Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.

Histamine N-methyl transferase:18.6 nM(Ki)

在体内给予小剂量的 Amodiaquine dihydrochloride dihydrate 对狗的胃液分泌具有显著增效作用，能显著增强组胺的效应[3]。Amodiaquine dihydrochloride dihydrate 能够预防由P. acnes诱导和LPS加剧的严重肝损伤，且治疗可增强这类小鼠肝脏内组胺水平的升高而不伴随远端甲基组胺的增高[1]。

Whole-cell competitive binding assays: Whole-cell competitive binding assays are performed in LNCaP/AR(codon-switch) (LNCaP/AR(cs)) (harbors a mixture of exogenous wild-type AR and endogenous mutant AR (T877A)) and cells propagated in Iscove's or RPMI media supplemented with 10% fetal bovine serum, or during the assay with 10% charcoal-stripped, dextran-treated fetal bovine serum (CSS). Cells are pre-incubated with 18F-FDHT, increasing concentrations (1pM to 1 μM) of cold Bicalutamide are added, and the assay is performed to measure specific uptake of 18F-FDHT (4). IC50 values are determined using a one site binding model with least squares curve fitting and R2 > 0.99.