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17-phenyl trinor Prostaglandin F2α diethyl amide

17-phenyl trinor Prostaglandin F2α diethyl amide

产品编号 T84653   CAS 1176637-26-5
别名: Bimatoprost diethyl amide

17-Phenyl trinor Prostaglandin F2αdiethyl amide (17-phenyl trinor PGF2αdiethyl amide) is a Prostaglandin F2α(PGF2α) analog characterized by the substitution of the C-1 carboxyl group with an N-diethyl amide. Prostaglandin (PG) esters and N-ethyl amides have demonstrated ocular hypotensive properties, with N-ethyl amides introduced as alternative options for PG hypotensive prodrugs. Studies indicate that both bovine and human corneal tissues can convert N-ethyl amides of various PGs into their free acid forms at a rate of approximately 2.5 µg/g corneal tissue/hr. However, dialkyl amides like 17-phenyl trinor PGF2αdiethyl amide resist conversion by corneal amidase, showing no detectable transformation into free acids. This characteristic suggests their potential as valuable investigative tools for assessing the intrinsic intraocular hypotensive activities of PG amides.

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17-phenyl trinor Prostaglandin F2α diethyl amide Chemical Structure
17-phenyl trinor Prostaglandin F2α diethyl amide, CAS 1176637-26-5
规格 价格/CNY 货期 数量
10 mg 待询 待询
50 mg 待询 待询
618惊喜特惠 4重福利大放送
药物设计专题培训
千万补贴 助力科研
产品目录号及名称: 17-phenyl trinor Prostaglandin F2α diethyl amide (T84653)
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产品描述 17-Phenyl trinor Prostaglandin F2αdiethyl amide (17-phenyl trinor PGF2αdiethyl amide) is a Prostaglandin F2α(PGF2α) analog characterized by the substitution of the C-1 carboxyl group with an N-diethyl amide. Prostaglandin (PG) esters and N-ethyl amides have demonstrated ocular hypotensive properties, with N-ethyl amides introduced as alternative options for PG hypotensive prodrugs. Studies indicate that both bovine and human corneal tissues can convert N-ethyl amides of various PGs into their free acid forms at a rate of approximately 2.5 µg/g corneal tissue/hr. However, dialkyl amides like 17-phenyl trinor PGF2αdiethyl amide resist conversion by corneal amidase, showing no detectable transformation into free acids. This characteristic suggests their potential as valuable investigative tools for assessing the intrinsic intraocular hypotensive activities of PG amides.
别名 Bimatoprost diethyl amide
分子量 443.6
分子式 C27H41NO4
CAS No. 1176637-26-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

17-phenyl trinor Prostaglandin F2α diethyl amide 1176637-26-5 Others Bimatoprost diethyl amide Inhibitor inhibitor inhibit

 

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