Powder: -20°C for 3 years | In solvent: -80°C for 1 year
δ-Tocotrienol (Delta-Tocotrienol) 是一种维生素 E,存在于蔬菜,水果,种子,坚果,谷物和油等。维生素 E 是抗氧化剂、神经保护剂和抗癌剂,可以降低胆固醇和其他脂质,保护心血管疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 531 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 1,970 | 现货 | ||
25 mg | ¥ 3,930 | 现货 | ||
50 mg | ¥ 5,630 | 现货 | ||
100 mg | ¥ 7,860 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,370 | 现货 |
产品描述 | δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSC-LC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. |
体外活性 | δ-Tocotrienol induced apoptosis and cell cycle arrest at G0/G1 and M phases in nasopharyngeal carcinoma cells. After CNE1 cells were treated with δ-Tocotrienol, 169 genes were up-regulated and 167 down-regulated. ERK1/2 was shown to play a vital role in cell cycle arrest by gene chips. δ-Tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. CNE1 apoptosis was related to dysregulated expression of Bax-2 and Bcl-2. Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of δ-Tocotrienol[1]. |
别名 | Delta-Tocotrienol, δ-生育三烯酚 |
分子量 | 396.61 |
分子式 | C27H40O2 |
CAS No. | 25612-59-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (252.14 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5214 mL | 12.6068 mL | 25.2137 mL | 63.0342 mL |
5 mM | 0.5043 mL | 2.5214 mL | 5.0427 mL | 12.6068 mL | |
10 mM | 0.2521 mL | 1.2607 mL | 2.5214 mL | 6.3034 mL | |
20 mM | 0.1261 mL | 0.6303 mL | 1.2607 mL | 3.1517 mL | |
50 mM | 0.0504 mL | 0.2521 mL | 0.5043 mL | 1.2607 mL | |
100 mM | 0.0252 mL | 0.1261 mL | 0.2521 mL | 0.6303 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
δ-Tocotrienol 25612-59-3 Angiogenesis Apoptosis Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors VEGFR BCL ERK Akt PI3K PDK p53 inhibit δ Tocotrienol Inhibitor δTocotrienol Δ-Tocotrienol Delta-Tocotrienol δ-生育三烯酚 inhibitor