | 49.0745 mL |
5 mM | 0.3926 mL | 1.963 mL | 3.926 mL | 9.8149 mL | |
10 mM | 0.1963 mL | 0.9815 mL | 1.963 mL | 4.9074 mL | |
20 mM | 0.0981 mL | 0.4907 mL | 0.9815 mL | 2.4537 mL | |
50 mM | 0.0393 mL | 0.1963 mL | 0.3926 mL | 0.9815 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MK2-IN-1 hydrochloride 1314118-94-9 MAPK MK2-IN-1 Hydrochloride MK2 Inhibitor inhibit MK25 MAP kinase activated protein kinase 2 MAPK activated protein kinase 2 MK 25 MAPKAPK2 (MK2) Inhibitor MK2IN1 hydrochloride MK2 IN 1 hydrochloride MAPKAP kinase 2 MK-25 MK-2-IN-1 hydrochloride Mitogen-activated protein kinase activated protein kinase 2 inhibitor