Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(S)-Coriolic acid (13(S)-HODE) 是一种重要的细胞内信号剂,是亚油酸与植物和哺乳动物脂氧合酶反应生成的,在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 在 1 μM 左右时,它能抑制肿瘤细胞与血管内皮的粘附,能下调 IRGpIIb/IIIa 受体的表达。(S)-Coriolic acid 是15-脂氧合酶 (15-LOX) 代谢产物,常作为内源性配体激活 PPARγ。(S)-Coriolic acid 诱导线粒体功能障碍 和气道上皮损伤。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 ug (337.33 μM * 1 mL in Ethanol) | ¥ 3,890 | 现货 | ||
250 ug (337.33 μM * 2.5 mL in Ethanol) | ¥ 7,800 | 5日内发货 | ||
500 ug (337.33 μM * 5 mL in Ethanol) | ¥ 14,500 | 5日内发货 |
产品描述 | (S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid inhibits the adhesion of tumor cells to the vascular endothelium and down-regulates the expression of IRGpIIb/IIIa receptors at around 1 μM. (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX), which often acts as an endogenous ligand to activate PPARγ. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial damage. |
体外活性 | (S)-Coriolic acid (30 nM; 6 h; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB.[3] |
体内活性 | (S)-Coriolic acid (0-0.6 mg; Intranasal; once a day for 3 consecutive days; mouse) induces pronounced airway dysfunction, airway neutrophilia, mitochondrial dysfunction, and epithelial injury.[2] |
别名 | 13(S)-HODE |
分子量 | 296.44 |
分子式 | C18H32O3 |
CAS No. | 29623-28-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: >50 mg/mL (per Rao Maddipati)
DMSO: 55 mg/mL (185.54 mM)
PBS (pH 7.2): 1 mg/mL
DMF: >50 mg/mL (per Rao Maddipati)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.3734 mL | 16.8668 mL | 33.7336 mL | 84.3341 mL |
5 mM | 0.6747 mL | 3.3734 mL | 6.7467 mL | 16.8668 mL | |
10 mM | 0.3373 mL | 1.6867 mL | 3.3734 mL | 8.4334 mL | |
20 mM | 0.1687 mL | 0.8433 mL | 1.6867 mL | 4.2167 mL | |
50 mM | 0.0675 mL | 0.3373 mL | 0.6747 mL | 1.6867 mL | |
100 mM | 0.0337 mL | 0.1687 mL | 0.3373 mL | 0.8433 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(S)-Coriolic acid 29623-28-7 DNA Damage/DNA Repair Metabolism Lipoxygenase Mitochondrial Metabolism PPAR 13HODE Coriolic acid 13(S)-HODE Inhibitor inhibitor inhibit